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Chemical Structure| 364782-34-3 Chemical Structure| 364782-34-3
Chemical Structure| 364782-34-3

*Storage: Inert atmosphere,Room Temperature.

Cinacalcet HCl

CAS No.: 364782-34-3

Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of the Ca receptor (CaR), used for treating cardiovascular diseases.

Synonyms: AMG-073 hydrochloride;Cinacalcet (hydrochloride);Mimpara

4.5 *For Research Use Only !

Cat. No.: A164114 Purity: 98%

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Product Details of [ Cinacalcet HCl ]

CAS No. :364782-34-3
Formula : C22H23ClF3N
M.W : 393.87
SMILES Code : FC(C1=CC(CCCN[C@@H](C2=C3C=CC=CC3=CC=C2)C)=CC=C1)(F)F.[H]Cl
Synonyms :
AMG-073 hydrochloride;Cinacalcet (hydrochloride);Mimpara
InChI Key :QANQWUQOEJZMLL-PKLMIRHRSA-N
Pubchem ID :156418

Safety of [ Cinacalcet HCl ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of [ Cinacalcet HCl ]

GPCR

ALK Isoform Comparison

Name CaSR Purity
NPS-2143 ++++

Ca(2+) receptor, IC50: 43 nM

98+%

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01100723 - Completed - -
NCT02464072 Hyperparathyroidism, Secondary Not Applicable Active, not recruiting July 2019 Brazil ... More >> University of Sao Paulo General Hospital Sao Paulo, SP, Brazil Less <<
NCT01073462 - Completed - Austria ... More >> Site Reference ID/Investigator# 27447 Graz, Austria, 8010 Site Reference ID/Investigator# 49182 Graz, Austria, 8020 Site Reference ID/Investigator# 27483 Graz, Austria, 80360 Site Reference ID/Investigator# 52742 Graz, Austria, 8052 Site Reference ID/Investigator# 27487 Innsbruck, Austria, 6020 Site Reference ID/Investigator# 36983 Linz, Austria, 4010 Site Reference ID/Investigator# 27484 Linz, Austria, 4020 Site Reference ID/Investigator# 27485 Rottenmann, Austria, 8786 Site Reference ID/Investigator# 27446 Vienna, Austria, 1030 Site Reference ID/Investigator# 53469 Vienna, Austria, 1090 Site Reference ID/Investigator# 27482 Vienna, Austria, 1130 Site Reference ID/Investigator# 10981 Vienna, Austria, 1220 Less <<
NCT02102204 Hyperparathyroidism, Secondary Phase 3 Completed - -
NCT01717989 - Completed - -
NCT01073462 - Completed - -
NCT02273570 Hyperparathyroidism, Secondary Not Applicable Unknown March 2017 Italy ... More >> Azienda Ospedaliera Sant'Anna Recruiting San Fermo della battaglia (CO), Italy, 22020 Contact: Simona Urbano    +39.031.585.8947    comitato.etica@hsacomo.org    Principal Investigator: Antonio Bellasi, MD          Principal Investigator: Claudio Minoretti, MD Less <<
NCT03527511 - Recruiting May 14, 2020 France ... More >> Service de Néphrologie, Rhumatologie et Dermatologie Pédiatriques - Hôpital Femme Mère Enfant - Bron. Recruiting Bron, France, 69677 Contact: Justine BACCHETTA, Pr    04 27 85 61 30 ext +33    justine.bacchetta@chu-lyon.fr    Principal Investigator: Justine BACCHETTA, Pr          Sub-Investigator: Bruno RANCHIN, Dr          Sub-Investigator: Anne-Laure SELIER-LECLERC, Dr          Sub-Investigator: Aurélia BERTHOLET-THOMAS, Dr          Sub-Investigator: Elodie CHEYSSAC, Dr          Sub-Investigator: Corentin TANNE, Dr Less <<
NCT02102204 - Completed - -
NCT01421407 Secondary Hyperparathyroidism ... More >> End Stage Renal Disease Parathyroid Hyperplasia Less << Not Applicable Withdrawn - Italy ... More >> Ospedale generale regionale "Miulli" Acquaviva delle Fonti, Italy, 70021 Ospedale Maggiore Policlinico Mangiagalli e Regina Elena Milano, Italy, 20122 Spain Hospital Universitario Marquès de Valdecilla Santander, Cantabria, Spain, 39008 Less <<
NCT03603444 - Completed - Italy ... More >> Azienda Ospedaliero - Universitaria di Modena Modena, Italy, 41124 Less <<
NCT00656032 End Stage Renal Disease Phase 2 Completed - United States, Tennessee ... More >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232 Less <<
NCT02440581 Kidney Failure, Chronic Not Applicable Recruiting June 2020 United States, Kentucky ... More >> University of Kentucky Recruiting Lexington, Kentucky, United States, 40536 Contact: Nedda Hughes, PA    859-218-1509    nkhugh1@uky.edu    Contact: Tara Spach    859-323-2672    tara.spach@uky.edu Less <<
NCT00189501 - Completed - -
NCT00110656 - Completed - -
NCT01011699 Chronic Renal Failure ... More >> Hemodialysis Less << Phase 3 Terminated(Financial problem) - France ... More >> Centre Hospitalier Général Soissons, Aisne, France, 02009 Centre Hospitalier Lisieux, Calvados, France, 14100 ALURAD Limoges, Limousin, France, 87042 Centre Hospitalier Universitaire Reims, Marne, France, 51092 Association Régionale Promotion Dialyse à domicile (ARPDD) Reims, Marne, France Association pour le Développement de l'Hémodialyse Hénin-Beaumont, Nord-Pas de Calais, France, 62110 Polyclinique de la Louvière Lille, Nord, France, 59000 CHRU Lille, Nord, France, 59037 Hôpital Victor Provo Roubaix, Nord, France, 59056 Centre Hospitalier Général Valenciennes, Nord, France, 59322 Centre Hospitalier Général Beauvais, Oise, France, 60000 Clinique Saint Côme Compiegne, Oise, France, 60200 Centre Hospitalier Général Creil, Oise, France, 60100 Clinique du Bois Bernard Bois Bernard, Pas de calais, France, 62320 Centre Hospitalier Boulogne sur mer, Pas de calais, France, 62200 Centre Hospital-Universitaire d'Amiens Amiens, Picardie, France, 80054 Clinique de l'Europe Rouen, Seine maritime, France, 76040 Centre Hospitalier Cambrai, France, 59407 Less <<
NCT02525796 Primary Hyperparathyroidism Phase 2 Phase 3 Recruiting December 2020 United States, Massachusetts ... More >> Brigham and Women's Hospital Recruiting Boston, Massachusetts, United States, 02115 Contact: Molly Connors    617-732-5186 Less <<
NCT02216656 Secondary Hyperparathyroidism Phase 2 Completed - Japan ... More >> For additional information regarding investigative sites for this trial, contact Kyowa Hakko Kirin Tokyo, Japan Less <<
NCT00042432 - Completed - -
NCT01932970 Hyperparathyroidism, Secondary Phase 3 Completed - -
NCT01932970 - Completed - -
NCT00037518 Hyperparathyroidism ... More >> Parathyroid Neoplasms Less << Phase 4 Completed - -
NCT01100723 Secondary Hyperparathyroidism ... More >> Chronic Kidney Disease Less << Phase 4 Completed - United States, Virginia ... More >> Lynchburg Nephrology Associates, P.L.L.C. Lynchburg, Virginia, United States, 24501 Less <<
NCT00325104 Hypercalcemia ... More >> Familial Primary Hyperparathyroidism Less << Phase 3 Completed - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT02133404 Secondary Hyperparathyroidism Phase 2 Completed - Japan ... More >> Chubu, Japan Chugoku, Japan Kanto, Japan Kyushu, Japan Shikoku, Japan Tohoku, Japan Less <<
NCT00037635 Secondary Hyperparathyroidism ... More >> End Stage Renal Disease Less << Phase 3 Completed - -
NCT00395902 - Completed - -
NCT01599962 Memory Functions Phase 2 Completed - Switzerland ... More >> University of Basel, Division of Cognitive Neuroscience Basel, Switzerland, 4055 Less <<
NCT01717989 - Completed - -
NCT00261950 Secondary Hyperparathyroidism Phase 2 Completed - -
NCT01748812 Osteomalacia Phase 1 Terminated - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT00336739 Healthy Not Applicable Completed - United States, Massachusetts ... More >> Human Nutrition Research Center on Aging at Tufts University Boston, Massachusetts, United States, 02111 Less <<
NCT01573520 Hyperparathyroidism ... More >> Chronic Kidney Disease Less << Phase 4 Completed - Switzerland ... More >> Centre Hospitalier Universitaire Vaudois Lausanne, Switzerland, 1011 Less <<
NCT00042432 Secondary Hyperparathyroidism ... More >> Chronic Renal Insufficiency Less << Phase 2 Completed - -
NCT00042653 Secondary Hyperparathyroidism ... More >> End Stage Renal Disease Less << Phase 3 Completed - -
NCT00132431 Kidney Disease ... More >> Secondary Hyperparathyroidism Chronic Kidney Disease Less << Phase 4 Completed - -
NCT00261950 - Completed - -
NCT00110890 End Stage Renal Disease Phase 4 Completed - -
NCT00113958 End Stage Renal Disease Phase 2 Completed - -
NCT00113945 End Stage Renal Disease Phase 2 Completed - -
NCT00110929 End Stage Renal Disease Phase 2 Completed - -
NCT00110890 - Completed - -
NCT01181531 Hyperparathyroidism, Secondary Phase 4 Completed - -
NCT02227264 Primary Hyperparathyroidism Not Applicable Unknown December 2016 Sweden ... More >> Karolinska University Hospital Recruiting Stockholm, Sweden, 171 76 Contact: Inga-Lena Nilsson, Assoc.prof.       inga-lena.nilsson@ki.se Less <<
NCT00446329 Secondary Hyperparathyroidism Phase 4 Terminated(due to financial pr... More >>oblems) Less << - Greece ... More >> Papageorgiou General Hospital Thessaloniki, Greece, 56403 Less <<
NCT00415584 Secondary Hyperparathyroidism|... More >>Hypercalcemia Less << PHASE1|PHASE2 TERMINATED 2025-11-09 Montefiore Medical Center, Bro... More >>nx, New York, 10467, United States Less <<
NCT00094484 Kidney Disease|Chronic Kidney ... More >>Disease Less << PHASE3 COMPLETED - -
NCT00803712 Chronic Kidney Disease ... More >> Secondary Hyperparathyroidism Less << Phase 4 Completed - -
NCT00803712 - Completed - -
NCT00936650 Hyperparathyroidism, Primary Phase 2 Completed - -
NCT00975000 Chronic Allograft Nephropathy ... More >> Chronic Kidney Disease Chronic Renal Failure Disordered Mineral Metabolism End Stage Renal Disease Hyperparathyroidism Hypophosphatemia Kidney Disease Kidney Transplantation Post Renal Transplantation Less << Phase 3 Completed - -
NCT01250405 Chronic Kidney Disease Phase 4 Completed - Canada, Quebec ... More >> Karine Marquis Québec, Quebec, Canada, G1R2J6 Less <<
NCT00195936 Hypophosphatemic Rickets, X-Li... More >>nked Dominant Less << Phase 1 Unknown - United States, Missouri ... More >> Section of Pediatric Nephrology, Children's Mercy Hospitals and Clinics Recruiting Kansas City, Missouri, United States, 64108 Principal Investigator: Rachel Levy-Olomucki, MD Less <<
NCT01181531 - Completed - -
NCT00975000 - Completed - -
NCT00135304 Secondary Hyperparathyroidism Phase 4 Completed - -
NCT03027557 Primary Hyperparathyroidism ... More >> Parathyroid Adenoma Parathyroid Hyperplasia Less << Phase 3 Enrolling by invitation March 30, 2019 Denmark ... More >> Aalborg University Hospital Aalborg, Denmark, 9000 Less <<
NCT01178450 Secondary Hyperparathyroidism Phase 4 Completed - Spain ... More >> Hospital Universitari de Bellvitge L'Hospitalet de Llobregat, Barcelone, Spain, 08907 Hospital Clinic de Barcelona Barcelona, Spain, 08036 Less <<
NCT01277510 - Terminated(Study was suspended... More >> in agreement between sponsor and FDA due to concerns about the study design after a fatality had occurred in the presence of hypocalcemia.) Less << - -
NCT00977080 - Completed - -
