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Chemical Structure| 2243882-74-6 Chemical Structure| 2243882-74-6
Chemical Structure| 2243882-74-6

WEE1-IN-5

CAS No.: 2243882-74-6

WEE1-IN-5 is an effective WEE1 inhibitor that can eliminate the G2 checkpoint, increasing cancer cells' sensitivity to DNA-damaging agents, suitable for anti-cancer research.

Synonyms: Debio 0123

4.5 *For Research Use Only !

Cat. No.: A1673072 Purity: 98%

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Product Details of [ WEE1-IN-5 ]

CAS No. :2243882-74-6
Formula : C26H28Cl2N6O
M.W : 511.45
SMILES Code : O=C1C2=CN=C(NC3=CC=C(C4CCN(C)CC4)C(C)=C3)N=C2N(C)CN1C5=C(Cl)C=CC=C5Cl
Synonyms :
Debio 0123
MDL No. :MFCD34603990

Safety of [ WEE1-IN-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of [ WEE1-IN-5 ]

Hedgehog

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT05109975 Advanced Solid Tumors PHASE1 RECRUITING 2025-06-27 South Texas Accelerated Resear... More >>ch Therapeutics (START) Midwest, Grand Rapids, Michigan, 49546, United States|David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center, New York, New York, 10021, United States|South Texas Accelerated Research Therapeutics (START), San Antonio, Texas, 78229, United States|Froedtert Hospital and the Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, United States|Hospital Universitari Vall d'Hebron, Barcelona, 08035, Spain|Institut Catala de Oncologia, Girona, 17007, Spain|Clinica Universidad de Navarra, Madrid, 28027, Spain|START Madrid. Hospital Fundación Jimenez Diaz, Madrid, 28040, Spain|Hospital Universitario 12 de Octubre, Madrid, 28041, Spain|Hospital Universitario La Paz, Madrid, 28046, Spain|Clinica Universidad de Navarra, Pamplona, 31008, Spain|Istituto Oncologico della Svizzera italiana - Ente Ospedaliero Cantonale, Bellinzona, 6500, Switzerland|Inselspital, Universitaetsspital Bern, Freiburgstrasse 4, Bern, 3010, Switzerland|Kantonsspital St. Gallen, Rorschacher Strasse 95, Saint Gallen, 9007, Switzerland|Universit?tsspital Zürich, Dermatologische Klinik, Zürich, 8058, Switzerland Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.96mL

0.39mL

0.20mL

9.78mL

1.96mL

0.98mL

19.55mL

3.91mL

1.96mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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