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Chemical Structure| 1750-42-1 Chemical Structure| 1750-42-1
Chemical Structure| 1750-42-1

Isoxazol-3-amine

CAS No.: 1750-42-1

Synonyms: 3-Aminoisoxazole

4.5 *For Research Use Only !

Cat. No.: A206388 Purity: 98%

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Product Details of [ 1750-42-1 ]

CAS No. :1750-42-1
Formula : C3H4N2O
M.W : 84.08
SMILES Code : NC1=NOC=C1
Synonyms :
3-Aminoisoxazole
MDL No. :MFCD00038814

Safety of [ 1750-42-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis [ 1750-42-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1750-42-1 ]

[ 1750-42-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1750-42-1 ]
  • [ 6627-22-1 ]
  • [ 1097250-90-2 ]
YieldReaction ConditionsOperation in experiment
40% With sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;tris-(dibenzylideneacetone)dipalladium(0); In water; toluene; at 100℃; for 3h; To compound 12.1 (0.16 g, 0.91 mmol, 1.0 equiv), isoxazol-3-ylamine (92 mg, 1.1 mmol, 1.2 equiv), tris(dibenzylideneacetone)-dipalladium (21 mg, 0.023 mmol, 0.025 equiv), xantphos (39 mg, 0.068 mmol, 0.075 equiv), and Na2CO3 (133 mg, 1.4 mmol, 1.4 equiv) in toluene (3 mL) was added H2O (16 μL, 0.91 mmol, 1.0 equiv). The reaction mixture was heated to 100 C. and stirred for 3 hr, whereupon it was cooled to RT. The mixture was filtered through Celite and adsorbed onto SiO2 gel. Purification by flash column chromatography (50-75-100% EtOAc/hexanes) afforded 12.2 (0.79 mg, 40%). LCMS: m/z: 221 [M+1]+.
  • 2
  • [ 1750-42-1 ]
  • [ 2012-74-0 ]
  • [ 1208552-75-3 ]
 

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