*Storage: Sealed in dry,Store in freezer, under -20°C.
*Shipping: Normal
4.5
*For Research Use Only !
Change View
Size | Price | USA Stock *0-1 Day | Global Stock *5-7 Days | In Stock |
250mg | łËǶÊÊ | Inquiry | Inquiry | Login |
1g | łËó¶ÊÊ | Inquiry | Inquiry | Login |
5g | łóî¶ÊÊ | Inquiry | Inquiry | Login |
25g | łÍÍͶÊÊ | Inquiry | Inquiry | Login |
Please Login or Create an Account to: See VIP prices and availability
łËǶÊÊ
łËó¶ÊÊ
łóî¶ÊÊ
łÍÍͶÊÊ
In Stock
- +
Please Login or Create an Account to: See VIP prices and availability
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 3543-74-6 |
Formula : | C18H27N3O4 |
M.W : | 349.43 |
SMILES Code : | O=C(OCC)CCCC1=NC2=CC(N(CCO)CCO)=CC=C2N1C |
MDL No. : | MFCD09840918 |
InChI Key : | SJYOJVBTSZGDQH-UHFFFAOYSA-N |
Pubchem ID : | 13086945 |
GHS Pictogram: | ![]() |
Signal Word: | Warning |
Hazard Statements: | H302 |
Precautionary Statements: | P280-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
76.2% | Example 9 Synthesis of 4-[5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazol-2-yl]butanoic acid (9, Bendamustine hydrochloride hydrate) 250 g (0.7154 mol) compound (7) was dissolved in 2000 ml methylene chloride and 212 g (1.78 mol) thionyl chloride added at -1 C. within a period of 30 minutes. Thereby the temperature rose briefly to ca. 4 C. Following addition the reaction solution was stirred for a further 30 minutes at -1 C. The solution was then stirred for ca. 16 h at ca. 22 C. Thereafter the solvent and excess thionyl chloride were removed by distillation under vacuum. To hydrolyse the ester the remaining residue (compound 8 as its hydrochloride) was treated with 2.6 kg 37% hydrochloric acid and 1.4 l water, heated to ca. 75 C. and held at this temperature for 30-40 minutes. 25 g activated carbon was then added and stirred for 10 minutes at 75 C. The solution was filtered and concentrated under vacuum. To crystallise crude compound (9) the residue was dissolved in 1000 ml water at ca. 55 C., the solution cooled to ca. -2 C. and then held at this temperature for ca. 30 minutes. The crude product (9) was filtered off, washed with 250 g water and 200 g acetone and dried for 2 h at ca. 35 C. under vacuum. The yield of crude compound (9) was 245 g (0.5936 mol) and had a water content of 4.5% (83% of theory). 245 g compound (9) were dissolved in 330 g 37% hydrochloric acid at ca. 40 C., treated with 1.28 kg water (temperature ca. 35 C.) and 650 g acetone (temperature ca. 35 C.) and stirred for 10 minutes. Crystallisation was initiated by the addition of 0.5 g Bendamustine hydrochloride hydrate, the mixture cooled within a period of 2 h to ca. -20 C. and then held at this temperature for ca. 90 minutes. The precipitate was filtered under suction. The crystals were washed initially with a mixture of 120 g water and 90 g acetone and subsequently with 275 g acetone. The pure Bendamustine hydrochloride hydrate was dried for ca. 2 h at ca. 35 C. under vacuum. Thus 225 g (0.545 mol) of pure (>99.8% content) compound (9) was obtained with an overall yield of 76.2% for this step. Through drying of the Bendamustine hydrochloride hydrate under vacuum at ca. 50 C. the water content could be adjusted to ca. 1% in contrast to 4.4% of the mono hydrates. | |
