N-Heterocyclic carbenes (NHCs) is a cyclic carbene species with two neighboring nitrogen atoms, they have attracted increasing attention in chemistry because of their strong δ-donor capacity that makes them very useful ligands for various transition metals. Moreover, the easy introduction of chiral elements into NHCs and the facile preparation of their precursors have made chiral NHCs promising chiral ligands in metal-based asymmetric catalysis. Therefore, strategies for the design of efficient NHC–metal catalysts and novel asymmetric synthetic methodologies have dramatically increased over the past 10 years. Herein, we introduce a series of chiral NHCs for copper. Ambeed is aimed to accelerate cutting-edge research projects in NHC ligand mediated chemistry.

Tech Notes:

[1] An efficient, practical and selective multicomponent NHC-Cu-catalysed process for sequential Cu-B(pin) addition

[2] Catalytic enantioselective 1,6-conjugate additions of propargyl and allyl groups

[3] N-Heterocyclic Carbene−Cu-catalyzed enantioselective allenyl conjugate addition

[4] NHC-copper-catalyzed asymmetric dearomative silylation of indoles

References: [1] Nature, 2014, 513, 367. [2] Nature, 2016, 537, 387. [3] Org. Lett. 2018, 20, 6896. [4] J. Org. Chem. 2018, 83, 14758.