The carboxypeptidase family encompasses a variety of enzymes responsible for cleaving amino acids from the C-terminus of peptide chains. These enzymes are distributed both intracellularly and extracellularly, with carboxypeptidase A and B primarily found in the pancreas, where they participate in protein digestion. They play crucial roles in protein processing, blood pressure regulation, and the coagulation mechanism. Family members are classified based on the different metal ions present in their active sites, such as zinc and cobalt. Gene expression varies in tissue specificity and developmental stages, and mutations may lead to metabolic abnormalities or diseases, such as hereditary pancreatitis or coagulation disorders.