Home Chemistry Organic Building Blocks Fluorinated Building Blocks 1-Fluoro-2-Methylbenzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—CH3).
Metalation Reactions: Fluorobenzene can undergo metalation reactions, where a metal species (such as an organolithium or organomagnesium compound) replaces a hydrogen atom on the benzene ring. These metalated intermediates can then be used in various synthetic transformations.
Alkylation: Similar to acylation, toluene can also undergo Friedel-Crafts alkylation reactions, where an alkyl group is introduced onto the benzene ring. Alkylation reactions also require a Lewis acid catalyst.
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Methyl 3-fluoro-5-hydroxy-4-methylbenzoate
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3-(4-Fluoro-3-methylphenyl)propionic acid
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(S)-1-(3-Fluoro-4-methylphenyl)ethanamine
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