NCT01277510 Chronic Kidney Disease ... More >> Hyperparathyroidism Hyperparathyroidism, Secondary Kidney Disease Secondary Hyperparathyroidism Less << Phase 3 Terminated(Study was suspended... More >> in agreement between sponsor and FDA due to concerns about the study design after a fatality had occurred in the presence of hypocalcemia.) Less << - -
NCT00928408 - Completed - -
NCT00928408 - Completed - -
NCT00117052 Secondary Hyperparathyroidism ... More >> End Stage Renal Disease Less << Phase 3 Completed - -
NCT00977080 Chronic Kidney Disease ... More >> Secondary Hyperparathyroidism Hemodialysis Less << Phase 4 Completed - -
NCT01447368 Kidney Failure ... More >> Secondary Hyperparathyroidism Vascular Diseases Less << Not Applicable Recruiting December 2017 Hong Kong ... More >> Queen Mary Hospital and Tung Wah Hospital Recruiting Hong Kong, Hong Kong, 0000 Contact: Angela YM Wang, MD, PhD    852-22554949    aymwang@hku.hk    Principal Investigator: Angela YM Wang, MD, PhD          Sub-Investigator: Wai-Kei Lo, FRCP Less <<
NCT00527085 Renal Osteodystrophy Phase 2 Completed - -
NCT00345839 Secondary Hyperparathyroidism ... More >> Chronic Kidney Disease Less << Phase 3 Completed - -
NCT00379899 - Completed - -
NCT01460030 Parathyroid Carcinoma|Hypercal... More >>cemia|Primary Hyperparathyroidism Less << PHASE3 COMPLETED 2025-02-13 Sendai, Japan
NCT01101113 Secondary Hyperparathyroidism Phase 4 Completed - Korea, Republic of ... More >> Seoul National University Hospital Seoul, Korea, Korea, Republic of, 110-744 Kyungpook National University Daegu, Korea, Republic of Gil Hospital Incheon, Korea, Republic of Hallym University Sacred Hospital Pyungchon, Korea, Republic of Seoul National University Bundang Hospital Seongnam, Korea, Republic of Eulji University Seoul, Korea, Republic of Samsung Medical Center Seoul, Korea, Republic of Less <<
NCT00379899 Chronic Kidney Disease ... More >> End Stage Renal Disease Coronary Artery Calcification Vascular Calcification Calcification Cardiovascular Disease Chronic Renal Failure Hyperparathyroidism Kidney Disease Nephrology Secondary Hyperparathyroidism Less << Phase 4 Completed - -
NCT01896232 - Completed - -
NCT00936988 Hyperparathyroidism, Primary Phase 2 Completed - -
NCT00975221 Hyperparathyroidism, Primary ... More >> Hypercalcemia Less << Phase 3 Completed - -
NCT00527267 Hyperparathyroidism Phase 3 Completed - -
NCT01896232 Secondary Hyperparathyroidism ... More >> Chronic Kidney Disease Less << Phase 3 Completed - -
NCT01103206 Parathyroid Hormone Suppressio... More >>n Test With Cinacalcet Less << Phase 4 Completed - France ... More >> University hospital Rouen, Haute Normandie, France, 76031 Less <<
NCT00975221 - Completed - -
NCT01519037 Relationship Between Calcimime... More >>tic and the RAAS Less << Not Applicable Completed - Switzerland ... More >> CHUV, service de néphrologie/hypertension Lausanne, Vaud, Switzerland, 1011 Less <<
NCT03774771 Primary Hyperparathyroidism Phase 2 Completed - -
NCT02138838 Chronic Kidney Disease, Second... More >>ary Hyperparathyroidism Less << Phase 3 Terminated(Sponsor decision) - -
NCT00844740 Familial Hypophosphatemic Rick... More >>ets Less << Not Applicable Unknown - United States, Missouri ... More >> Children's Mercy Hospital Kansas City, Missouri, United States, 64108 Less <<
NCT03776058 Primary Hyperparathyroidism Phase 2 Completed - -
NCT02549391 Secondary Hyperparathyroidism Phase 2 Phase 3 Completed - Japan ... More >> For additional information regarding investigative sites for this trial, contact Kyowa Hakko Kirin Tokyo, Japan Less <<
NCT02138838 - Terminated(Sponsor decision) - -
NCT00345839 - Completed - -