75% | HBI-ethylbutyrate (molecular weight = 349.42 g/mol) was dissolved in CHCI3 (10 x mass of HBI-ethylbutyrate). The solution was cooled to about 0 - 5 C and thionyl chloride (molecular weight = 118.96 g/mol, 2.11 equivalents) was added over 1 - 2 hours. After stirring for an additional 0.25 - 1 hour, the mixture was warmed to 25 +/- 5 C and stirred for an additional 20 - 24 hours. Aqueous hydrochloride acid (32%, 2.8 x mass of HBI-ethylbutyrate) was added and the organic phase was removed. The aqueous phase was degassed at 30 C for 15 - 30 minutes at 100-200 mbar). A suspension of active charcoal (0.02 x mass of HBI ethylbutyrate) in aqueous hydrochloric acid (0.2 x mass of HBI ethylbutyrate) was added to the aqueous phase. The mixture was heated to 85 - 90 C within 1 hour and stirred for 4 - 5 hours at reflux. After cooling, the suspension was filtered and rinsed with aqueous hydrochloric acid (0.2 x mass of HBI ethylbutyrate). The solvent was distilled under reduced pressure at an inner temperature of? 65 C. About seventy percent (+/-5%) of the total hydrochloric acid was distilled off. Warm (35-40 C) water (4x mass of HBI ethylbutyrate) was added. Seeding may be necessary if no crystallization occurs within 30 minutes. After crystallization, the thick suspension is cooled to about 15 - 25 C and stirred for 1 - 2 hours or overnight at? 15 - 25 C. The product is filtered, washed three times with water (0 - 5 C, total water = 4 x mass of HBI ethylbutyrate) and at least three times with acetone (0 - 5 C, total acetone = 4 x mass of HBI ethylbutyrate). The washed product was treated at least 4 times with acetone (2 x mass of HBI ethylbutyrate) at reflux for at least 1 hour. The hot suspension was filtered and the solid dried at? 35 - 40 C. Yield = 75 +/- 15% bendamustine hydrochloride. | |
Example 20: Preparation of crude Bendamustine hydrochloride (form B) [00103] A 5 L bottle was charged with 197 g of phosphorus oxychloride. The contents of the bottle were heated to 50 0C and 150 g of ethyl 4-{5-[bis(2- hydroxycthyl)amino]-l -methyl- lH-benzimidazol-2-yl}butanoatc("BBOH") dissolved in 600 ml of dichloromethane was added. Reaction mixture was stirred at 75-85 0C for 4-5 hours. The reaction mixture was then cooled to room temperature and diluted with 450 ml dichloromethane to form a solution. Then the solution was decomposed with 900 ml of 21 % hydrochloric acid and then this reaction mixture was heated at 92 - 96 C for 5-6 h. The resulting solution was then cooled, and its pH was adjusted with 50 % sodium hydroxide to a pH of 1.4 - 1.6 at 0 - 200C. The product crystallized and the mixture was stirred 30 - 60 minutes at 0-100C. The crude Bendamustine was separated by filtration and the filter cake was washed three times with 600 ml of cold dilute hydrochloric acid (1 :20), then three times with 600 ml of cold water, and then three times with 600 ml of ethyl acetate . The filter cake was then dried in wet (relative humidity over 30 %) nitrogen to give 144 g of crude bendamustine hydrochloride. |
Example 2:Preparation of bendamustine hydrochlorideTo a solution of lH-benzimidazol-l-methyl-5-N,N-di(2-hydroxyethyl)-2-butanoic acid ethyl ester (63 gm) as obtained in example 1 in dichloromethane (630 ml) was added thionyl chloride (50.4 gm) for 15 minutes at 0 to 5C. The contents were heated to 35 to 45C and then maintained for 2 hours 30 minutes. To the reaction mixture was added dichloromethane (1000 ml) and then the layers were separated. The aqueous layer was extracted with dichloromethane and combined the organic layers. The organic layer was treated with charcoal (5%, 5 gm) and the solvent was distilled off under vacuum to obtain a residual mass. The residual mass was dissolved in concentrated hydrochloric acid (630 ml) and then heated to 80 to 90C. The reaction mass was maintained for 3 hours at 80 to 90 C and the solvent was distilled off under vacuum to obtain a residual solid. To the residual solid was added water (125 ml), stirred for 20 minutes and filtered. The solid obtained was dried to give 54 gm of bendamustine hydrochloride.Chromatographic purity of bendamustine hydrochloride: 99.2%; andContent of 4-(7,8-dihydro-6-(2-chloroethylamino)-3-methyl-l,4-thiazino[3,2- g]benzimidazoyl(2))-butyric acid impurity: 0.5%. | ||
EXAMPLE-III Preparation of Bendamustine Hydrochloride (Formula-I) To a compound of formula IV (10 g) in dichloromethane (100 ml), thionyl chloride (20 ml) is charged slowly at 0-5 C. and then allowed to reflux. The reaction is distilled to dryness and then 100 ml conc. HCl is charged to the reaction. The temperature is raised to 80-90 C. and maintained for 6-8 h. The mass is treated with activated carbon, filtered and distilled to give the title product, which is washed with acetone (100 ml). | ||
54 g | Example 2 Preparation of Bendamustine Hydrochloride To a solution of 1H-benzimidazol-1-methyl-5-N,N-di(2-hydroxyethyl)-2-butanoic acid ethyl ester (63 gm) as obtained in example 1 in dichloromethane (630 ml) was added thionyl chloride (50.4 gm) for 15 minutes at 0 to 5 C. The contents were heated to 35 to 45 C. and then maintained for 2 hours 30 minutes. To the reaction mixture was added dichloromethane (1000 ml) and then the layers were separated. The aqueous layer was extracted with dichloromethane and combined the organic layers. The organic layer was treated with charcoal (5%, 5 gm) and the solvent was ,distilled off under vacuum to obtain a residual mass. The residual mass was dissolved in concentrated hydrochloric acid (630 ml) and then heated to 80 to 90 C. The reaction mass was maintained for 3 hours at 80 to 90 C. and the solvent was distilled off under vacuum to obtain a residual solid. To the residual solid was added water (125 ml), stirred for 20 minutes and filtered. The solid obtained was dried to give 54 gm of bendamustine hydrochloride. | |
Preparation of Bendamustine Hydrochloride (Crude) (0099) Step 1: 4-{5-[Bis-(2-hydroxy-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyric acid ethyl ester (27.0 kg) was dissolved in 270 kg chloroform. After cooling to 0 to 5 C., 19.2 kg thionyl chloride was added over about 1 hour. The mixture was warmed to 25 C.±5 C. and stirred for 20 to 24 hours. 75.6 kg hydrochloric acid (32% aqueous solution) was then added. After phase separation, the organic (lower) phase was removed. The product remained in the aqueous phase. (0100) Step 2: A suspension of activated charcoal in hydrochloric acid was added to the aqueous phase obtained in step 1. The mixture was heated over 1 hour to 85 to 90 C. and stirred for 4 to 5 hours at reflux. The suspension was then filtered and rinsed with aqueous hydrochloric acid. The solvent was distilled off under reduced pressure at a temperature not exceeding 65 C. 108 kg to 324 kg (108 kg preferred) of warm (35 to 45 C.) deionized water was added to induce crystallization. (0101) After crystallization, the mixture was cooled to 20 C±5 C. and stirred for an additional 1 to 2 hours or overnight. The product was collected by filtration on a filter dryer, washed with three portions each of 108 to 324 kg (108 kg preferred) deionized water and 108 to 216 kg (108 kg preferred) of cold acetone. The crude product was treated four times each with 54 to 108 kg (54 kg preferred) acetone at reflux for at least 1 hour, in the filter dryer. The suspension was filtered and the product dried at a temperature not higher than 40 C. under reduced pressure, to give 21.4 kg±2.1 kg bendamustine hydrochloride crude (70%±10%, calculated as dried substance). (0102) Step 3 (optional): The product obtained from step 2 was dissolved in hydrochloric acid (32% aqueous solution) and heated to reflux (85 to 90 C.) for at least 4 hours. To improve color, activated charcoal can be added to the hydrochloric acid and the mixture heated to reflux (85 to 90 C.) for at least 4 hours. With activated charcoal, the suspension was filtered and rinsed with aqueous hydrochloric acid. Solvent was distilled off under reduced pressure at a temperature not exceeding 65 C. The mixture was then diluted with deionized water. If no crystallization occurred within 15 min, the mixture was seeded. After crystallization, the suspension was stirred at 40 C.