2111-75-3|4-(Prop-1-en-2-yl)cyclohex-1-enecarbaldehyde| Ambeed

Yield	Reaction Conditions	Operation in experiment
92%	With hydrogen; sodium hydroxide In ethanol at 50℃; for 16 h; Autoclave; Inert atmosphere	Example 13Hydrogenation Reaction of Perillaldehyde (S/C=500)Into a stainless steel autoclave equipped with a glass inner tube, [Cu(NO₃)(PPh₃)₂] (11.7 mg, 0.018 mmol) and DPPB (7.7 mg, 0.018 mmol) were introduced. The inside of the autoclave was then replaced with nitrogen. To the autoclave, an ethanolic solution of sodium hydroxide (0.03 M) (6.0 mL, 0.18 mmol) and perillaldehyde (2.02 mL, 9 mmol) were added, and stirring was performed at a hydrogen pressure of 5 MPa at 50° C. for 16 hours. The hydrogen was released with great care, and the conversion was analyzed by GC (>99percent). The contents were concentrated, and then purified by silica gel chromatography. Thus, 1.26 g of the corresponding alcohol was obtained. obtained.
92%	With hydrogen; sodium hydroxide In ethanol at 50℃; for 16 h; Autoclave; Inert atmosphere	(Example 13) Hydrogenation Reaction of Perillaldehyde (S/C=500) Into a stainless steel autoclave equipped with a glass inner tube, [Cu(NO₃)(PPh₃)₂] (11.7mg, 0.018 mmol) and DPPB (7.7 mg, 0.018 mmol) were introduced. The inside of the autoclave was then replaced with nitrogen. To the autoclave, an ethanolic solution of sodium hydroxide (0.03 M) (6.0 mL, 0.18 mmol) and perillaldehyde (2.02 mL, 9 mmol) were added, and stirring was performed at a hydrogen pressure of 5 MPa at 50°C for 16 hours. The hydrogen was released with great care, and the conversion was analyzed by GC (>99percent). The contents were concentrated, and then purified by silica gel chromatography. Thus, 1.26 g of the corresponding alcohol was obtained. Isolated yield: 92percent, 1d/2d = 52/1
35%	With 1,1'-bis-(diphenylphosphino)ferrocene; silver(I) hexafluorophosphate; tripropylsilane; N-ethyl-N,N-diisopropylamine In water at 100℃; for 24 h;	General procedure: Degassed CH2Cl2 (0.25 mL) was added to a microwave tube containing the ligand dppf (8.3 mg, 0.015 mmol) and AgPF6 (2.5 mg, 0.01 mmol) under argon. The resulting suspension was stirred at r.t., until a clear, colorless solution was obtained; then the solvent was removed under high vacuum. Benzaldehyde (1a; 20.3 μL, 0.2 mmol), tripropylsilane (2a;125 μL, 0.6 mmol), DIPEA (6.9 μL, 0.04 mmol), and H2O(0.5 mL) were subsequently added. The reaction mixture was stirred for 24 h at 100 °C, then cooled to r.t. and extracted with CH2Cl2 (3 × 10 mL). The combined organicphase was concentrated and purified by flash column chromatography on silica gel (hexane–EtOAc, 20:1) to give the desired product 3a as a colorless oil (19.5 mg, 90percent).

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4-(Prop-1-en-2-yl)cyclohex-1-enecarbaldehyde

CAS No.: 2111-75-3

Alternative Products

Product Details of [ 2111-75-3 ]

Safety of [ 2111-75-3 ]

Application In Synthesis [ 2111-75-3 ]

[ 2111-75-3 ] Synthesis Path-Upstream 1~3

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed