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[ CAS No. 1227599-41-8 ] {[proInfo.proName]}

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Chemical Structure| 1227599-41-8
Chemical Structure| 1227599-41-8
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Product Details of [ 1227599-41-8 ]

CAS No. :1227599-41-8 MDL No. :MFCD16609960
Formula : C6H5BrFNO Boiling Point : -
Linear Structure Formula :- InChI Key :NYMSNXYJKHEMCQ-UHFFFAOYSA-N
M.W : 206.01 Pubchem ID :72212857
Synonyms :

Safety of [ 1227599-41-8 ]

Signal Word:Warning Class:
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 UN#:
Hazard Statements:H315-H319 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1227599-41-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1227599-41-8 ]

[ 1227599-41-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 2440199-64-2 ]
  • [ 1227599-41-8 ]
  • [ 2440199-38-0 ]
YieldReaction ConditionsOperation in experiment
13% With tris-(dibenzylideneacetone)dipalladium(0); lithium tert-butoxide; XPhos In 1,4-dioxane at 80℃; for 2h; Inert atmosphere; Intermediate 48 4-benzyl 1-(tert-butyl) (Z)-2-((3-fluoro-2-methoxypyridin-4-yl)methylene)piperazine-1,4- dicarboxylate: To a solution of 4-benzyl 1-(tert-butyl) (Z)-2-((2- tosylhydrazineylidene)methyl)piperazine-1,4-dicarboxylate (1.0 g, 1.94 mmol) and 4-bromo- 3-fluoro-2-methoxypyridine (0.599 g, 2.91 mmol) in dioxane (10.0 mL) were added Pd2(dba)3 (0.177 g, 0.194 mmol), XPhos (0.092 g, 0.194 mmol) and lithium 2-methylpropan- 2-olate (0.465 g, 5.82 mmol). The mixture was stirred at 80 °C for 2 hours under N2. The reaction was concentrated and was purified by column chromatography (Petroleum ether/EtOAc = 5/1) on silica gel to provide the title compound (118 mg, 13% yield). LCMS (ESI): [M+H] 458.
  • 2
  • [ 2440199-64-2 ]
  • [ 1227599-41-8 ]
  • [ 2440199-39-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: lithium tert-butoxide; tris-(dibenzylideneacetone)dipalladium(0); XPhos / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere 2: hydrogen; 10 wt% Pd(OH)2 on carbon / methanol / 2 h / 30 °C / 2068.65 Torr
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Technical Information

• Acetal Formation • Acid-Catalyzed α -Halogenation of Ketones • Addition of a Hydrogen Halide to an Internal Alkyne • Alcohols from Haloalkanes by Acetate Substitution-Hydrolysis • Alcohols React with PX3 • Alkyl Halide Occurrence • Alkylation of an Alkynyl Anion • An Alkane are Prepared from an Haloalkane • Chichibabin Reaction • Convert Haloalkanes into Alcohols by SN2 • Esters Are Reduced by LiAlH4 to Give Alcohols • Esters Hydrolyze to Carboxylic Acids and Alcohols • Ether Synthesis by Oxymercuration-Demercuration • Ethers Synthesis from Alcohols with Strong Acids • Friedel-Crafts Alkylation of Benzene with Haloalkanes • General Reactivity • Grignard Reaction • Grignard Reagents Transform Esters into Alcohols • Halogenation of Alkenes • Hantzsch Pyridine Synthesis • Hiyama Cross-Coupling Reaction • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Methylation of Ammonia • Methylation of Ammonia • Nomenclature of Ethers • Preparation of Amines • Preparation of Ethers • Primary Ether Cleavage with Strong Nucleophilic Acids • Pyridines React with Grignard or Organolithium Reagents • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Dihalides • Reactions of Ethers • Ring Opening of Oxacyclopropane • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Synthesis of Alcohols from Tertiary Ethers • The Nucleophilic Opening of Oxacyclopropanes • Williamson Ether Syntheses
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