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Chemical Structure| 24277-39-2 Chemical Structure| 24277-39-2
Chemical Structure| 24277-39-2

*Storage: Sealed in dry,Store in freezer, under -20°C.

Boc-Glu-OtBu

CAS No.: 24277-39-2

Synonyms: Boc-Glu-OtBu

4.5 *For Research Use Only !

Cat. No.: A297281 Purity: 98%

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Product Details of [ 24277-39-2 ]

CAS No. :24277-39-2
Formula : C14H25NO6
Linear Structure Formula :(CH3)3COCONHCH(COOC(CH3)3)(CH2)2COOH
M.W : 303.35
SMILES Code : O=C(O)CC[C@H](NC(OC(C)(C)C)=O)C(OC(C)(C)C)=O
Synonyms :
Boc-Glu-OtBu
MDL No. :MFCD00038273

Safety of [ 24277-39-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis [ 24277-39-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 24277-39-2 ]

[ 24277-39-2 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 5672-83-3 ]
  • [ 24277-39-2 ]
  • [ 157886-31-2 ]
  • [ 73872-73-8 ]
  • [ 63061-86-9 ]
  • 2
  • [ 24277-39-2 ]
  • [ 24835-08-3 ]
  • N-(tert-Butoxycarbonyl)-N'-(2-nitrobenzyl)-L-glutamine α-tert-butyl ester [ No CAS ]
  • 4
  • [ 24277-39-2 ]
  • [ 91229-86-6 ]
  • 5
  • [ 7724-12-1 ]
  • [ 24277-39-2 ]
  • tert-butyl N2-(tert-butoxycarbonyl)-N5-(2-cyanobenzo[d]thiazol-6-yl)glutaminate [ No CAS ]
YieldReaction ConditionsOperation in experiment
60% solution of Boc-Glu-OtBu ( 303 mg, 1.0 mmol) was added N-methylmorpholine (82 muL, 1.0 mmol) and i-BuOCOCl (112 muL, 2.0 mmol) in tetrahydrofuran (2 mL), the mixture was stirred at 0 °C for 0.5 h. Then <strong>[7724-12-1]2-cyano-6-aminobenzothiazole</strong> (87 mg, 0.5mmol) in 2ml tetrahydrofuan was added. The mixture was stirred at room temperature overnight. Then the solution was evaporated under reduced pressure. The mixture was diluted with ethyl acetate and (50 mL) washed with saturated sodium bicarbonate solution, water and brine, dried over anhydrous MgSO4 and filtered. The crude product was purified by chromatography with ethyl acetate?hexane (1:2) as the eluents to afford a white solid, 83 mg, yield = 60percent. 1H-NMR (400 MHz, CDCl3) delta 9.87 (s, 1H), 8.79 (s, 1H), 8.12 (d, J = 8.9 Hz, 1H), 7.57 (d, J = 8.8 Hz, 1H), 5.48 (d, J = 7.8 Hz, 1H), 4.30 ? 4.17 (m, 1H), 2.58 ? 2.45 (m, 2H), 2.30 (m, J = 10.3, 7.1, 3.3 Hz, 1H), 1.85 (m, J = 16.2, 10.7, 4.7 Hz, 1H), 1.51 (s, 9H), 1.46 (s, 9H).
 

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