The ENT (equilibrative nucleoside transporter) family is a group of transmembrane proteins responsible for the transport of nucleosides into and out of cells. The main members include ENT1, ENT2, ENT3, and ENT4. They are composed of multiple transmembrane domains and are primarily located on the cell membrane and intracellular membrane systems. The ENT family is involved in regulating cellular nucleoside metabolism, energy supply, and signal transduction, influencing cell growth and death by promoting the uptake and release of nucleosides. The expression of the ENT family is tissue- and cell-specific, and mutations or dysregulation of their genes are associated with various diseases, including cardiovascular diseases, neurodegenerative diseases, and cancer.