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Chemical Structure| 575474-01-0 Chemical Structure| 575474-01-0

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Chemical Structure| 575474-01-0

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Product Details of [ 575474-01-0 ]

CAS No. :575474-01-0
Formula : C8H10N2O
M.W : 150.18
SMILES Code : NC1=CC=C2C(OCCN2)=C1
MDL No. :MFCD09029649

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 575474-01-0 ]

[ 575474-01-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 26215-14-5 ]
  • [ 575474-01-0 ]
YieldReaction ConditionsOperation in experiment
4% With lithium aluminium tetrahydride; In tetrahydrofuran; at 70℃; for 3h; To asolution of 7-amino-4H-1,4-benzoxazin-3-one (300 mg, 1.83mmol) in THF (10 mL) was added LiA1H4 (2.0 M in THF, 4.6 mL,9.15 mmol), and the mixture stirred at 70 C for 3 h. The reaction was cooled to room temperature, H20 (50 mL) added and the product extracted with EtOAc (50 mL) . The organic phase was separated, washed with brine (50 mL), dried over anhydrous Na2504, filtered and the solvent evaporated underreduced pressure. The resultant residue was purified by silica gel flash-column chromatography, with DCM/EtOAc (6:4)as the eluent, to yield the title compound as a dark oil(120 mg, 44%) : ‘H NNR (400 MHz, DMSO-d6) 6 6.30 (d, J = 8.9Hz, 1H) , 6.03-5.94 (m, 2H) , 4.07-3.98 (m, 2H) , 3.21-3.07 (m, 2H) ; UPLC-MS: tR = 1.24 mm (polar method) ; MS (ESI)m/z calcd for C8H,,N20 (M+H): 151.1, found: 151.1.
 

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