*Storage: Keep in dark place,Inert atmosphere,2-8°C.
*Shipping:
Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also exhibits activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22, and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain.
Synonyms: BW 759;2'-Nor-2'-deoxyguanosine;2'-Nor-2'-deoxyguanosine, BW 759, Ganciclovir
4.5
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Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also exhibits activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22, and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain.
Synonyms: BW 759;2'-Nor-2'-deoxyguanosine;2'-Nor-2'-deoxyguanosine, BW 759, Ganciclovir
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CAS No. : | 82410-32-0 |
Formula : | C9H13N5O4 |
M.W : | 255.23 |
SMILES Code : | O=C1NC(N)=NC2=C1N=CN2COC(CO)CO |
Synonyms : |
BW 759;2'-Nor-2'-deoxyguanosine;2'-Nor-2'-deoxyguanosine, BW 759, Ganciclovir
|
MDL No. : | MFCD00870588 |
InChI Key : | IRSCQMHQWWYFCW-UHFFFAOYSA-N |
Pubchem ID : | 135398740 |
GHS Pictogram: | ![]() |
Signal Word: | Danger |
Hazard Statements: | H340-H361 |
Precautionary Statements: | P201-P202-P280-P308+P313-P405-P501 |
Num. heavy atoms | 18 |
Num. arom. heavy atoms | 9 |
Fraction Csp3 | 0.44 |
Num. rotatable bonds | 5 |
Num. H-bond acceptors | 6.0 |
Num. H-bond donors | 4.0 |
Molar Refractivity | 61.64 |
TPSA ? Topological Polar Surface Area: Calculated from | 139.28 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from | 0.16 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by | -1.66 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from | -2.11 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from | -1.48 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by | -1.0 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions | -1.22 |
Log S (ESOL):? ESOL: Topological method implemented from | -0.42 |
Solubility | 97.8 mg/ml ; 0.383 mol/l |
Class? Solubility class: Log S scale | Very soluble |
Log S (Ali)? Ali: Topological method implemented from | -0.75 |
Solubility | 45.0 mg/ml ; 0.176 mol/l |
Class? Solubility class: Log S scale | Very soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by | -0.75 |
Solubility | 45.7 mg/ml ; 0.179 mol/l |
Class? Solubility class: Log S scale | Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg | Low |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg | No |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) | No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) | No |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) | No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) | No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) | No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) | No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from | -9.04 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from | 0.0 |
Ghose? Ghose filter: implemented from | None |
Veber? Veber (GSK) filter: implemented from | 0.0 |
Egan? Egan (Pharmacia) filter: implemented from | 1.0 |
Muegge? Muegge (Bayer) filter: implemented from | 0.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat | 0.55 |
PAINS? Pan Assay Interference Structures: implemented from | 0.0 alert |
Brenk? Structural Alert: implemented from | 0.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from | No; 1 violation:MW<0.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) | 2.61 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75.7% | Stage #1: With Trimethyl borate In toluene for 5 h; Reflux; Large scale Stage #2: at 20℃; for 6 h; Large scale Stage #3: at 0 - 20℃; for 2 h; Large scale | 500.0 g (1.96 mol, 1.0 eq) of ganciclovir, 244.4 g (2.35 mol, 1.2 eq) of trimethyl borate,7.5 kg of toluene was added to the reaction vessel, and heated to reflux for 5 hours. The TLC controlled raw material reaction was complete.The temperature was lowered to room temperature, 396.7 g (3.93 mol, 2.0 eq) of triethylamine was added, then 323.7 g (2.94 mol, 1.5 eq) of 1-acetylimidazole was added, and the mixture was stirred at room temperature for 6 hours.The ratio of monoacetyl ganciclovirand N,O-diacetyl ganciclovir in the HPLC was 94/4.The temperature was lowered to 0 to 10 ° C, 2.0 kg of methanol was added dropwise, and the mixture was stirred at room temperature for 2 hours, and the solvent was concentrated under reduced pressure.Add 3.0 kg of ethyl acetate, wash once with 500 g of water, layer, and extract the aqueous layer with 500 g of ethyl acetate.Concentration under reduced pressure, ethanol recrystallization to give colorless crystals 440.9 g, yield 75.7percent, purity 99.2percent, |
75.7% | Stage #1: With Trimethyl borate In toluene for 5 h; Reflux Stage #2: With triethylamine In toluene at 20℃; for 6 h; Stage #3: With methanol In toluene at 0 - 20℃; for 2 h; | 500.0g (1.96mol, 1.0eq) of ganciclovir, 244. 4g of trimethyl borate (2·35mol, 1 · 2eq), 7.5kg of toluene were added to the reaction kettle, heated to reflux for 5 hours, controlled by TLC The reaction of the starting material was completed, and the temperature was lowered to room temperature. Triethylamine 396 · 7 g (3 · 93 mol, 2.0 eq) was added, then 1 - acetylimidazole 323 · 7 g (2 · 94 mol, 1.5 eq) was added, and stirred at room temperature for 6 hours, HPLC The ratio of controlled monoacetyl ganciclovir and N,0-diacetyl ganciclovir was 94/4, the temperature was lowered by 0~10 ° C, 2.0 kg of methanol was added dropwise, and the mixture was stirred at room temperature for 2 hours, and concentrated under reduced pressure. the solvent, ethyl acetate was added 3.0kg, 500g once with water, separated and the aqueous layer was extracted with 500g ethyl acetate, the organic layers were combined and concentrated under reduced pressure, and recrystallized from ethanol to give colorless crystals 440.9g, a yield of 75.7percent, Purity 99.2percent |
75.7% | Stage #1: With Trimethyl borate In toluene for 5 h; Reflux Stage #2: With triethylamine In toluene at 20℃; for 6 h; Stage #3: With methanol In toluene at 0 - 20℃; for 2 h; | 500.0 g (1.96 mol, 1.0 eq) of ganciclovir, 244.4 g (2.35 mol, 1.2 eq) of trimethyl borate,7.5 kg of toluene was added to the reaction kettle.Heated to reflux for 5 hours,The TLC controlled raw material reaction is complete,Down to room temperature,396.7 g (3.93 mol, 2.0 eq) of triethylamine was added, followed by the addition of 1-acetylimidazole 323.7 g (2.94 mol, 1.5 eq).Stir at room temperature for 6 hours.The ratio of monoacetyl ganciclovir and N,O-diacetyl ganciclovir in the HPLC was 94/4, the temperature was lowered by 0-10 °C, 2.0 kg of methanol was added dropwise, and the dropping was completed.Stir at room temperature for 2 hours.The solvent was concentrated under reduced pressure, and 3.0 kg of ethyl acetate was added, washed once with 500 g of water, and layered.The aqueous layer was extracted with EtOAc (EtOAc).Recrystallization of ethanol gave 440.9 g of colorless crystals.The yield is 75.7percent, the purity is 99.2percent, |
75.7% | Stage #1: With Trimethyl borate In toluene for 5 h; Reflux Stage #2: With triethylamine In toluene at 20℃; for 6 h; | 500.0 g (1.96 mol, 1.0 eq) of ganciclovir, 244.4 g (2.35 mol, 1.2 eq) of trimethyl borate, 7.5 kg of toluene were added to the reaction kettle, and heated to reflux for 5 hours.The TLC controlled raw material reacted completely, dropped to room temperature, and added triethylamine.396.7 g (3.93 mol, 2.0 eq), then added 3-acetylimidazole 323.7 g (2.94 mol, 1.5 eq), stirred at room temperature for 6 hours, HPLC controlled monoacetyl ganciclovir and N, O-diacetyl The ratio of Lovi is 94/4, the temperature is lowered to 0-10 ° C, 2.0 kg of methanol is added dropwise, and the mixture is stirred at room temperature for 2 hours. The solvent is concentrated under reduced pressure. 3.0 kg of ethyl acetate is added, and once with 500 g of water, the layers are separated. The aqueous layer was extracted with 500 g of ethyl acetate and the organic layers were combined.Concentration under reduced pressure, ethanol recrystallization to give colorless crystals 440.9 g, yield 75.7percent, purity 99.2percent, |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75.2% | Stage #1: With triethyl borate In 2-methyltetrahydrofuran for 3 h; Reflux; Large scale Stage #2: at 20℃; for 6 h; Large scale Stage #3: at 0 - 20℃; for 3 h; Large scale | 500.0 g (1.96 mol, 1.0 eq) of ganciclovir, 314.7 g (2.15 mol, 1.1 eq) of triethyl borate,5.0 kg of 2-methyltetrahydrofuran was added to the reaction vessel, and heated to reflux for 3 hours.The TLC controlled raw material reacted completely to room