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Structure of 214055-12-6

Chemical Structure| 214055-12-6

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Product Details of [ 214055-12-6 ]

CAS No. :214055-12-6
Formula : C6H5ClFNO
M.W : 161.56
SMILES Code : OCC1=NC=C(Cl)C=C1F
MDL No. :MFCD16607027
InChI Key :YAQXGUYPYJOOJC-UHFFFAOYSA-N
Pubchem ID :67981595

Safety of [ 214055-12-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 214055-12-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 214055-12-6 ]

[ 214055-12-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 207994-08-9 ]
  • [ 214055-12-6 ]
YieldReaction ConditionsOperation in experiment
1.88 g (1) To a suspension of the Compound 1 (5.21 g) in 1,2- dimethoxyethane (30 mE) were added isobutyl chloroformate (4.24 mE) and N-methylmorpholine (3.6 mE) under ice-cooling, and the resulting mixture was stirred at the same temperature for 1 hout The resulting insoluble matters were removed by filtration, and to the resulting filtrate was added an aqueous solution of sodium borohydride (sodium borohydride (1.69 g)+water (15 mE)) under ice-cooling, and the resulting mixture was stirred at room temperature for 2 hours. To the reaction mixture were added water and chloroform, and the resulting mixture was stirred, and then extracted with chloroform. The resulting organic layers were dried, and then concentrated under reduced pressure. The resulting residues were purified by NH silica gel column chromatography (hexane:ethyl acetate=95:5 to 65:35) to give the Compound 2 (1.88 g) as a colorless solid. MS (APCI): mlz 162/164 [M+H]
1.88 g With 4-methyl-morpholine; isobutyl chloroformate; In 1,2-dimethoxyethane; for 1h;Cooling with ice; (1) Compound 1 (5.21 g)Of 1, 2-dimethoxyethane (30 mL)Isobutyl chloroformate (4.24 mL) was added to the suspension under ice cooling,And N-methylmorpholine(3.6 mL)Is added,The mixture was stirred at the same temperature for 1 hour.Insolubles were removed by filtration,To the filtrate was added sodium borohydride aqueous solution(Sodium borohydride 1.69 g + water 15 mL)Is added,And the mixture was stirred at room temperature for 2 hours.Water and chloroform were added to the reaction mixture, followed by stirring,And extracted with chloroform.The obtained organic layer was dried and concentrated under reduced pressure.The residue was purified by NH silica gel column chromatography (hexane: ethyl acetatePurity: 95: 5 to 65: 35)Compound 2 (1.88 g) was obtained as a colorless solid.
 

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