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Chemical Structure| 52727-62-5 Chemical Structure| 52727-62-5
Chemical Structure| 52727-62-5

Methyl 2-amino-3,5-dichlorobenzoate

CAS No.: 52727-62-5

4.5 *For Research Use Only !

Cat. No.: A972182 Purity: 95%

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Product Details of [ 52727-62-5 ]

CAS No. :52727-62-5
Formula : C8H7Cl2NO2
M.W : 220.05
SMILES Code : O=C(OC)C1=CC(Cl)=CC(Cl)=C1N
MDL No. :MFCD07439809

Safety of [ 52727-62-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis [ 52727-62-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 52727-62-5 ]

[ 52727-62-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3279-95-6 ]
  • [ 52727-62-5 ]
  • [ 929710-54-3 ]
YieldReaction ConditionsOperation in experiment
30% Example 3 3,5-dichloro-2-amino-N-(2-hydroxyethoxy)benzamide 9 g (40.9 mmol) of methyl 3,5-dichloro-2-aminobenzoate and 6.3 g (81.8 mmol) of 2-(aminooxy)ethanol are initially charged in 90 ml of methanol, and 22.1 g (122.7 mmol) of sodium methoxide as a 30% strength solution in methanol are added dropwise at 20 C. The mixture is stirred at 50 C. overnight. The mixture is cooled and poured onto 400 ml of water, and the pH is adjusted to 3 using 1 N hydrochloric acid. The mixture is extracted 3 times with in each case 150 ml of ethyl acetate and the extracts are dried with sodium sulphate and concentrated using a rotary evaporator. Purification by silica gel chromatography cyclohexane/ethyl acetate=3:1, then cyclohexane/ethyl acetate=1:1. Yield: 4 g (30% of theory)
 

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