temperature.595.0 g (5.88 mol, 3.0 eq) of triethylamine was added, and then 421.8 g (4.9 mol, 2.5 eq) of vinyl acetate was added, and the mixture was stirred at room temperature for 6 hours.The ratio of monoacetyl ganciclovirand N,O-diacetyl ganciclovir in the HPLC was 93/5, and the temperature was lowered by 0-10 °C.2.0 kg of ethanol was added dropwise, and the mixture was stirred at room temperature for 3 hours, and the solvent was concentrated under reduced pressure.It was washed once with 500 g of water, and the layers were separated.The ethanol was recrystallized to obtain 438.0 g of colorless crystals, the yield was 75.2percent, and the purity was 99.1percent. |
75.2% | Stage #1: With triethyl borate In 2-methyltetrahydrofuran for 3 h; Reflux Stage #2: With triethylamine In 2-methyltetrahydrofuran at 20℃; for 6 h; Stage #3: With ethanol In 2-methyltetrahydrofuran at 0 - 20℃; for 2 h; | 500.0g (1.96mol, 1.0eq) of ganciclovir, triethyl borate 314·7g (2·15mol, 1 · leq), 5.0kg of 2-methyltetrahydrofuran was added to the reaction kettle and heated to reflux for 3 hours. The TLC controlled material was completely reacted and cooled to room temperature. Triethylamine 595, 0 g (5.88 mol, 3 · Oeq) was added, then 421,8 g (4.9 mol, 2.5 eq) of vinyl acetate was added, and stirred at room temperature for 6 hours. The ratio of monoacetyl ganciclovir and N,0-diacetyl ganciclovir was 93/5, the temperature was lowered to 0~10 °C, 2.0kg of ethanol was added dropwise, and the mixture was stirred at room temperature for 3 hours, and concentrated under reduced pressure. The solvent ethyl acetate was added 3.0kg, once, partitioned with 500g water, 500g aqueous layer was extracted with ethyl acetate, the organic layers were combined and concentrated under reduced pressure, and recrystallized from ethanol to give colorless crystals 438.0g, 75.2percent yield, purity 99.1percent |
75.2% | Stage #1: With triethyl borate In 2-methyltetrahydrofuran for 3 h; Reflux Stage #2: With triethylamine In tetrahydrofuran at 20℃; for 6 h; Stage #3: With ethanol In tetrahydrofuran at 0 - 20℃; for 3 h; | 500.0 g (1.96 mol, 1.0 eq) of ganciclovir, 314.7 g (2.15 mol, 1.1 eq) of triethyl borate,5.0 kg of 2-methyltetrahydrofuran was added to the reaction kettle.Heat to reflux for 3 hours,The TLC controlled raw material reacted completely to room temperature.595.0 g (5.88 mol, 3.0 eq) of triethylamine was added, followed by the addition of 421.8 g (4.9 mol, 2.5 eq) of vinyl acetate.Stir at room temperature for 6 hours.The ratio of monoacetyl ganciclovir and N,O-diacetyl ganciclovir in the HPLC was 93/5.Cool down 0~10 °C,Add 2.0kg of ethanol,After the dropwise addition, stir at room temperature for 3 hours.The solvent was concentrated under reduced pressure.Add 3.0 kg of ethyl acetate,It was washed once with 500 g of water, and the layers were separated.Recrystallization of ethanol gave 438.0 g of colorless crystals.The yield is 75.2percent, the purity is 99.1percent |
75.2% | Stage #1: With triethyl borate In 2-methyltetrahydrofuran for 3 h; Reflux Stage #2: With triethylamine In 2-methyltetrahydrofuran at 20℃; for 6 h; | 500.0 g (1.96 mol, 1.0 eq) of ganciclovir, 314.7 g (2.15 mol, 1.1 eq) of triethyl borate, 5.0 kg of 2-methyltetrahydrofuran were added to the reaction kettle, and heated to reflux for 3 hours.The TLC controlled raw material reacted completely to room temperature.Add 595.0 g (5.88 mol, 3.0 eq) of triethylamine, then add 421.8 g (4.9 mol, 2.5 eq) of vinyl acetate, stir at room temperature for 6 hours, and control the monoacetyl ganciclovir and N, O-diacetyl in HPLC. The ratio of ciclovir was 93/5, the temperature was lowered by 0 to 10 ° C, 2.0 kg of ethanol was added dropwise, and the mixture was stirred at room temperature for 3 hours. The solvent was concentrated under reduced pressure. 