±5 C. for one hour, then cooled to 20 C.±5 C. After stirring an additional 1 to 2 hours at 20 C.±5 C., the product was collected by filtration, washed three times with cold deionized water, and at least three times with cold acetone. The crude product was treated four times with acetone at reflux for at least 1 hour. The suspension was filtered and the product dried at a temperature not higher than 40 C., under reduced pressure. Yield was of crude bendamustine hydrochloride was 80%±10%. Preparation of Purified Bendamustine Hydrochloride (0103) Bendamustine HCl crude (15.0 kg) was suspended with 0.45 kg activated charcoal in ethanol/water (vol/vol=97/3) at room temperature. The mixture was quickly warmed to 75 to 80 C. and stirred for not more than 10 min under reflux conditions. The mixture was filtered to remove the activated charcoal. After filtration, 33.0 kg of filtered acetone was added quickly at 40-50 C. to induce crystallization. (0104) After crystallization, the mixture was stirred for 30 to 60 min at 40-50 C., then cooled to 0 to 5 C., and stirred for at least an additional 30 min or overnight. The product was collected by filtration and washed with three 45 kg of cold acetone. After that, the crude product was treated 4 times each with 30 kg acetone at reflux for at least 1 hour. The suspension was filtered and the product dried at a temperature not higher than 40 C. under reduced pressure providing 11.3±1.5 kg bendamustine hydrochloride (75%±10%). |
Tags: 3543-74-6 synthesis path| 3543-74-6 SDS| 3543-74-6 COA| 3543-74-6 purity| 3543-74-6 application| 3543-74-6 NMR| 3543-74-6 COA| 3543-74-6 structure
A408667 [533928-74-4]
2,6-Bis(1-methyl-1H-benzo[d]imidazol-2-yl)pyridin-4-ol
Similarity: 0.63
A106986 [4589-66-6]
(1,2-Dimethyl-1H-benzo[d]imidazol-5-yl)methanol
Similarity: 0.63
A176136 [20034-02-0]
(6-Methyl-1H-benzo[d]imidazol-2-yl)methanol
Similarity: 0.61
A290767 [933697-27-9]
2-(2-Aminoethyl)-1H-benzo[d]imidazol-4-ol
Similarity: 0.61
A115126 [173530-73-9]
Ethyl 8-hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxylate
Similarity: 0.59
A128291 [3543-73-5]
Ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate
Similarity: 0.98
A108739 [402948-37-2]
Ethyl 2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate
Similarity: 0.86
A107432 [1865-09-4]
Ethyl 1H-benzo[d]imidazole-2-carboxylate
Similarity: 0.71
A122333 [N/A]
Methyl 5-amino-1H-benzo[d]imidazole-2-carboxylate hydrochloride-Deleted-NAME
Similarity: 0.69
A272959 [5805-53-8]
Methyl 1H-benzo[d]imidazole-2-carboxylate
Similarity: 0.68
A128291 [3543-73-5]
Ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate
Similarity: 0.98
A122333 [N/A]
Methyl 5-amino-1H-benzo[d]imidazole-2-carboxylate hydrochloride-Deleted-NAME
Similarity: 0.69
A523874 [29518-68-1]
2-(1H-Benzo[d]imidazol-2-yl)ethanamine
Similarity: 0.65
A322510 [88704-72-7]
2-(1H-Benzo[d]imidazol-2-yl)ethanamine hydrochloride
Similarity: 0.64
A377466 [4499-07-4]
2-(1H-Benzo[d]imidazol-2-yl)ethanamine dihydrochloride
Similarity: 0.64
A128291 [3543-73-5]
Ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate
Similarity: 0.98
A108739 [402948-37-2]
Ethyl 2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate
Similarity: 0.86
A230525 [1841081-72-8]
1-(2-Ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole hydrochloride
Similarity: 0.78
A343735 [1181267-36-6]
tert-Butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate
Similarity: 0.71
A107432 [1865-09-4]
Ethyl 1H-benzo[d]imidazole-2-carboxylate
Similarity: 0.71
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :
Total Compounds: mg
The concentration of the dissolution solution you need to prepare is mg/mL