Home Cart Sign in  
Chemical Structure| 864750-70-9 Chemical Structure| 864750-70-9
Chemical Structure| 864750-70-9

Revefenacin

CAS No.: 864750-70-9

Revefenacin (TD-4208) is a long-acting muscarinic cholinergic receptor antagonist with a Ki of 0.18 nM for the M3 receptor, selectively acting on the lungs, and used for treating respiratory diseases.

Synonyms: TD-4208;GSK1160724

4.5 *For Research Use Only !

Cat. No.: A642503 Purity: 98+%

Change View

Size Price

USA Stock *0-1 Day

Global Stock *5-7 Days

In Stock
1mg łÇď¶ÊÊ Inquiry Inquiry
2mg łËǶÊÊ Inquiry Inquiry
5mg łËò¶ÊÊ Inquiry Inquiry
10mg łÍʶÊÊ Inquiry Inquiry
25mg łďò¶ÊÊ Inquiry Inquiry
50mg łÇËò¶ÊÊ Inquiry Inquiry
100mg łËÇͶÊÊ Inquiry Inquiry
250mg ł§ò§¶ÊÊ Inquiry Inquiry
1g łÇ§Êÿ¶ÊÊ Inquiry Inquiry

  • 1mg

    łÇď¶ÊÊ

  • 2mg

    łËǶÊÊ

  • 5mg

    łËò¶ÊÊ

  • 10mg

    łÍʶÊÊ

  • 25mg

    łďò¶ÊÊ

  • 50mg

    łÇËò¶ÊÊ

  • 100mg

    łËÇͶÊÊ

  • 250mg

    ł§ò§¶ÊÊ

  • 1g

    łÇ§Êÿ¶ÊÊ

In Stock

- +

  • 1-2 Day Shipping
  • High Quality
  • Technical Support Online Technical Q&A
Product Citations

Product Details of [ Revefenacin ]

CAS No. :864750-70-9
Formula : C35H43N5O4
M.W : 597.75
SMILES Code : O=C(OC1CCN(CCN(C(C2=CC=C(CN3CCC(C(N)=O)CC3)C=C2)=O)C)CC1)NC4=CC=CC=C4C5=CC=CC=C5
Synonyms :
TD-4208;GSK1160724
MDL No. :MFCD28386316
InChI Key :FYDWDCIFZSGNBU-UHFFFAOYSA-N
Pubchem ID :11753673

Safety of [ Revefenacin ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

ALK Isoform Comparison

Name AChE AChR mAChR nAChR Purity
Donepezil +++

hAChE, IC50: 11.6 nM

bAChE, IC50: 8.12 nM

98%
Loganin ++

AChE, IC50: 3.95 μM

98%
topride HCl ++

AChE, IC50: 2.04 μM

98%
Dehydroevodiamine HCl 95%
Jatrorrhizine ++

AChE, IC50: 872 nM

98%
(-)-Huperzine A ++++

AChE (G4 form), Ki: 7 nM

98%
Galanthamine HBr ++

AChE, IC50: 0.35 μM

98%
Trospium chloride 99%
Gallamine Triethiodide +

AChR, IC50: 68.0 μM

98%
Hexamethonium Bromide 99%
Neostigmine bromide 98%
Oxybutynin 98%
Irsogladine 99%
Pyridostigmine bromide 99+%
Rivastigmine +

AChR, IC50: 5.5 μM

98%
Tropicamide +++

M4 mAChR, IC50: 8 nM

98%
Diphenmanil methylsulfate 99%
Umeclidinium bromide 95%
Otilonium bromide 98%
Flavoxate HCl +

mAChR, IC50: 12.2 μM

99%
Ipratropium bromide 98%
Diphenidol HCl 98%
Darifenacin hydrobromide ++++

M3 mAChR, pKi: 8.9

98%
Aclidinium Bromide ++++

M4 mAChR, Ki: 0.21 nM

M2 mAChR, Ki: 0.1 nM

98%
Oxybutynin chloride 99%
Solifenacin 98%
Benzethonium chloride +++

α7 nAChRs, IC50: 122 nM

α4β2 nAChRs, IC50: 49 nM

99+%
PNU-120596 ++

α7 nAChR, EC50: 216 nM

99+%

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT03095456 Chronic Obstructive Pulmonary ... More >>Disease, COPD Low Peak Inspiratory Flow Rate (PIFR) Less << Phase 3 Completed - United States, South Carolina ... More >> Clinical Research of Rock Hill Rock Hill, South Carolina, United States, 29732 Less <<
NCT03573817 Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << Phase 3 Completed - United States, Oregon ... More >> Theravance Biopharma Call Center Medford, Oregon, United States, 97504 Less <<
NCT01704404 - Completed - -
NCT02040792 COPD Phase 2 Completed - United States, South Carolina ... More >> Upstate Pharmaceutical Research Greenville, South Carolina, United States, 29615 Less <<
NCT02820311 Cardiac Repolarization in Heal... More >>thy Subjects Less << Phase 1 Completed - United States, Arizona ... More >> Celerion Tempe, Arizona, United States, 85283 Less <<
NCT02459080 Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << Phase 3 Completed - United States, Oregon ... More >> Allergy Associates Research Center (AARC) Portland, Oregon, United States, 97202 Less <<
NCT01704404 COPD Phase 2 Completed - New Zealand ... More >> P3 Research Ltd Wellington, New Zealand Less <<
NCT02512510 Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << Phase 3 Completed - United States, South Carolina ... More >> Palmetto Medical Research Associates L.L.C. Easley, South Carolina, United States, 29640 Less <<
NCT02518139 Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << Phase 3 Completed - United States, South Carolina ... More >> Palmetto Medical Research Associates L.L.C Easley, South Carolina, United States, 29640 Less <<
NCT03064113 Chronic Obstructive Pulmonary ... More >>Disease, COPD Less << Phase 2 Completed - New Zealand ... More >> P3 Research Wellington, New Zealand, 6021 Less <<
NCT02040792 - Completed - -
NCT02772159 Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << PHASE1 COMPLETED 2025-04-16 Celerion, Lincoln, Nebraska, 6... More >>8502, United States Less <<
NCT02578082 Renal Impairment PHASE1 COMPLETED 2025-05-16 Orlando Clinical Research Cent... More >>er (OCRC), Orlando, Florida, 32809, United States Less <<
NCT02109172 - Completed - -
NCT02581592 Hepatic Impairment PHASE1 COMPLETED 2025-04-16 Orlando Clinical Research Cent... More >>er (OCRD), Orlando, Florida, 32809, United States Less <<
NCT02109172 Chronic Obstructive Pulmonary ... More >>Disease COPD Less << Phase 2 Completed - United States, North Carolina ... More >> American Health Research Charlotte, North Carolina, United States, 28207 Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.67mL

0.33mL

0.17mL

8.36mL

1.67mL

0.84mL

16.73mL

3.35mL

1.67mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

Historical Records

Categories