Home Chemistry Organic Building Blocks Aliphatic Cyclic Hydrocarbons (Cyclopropylmethoxy)Benzene
Electrophilic Aromatic Substitution: (Cyclopropylmethoxy)benzene is an aromatic compound due to the benzene ring. It can undergo electrophilic aromatic substitution reactions with electrophiles (electron-deficient species). Common examples include nitration, sulfonation, and Friedel-Crafts reactions.
Halogenation: The benzene ring can be halogenated using halogenating agents like chlorine or bromine in the presence of a Lewis acid catalyst. For example, you can replace a hydrogen atom on the benzene ring with a halogen atom.
Alkylation and Acylation: (Cyclopropylmethoxy)benzene can be alkylated or acylated using alkyl halides or acyl halides in the presence of a Lewis acid catalyst. This leads to the introduction of alkyl or acyl groups onto the benzene ring.
rignard Reactions: You can perform Grignard reactions with (cyclopropylmethoxy)benzene to introduce various organic groups onto the benzene ring.
Hydrolysis: The cyclopropylmethoxy group can be hydrolyzed under acidic or basic conditions to yield cyclopropylmethanol and benzoic acid or its derivatives.
Esterification: (Cyclopropylmethoxy)benzene can react with carboxylic acids and acid chlorides to form esters. This reaction is often catalyzed by acid or base.
Friedel-Crafts Acylation: (Cyclopropylmethoxy)benzene can undergo Friedel-Crafts acylation reactions, where an acyl group is introduced onto the benzene ring in the presence of a Lewis acid catalyst.
Substitution Reactions: Depending on the reaction conditions, the cyclopropylmethoxy group can be substituted by other nucleophiles, leading to the formation of various derivatives.
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(4-(Cyclopropylmethoxy)phenyl)boronic acid
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3-Chloro-4-(cyclopropylmethoxy)phenylboronic acid
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(4-(Cyclopropylmethoxy)-2,6-difluorophenyl)boronic acid
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3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde
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4-(Cyclopropylmethoxy)-3-fluorobenzoic acid
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3-(Cyclopropylmethoxy)-4-hydroxybenzoic acid
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5-Bromo-2-(cyclopropylmethoxy)benzonitrile
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1-Bromo-3-(cyclopropylmethoxy)-5-(trifluoromethyl)benzene
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(3-Bromo-5-(cyclopropylmethoxy)phenyl)boronic acid
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