3.0 kg of ethyl acetate was added and washed once with 500 g of water.The layers were separated, and the aqueous layer was evaporated.The ethanol was recrystallized to obtain 438.0 g of colorless crystals, yield 75.2percent.Purity 99.1percent, |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87% | With acetic acid; In water; methylamine; | Example 8 Preparation of 9-(1,3-dihydroxy-2-propoxymethyl)guanine 12 and 7-(1,3-dihydroxy-2-propoxymethyl)guanine 11 Compound 9 (8.0 g) was dissolved in 100 ml of aqueous methylamine (40percent) and gently refluxed for 1.5 hours, and then was evaporated to dryness to give a white solid. The solid was crystallized from 50 ml of water and 10 drops of acetic acid (to neutralize amine and remove the color) to give a white crystalline product 12 (4.63 g, 87percent). mp>300° (dec.); Rf 0.62 (CH3 OH:CHCl3 =1:1); UV (H2 O) pH7 lambdamax 251.5 (epsilon 10180), 272.0 (sh, epsilon 7500), pH2 lambdamax 253.5 (epsilon9840), pH 11 lambdamax 265.6 (epsilon 8060); 1 H NMR (DMSO-d6) delta 10.64 (s, 1H, AcNH, D2 O exchangeable), 7.80 (s, 1H, 8-H), 6.49 (s, 2H, NH2 D2 O exchangeable), 5.43 (s, 2H, 1'-H), 4.61 (t, 2H, OH, D2 O exchangeable), 3.55-3.28 (m, 5H, 4'-H, 5'-H, 3'-H). |
82.8% | With potassium hydroxide; at 70℃; for 0.5h;Microwave irradiation; | In the second step, the above-mentioned triacetyl ganciclovir compound (2) 67.1 g and 10percent potassium hydroxide solution 200 g are put into a microwave reactor.The temperature was raised to 70 ° C for 0.5 hour, cooled to room temperature, sulfuric acid was added to adjust the pH to neutrality, 3.3 g of activated carbon was added, and then dissolved.The mixture was decolorized by reflux at elevated temperature for 1 hour, filtered, and the filtrate was cooled to 10 ° C for crystallization.Filtration and drying gave 37.5 g of crude ganciclovir, the yield was 84.2percent, and the purity was 97.1percent. In the third step, 37.5 g of crude ganciclovir and 187 g of DMF were added to the reaction flask, and the mixture was heated to 90 ° C until stirred.Then cooled to 40 ° C, added 561g of methanol, and continued to cool to 20 ° C for 5 hours.Filtration, methanol washing, drying to obtain pure ganciclovir 31.0g, yield 82.8percent, purity 99.0percent, |
78% | With methanol; potassium hydroxide; at 20℃; for 12h; | 5 mmoles of acetyl-protected ganciclovir (4) and 20 mmol of KOH were stirred in 20 ml of methanol at room temperature for 12 hours, decolorized by activated carbon, filtered, and the solvent was distilled off under reduced pressure to obtain a viscous material. Recrystallization from water gave a white powder which was ganciclovir (6). The product yield was 78percent. |
With acetic acid; In methylamine; | C. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine A solution of 838 mg (2.2 mmole) of <strong>[86357-14-4]2-acetamido-9-(1,3-diacetoxy-2-propoxymethyl)hypoxanthine</strong> in 8.5 ml of 40percent methylamine (aqueous) was stirred at gentle reflux under N2 for 1 hour. The solution was then cooled and concentrated to dryness. The residual white solid was recrystallized from a minimum volume of H2 O containing 2 drops of acetic acid. After standing in the refrigerator, the product was collected on a filter and washed with a small amount of H2 O, then acetone. The material was dried under high vacuum at 75° for 3 hours to giive 529 mg (90percent based on hydration with 0.75H2 O) of white crystals, mp 249°-250° dec. The material was homogeneous by TLC (80:20:2 CHCl3 --MeOH--H2 O), and the structure was confirmed by NMR. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | With pyridine; for 6h;Reflux; | Ganciclovir (1.0 g, 4.0 mmol), acetic anhydride (5.0 ml, 53 mmol), and pyridine (10.0 ml) were heated together, under reflux, for 6 hours. Initially, the reaction mixture was not homogeneous but once reaction completed, all were in the solution. The reaction was cooled, treated with methanol (5.0 ml), stirred for 30 minutes at 25° C., and then concentrated under reduced pressure. The crude gummy product was purified by silica gel column chromatography using 4-6percent methanol/ dichloromethane 4 to provide tri-acetylated ganciclovir, 2 (1.2 g, 3.14 mmol, yield 80percent) as a colorless powdered. 1H NMR (CDCl3, 400 MHz): delta 12.02 (s, 1H), 9.49 (s, 1H), 7.84 (s, 1H), 5.55 (s, 2H), 4.19 (t, J=4.0 Hz, 4H), 4.12 (m, 1H), 2.35 (s, 3H), 2.05 (s, 6H). ESI-LC/MS: Expected [M+H]+ for C15H19N5O7 is 382.13, found m/z: 382.37 [M+H]+. |
Tags: 82410-32-0 synthesis path| 82410-32-0 SDS| 82410-32-0 COA| 82410-32-0 purity| 82410-32-0 application| 82410-32-0 NMR| 82410-32-0 COA| 82410-32-0 structure
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P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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