Home Chemistry Organic Building Blocks Fluorinated Building Blocks 2-(3-Fluorophenyl)Acetic Acid
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—CH2COOH).
Metalation Reactions: Fluorobenzene can undergo metalation reactions, where a metal species (such as an organolithium or organomagnesium compound) replaces a hydrogen atom on the benzene ring. These metalated intermediates can then be used in various synthetic transformations.
Decarboxylation: Under certain conditions, 2-phenylacetic acid can undergo decarboxylation, which results in the loss of carbon dioxide and formation of a substituted 【benzene compound|https://www.ambeed.com/benzene-compounds.html】. Reaction: 2-Phenylacetic acid → Substituted Benzene Compound + Carbon Dioxide
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2-(2-Bromo-3,4-difluorophenyl)acetic acid
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2-(2,4-Dichloro-5-fluorophenyl)acetic acid
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3-Fluoro-5-(trifluoromethyl)phenylacetic Acid
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2-(2-Bromo-3,6-difluorophenyl)acetic acid
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2-(4,5-Difluoro-2-nitrophenyl)acetic acid
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(6-Amino-2,3-difluorophenyl)acetic acid
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