Home PROTAC Molecule BTK/PROTAC
Proteolysis-targeting chimeras (PROTACs) targeting Bruton's tyrosine kinase (BTK), known as BTK-PROTACs, have emerged as a promising strategy to overcome the limitations associated with BTK inhibitors. Nevertheless, the rational discovery of orally bioavailable BTK-PROTACs poses notable challenges. In this study, dimensionality reduction analysis and the validation of model molecules were employed to identify crucial structural features aimed at enhancing the oral absorption of BTK-PROTACs.
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