Home Cart Sign in  
Product Citations

Alternative Products

Product Details of [ 459418-63-4 ]

CAS No. :459418-63-4
Formula : C14H9BrFN3
M.W : 318.15
SMILES Code : FC1=CC=C(NC2=C3C=C(Br)C=CC3=NC=N2)C=C1
MDL No. :MFCD02968279

Safety of [ 459418-63-4 ]

Application In Synthesis [ 459418-63-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 459418-63-4 ]

[ 459418-63-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 459418-63-4 ]
  • [ 1083326-75-3 ]
  • N‐(5‐{4‐[(4‐fluorophenyl)amino]quinazolin‐6‐yl}‐2‐methoxypyridin‐3‐yl)methanesulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
64.3% With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); caesium carbonate; In N,N-dimethyl-formamide; at 90℃; for 4h;Inert atmosphere; General procedure: A solution of the 3a (0.164 g, 0.5 mmol), 5a (0.158 g, 0.5 mmol),Pd(dppf)2Cl2 (0.018 g, 0.025 mmol) and Cs2CO3 (0.33 g, 0.56 mmol)in DMF (10 ml) under an atmosphere of N2 was stirred at 90 C for4 h. DMF was removed under reduced pressure and the residuewaspurified through a column chromatography on silica with chloroform/methanol (V:V 50:1) as a white solid (0.12 g, 68.2% yield)..
 

Historical Records