NCT01143987 Hyperparathyroidism ... More >> Arterial Stiffness Less << Phase 4 Completed - Hong Kong ... More >> Prince of Wales Hospital, Chinese University of Hong Kong Shatin, New Territories, Hong Kong, SAR Less <<
NCT00431496 Anemia Second... More >>ary Hyperparathyroidism Less << Phase 4 Completed - -
NCT01011114 Hypophosphatemia ... More >> Renal Transplant Less << Not Applicable Unknown - United States, New York ... More >> Montefiore Medical Center Recruiting Bronx, New York, United States, 10467 Principal Investigator: Maria Coco, MD,MS Less <<
NCT00952094 Healthy Phase 1 Completed - Korea, Republic of ... More >> Seoul National University Hospital Clinical Trial Center Seoul, Korea, Republic of Less <<
NCT00431496 - Completed - -
NCT02338934 Secondary Hyperparathyroidism Phase 4 Unknown January 2017 Malaysia ... More >> Clinical Research Centre, Penang Hospital George Town, Penang, Malaysia, 10990 Penang Hospital Not yet recruiting George Town, Penang, Malaysia, 10990 Contact: Ong Loke Meng, FRCS    00 604 2225333 ext 767    onglm@crc.gov.my Less <<
NCT03123406 Hyperparathyroidism; Secondary... More >>, Renal Less << PHASE4 COMPLETED 2019-09-06 Nanjing Jinling Hospital, Nanj... More >>ing, Jiangsu, 210002, China Less <<
NCT02417389 Hyperparathyroidism, Primary ... More >> Osteoporosis Less << Phase 4 Completed - Italy ... More >> Istituto Auxologico Italiano IRCCS Milano, Italy, 20145 Less <<
NCT01439867 - Terminated(Sponsor decision) - -
NCT01054079 Adenocarcinoma of the Prostate... More >> Recurrent Prostate Cancer Less << Phase 2 Completed - United States, North Carolina ... More >> Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157 Less <<
NCT03299244 Secondary Hyperparathyroidism ... More >> Chronic Kidney Disease Less << Phase 3 Recruiting November 26, 2019 -
NCT01439867 Chronic Kidney Disease ... More >> Hyperparathyroidism, Secondary Less << Phase 2 Terminated(Sponsor decision) - -
NCT02341417 Secondary Hyperparathyroidism,... More >> Chronic Kidney Disease Less << Phase 3 Completed - -
NCT01479088 Secondary Hyperparathyroidism PHASE2|PHASE3 UNKNOWN 2025-12-13 U.O. Nefrologia e Dialisi- Osp... More >>edale Giovanni XXIII, Bari, 70100, Italy|U.O. Nefrologia e Dialisi - Istituto di Ricovero e Cura a Carattere Scientifico Giannina Gaslini, Genoa, 16147, Italy|U.O. Nefrologia e Dialisi Pediatrica - Clinica De Marchi, Milan, 20100, Italy|U.O. Nefrologia e Dialisi - Ospedale Santobono, Naples, 80100, Italy|U.O. Nefrologia e Dialisi - Ospedale Bambino Gesù, Rome, 00100, Italy Less <<
NCT01290029 - Completed - -
NCT01290029 Chronic Kidney Disease ... More >> Hyperparathyroidism, Secondary Secondary Hyperparathyroidism Less << Phase 1 Completed - United States, California ... More >> Research Site Los Angeles, California, United States, 90095 Research Site San Francisco, California, United States, 94143 United States, Kentucky Research Site Louisville, Kentucky, United States, 40202 United States, Missouri Research Site Kansas City, Missouri, United States, 64108 Germany Research Site Heidelberg, Germany, 69120 United Kingdom Research Site Bristol, United Kingdom, BS2 8BJ Research Site Glasgow, United Kingdom, G3 8SJ Research Site Leeds, United Kingdom, LS1 3EX Research Site Manchester, United Kingdom, M13 9WL Research Site Nottingham, United Kingdom, NG7 2UH Less <<
NCT01054079 - Completed - -
NCT02341417 - Completed - -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.54mL

0.51mL

0.25mL

12.69mL

2.54mL

1.27mL

25.39mL

5.08mL

2.54mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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