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Chemical Structure| 837422-57-8 Chemical Structure| 837422-57-8
Chemical Structure| 837422-57-8

*Storage: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C.

WH-4-023

CAS No.: 837422-57-8

WH-4-023 is a selective Lck/Src kinase inhibitor with IC50 values of 2 nM and 6 nM, respectively. It has weaker inhibition on p38α and KDR, and effectively inhibits SIK with IC50 values of 10, 22, and 60 nM.

Synonyms: Dual LCK/SRC inhibitor;KIN001-112;KIN112

4.5 *For Research Use Only !

Cat. No.: A135851 Purity: 99%

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Product Details of [ WH-4-023 ]

CAS No. :837422-57-8
Formula : C32H36N6O4
M.W : 568.67
SMILES Code : O=C(OC1=C(C)C=CC=C1C)N(C2=CC=C(OC)C=C2OC)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=NC=C3
Synonyms :
Dual LCK/SRC inhibitor;KIN001-112;KIN112
MDL No. :MFCD28138072
InChI Key :NBTNHSGBRGTFJS-UHFFFAOYSA-N
Pubchem ID :11844351

Safety of [ WH-4-023 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Biological Activity

Target
  • Src

    Src, IC50:6 nM

  • Lck

    Lck, IC50:2 nM

  • Cav 2.2

    Cav 2.2, IC50:0.001 μM

  • Calcium Channel

    Cav 2.2, IC50:0.001 μM

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.76mL

0.35mL

0.18mL

8.79mL

1.76mL

0.88mL

17.59mL

3.52mL

1.76mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline
Solubility: ≥ 0.77 mg/mL (1.35 mM); Clear solution
Protocol 2
Add each solvent one by one:  10% DMSO    90% Corn Oil
Solubility: ≥ 0.77 mg/mL (1.35 mM); Clear solution

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