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Chemical Structure| 90952-27-5 Chemical Structure| 90952-27-5
Chemical Structure| 90952-27-5

Thiol-PEG4-alcohol

CAS No.: 90952-27-5

Thiol-PEG4-alcohol is a PEG-based PROTAC linker employed in the synthesis of PROTAC molecules.

4.5 *For Research Use Only !

Cat. No.: A753029 Purity: 97%

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Product Details of Thiol-PEG4-alcohol

CAS No. :90952-27-5
Formula : C8H18O4S
M.W : 210.29
SMILES Code : OCCOCCOCCOCCS
MDL No. :MFCD22574773
InChI Key :GKKYNULPAQDGHI-UHFFFAOYSA-N
Pubchem ID :10465720

Safety of Thiol-PEG4-alcohol

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H314
Precautionary Statements:P260-P264-P270-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P321-P363-P405-P501
Class:8(6.1)
UN#:2922
Packing Group:

Application In Synthesis of Thiol-PEG4-alcohol

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 90952-27-5 ]

[ 90952-27-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 69655-76-1 ]
  • [ 90952-27-5 ]
  • C80H168O44S8Si8 [ No CAS ]
YieldReaction ConditionsOperation in experiment
89% With DPAP; In tetrahydrofuran; N,N-dimethyl-formamide; for 1h;Photolysis; Inert atmosphere; Commercial POSS-octavinyl 10 (100 mg, 0.16 mmol, 1 eq) was placed in DMF/THF (2/1 3 mL) with l-mercapto-11 -hydroxy-3,6,9-trioxaundecane (500 mg, 2.4 mmol, 15 eq) and DPAP (20 mg, 0.008 mmol, 0.5 eq). The reaction was photo-activated (365 nm) and stirred for 1 hour. The crude product was purified by Sephadex LH-20 to yield compound 37 (327 mg, 89percent). 1H NMR (MeOD4, 300MHz) d: 3.70-3.61 (96H, m, CH20), 3.61-3.55 (16H, m, H-4), 2.80- 2.65 (32H, m, H-2, H-3), 1.15-1.00 (16H, t, J1- 2 = 8.0 Hz, H-l); 13C NMR (MeOD4, 75MHz) d: 73.7, 72.1, 71.7, 71.6, 71.5, 71.3 (6 CH20), 62.3 (C-4), 32.3 (C-3), 27.4 (C-2), 14.0 (C-l). HRMS (ES-) m/z calcd for C80H167O44SisS8 [M-H]'calc : 2311.6750, found 2311.6707.
 

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