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Chemical Structure| 32986-56-4 Chemical Structure| 32986-56-4
Chemical Structure| 32986-56-4

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Tobramycin

CAS No.: 32986-56-4

Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius.

Synonyms: Nebramycin Factor 6;Deoxykanamycin B;NSC 180514

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Cat. No.: A976001 Purity: ≥900ug/mg

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Product Details of [ 32986-56-4 ]

CAS No. :32986-56-4
Formula : C18H37N5O9
M.W : 467.51
SMILES Code : O[C@@H]([C@@H]1O[C@@]([C@@H](C[C@@H]2O)N)([H])O[C@@H]2CN)[C@H]([C@@H](C[C@@H]1N)N)O[C@@]([C@@H]([C@@H](N)[C@@H]3O)O)([H])O[C@@H]3CO
Synonyms :
Nebramycin Factor 6;Deoxykanamycin B;NSC 180514
MDL No. :MFCD00077885
InChI Key :NLVFBUXFDBBNBW-PBSUHMDJSA-N
Pubchem ID :36294

Safety of [ 32986-56-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis [ 32986-56-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 32986-56-4 ]

[ 32986-56-4 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 32986-56-4 ]
  • [ 35237-37-7 ]
  • 5C12H25NO2*C18H37N5O9 [ No CAS ]
YieldReaction ConditionsOperation in experiment
In ethanol; water; at 20 - 40℃; General procedure: 1:1 Molar Ratio. TOB-LAA10-11, TOB-LAA12-11, and TOB-LAA14-11, equimolar ion pairs between TOB and the LAA bearing a side alkyl chain of 7, 9, or 11 carbon atoms, respectively (Fig. 1) were prepared by co-evaporation of a co-solution of the two components. TOB base (0.3 mmol) was dissolved in water, while the appropriate LAA (0.3 mmol) was dissolved under magnetic stirring in absolute ethanol. The two solutions were mixed for about 4 h at 40 C and then at overnight room temperature. Ethanol and part of the water were removed under high vacuum at an external temperature of 40 C. Residual water was finally removed by freeze-drying (Edward Modulyo). The resulting fluffy, white powders were stored in tight closed glass vials at 4 +/- 1 C until use.1:3 Molar Ratio. TOB-LAA10-13 and TOB-LAA12-13 were obtained in a similar manner, starting from 0.3 mmol TOB and 0.9 mmol of the chosen LAA.1:5 Molar Ratio. TOB-LAA10-15 and TOB-LAA12-15 were obtained in a similar manner, starting from 0.2 mmol TOB and 1 mmol of the chosen LAA.
  • 2
  • [ 32986-56-4 ]
  • [ 35237-37-7 ]
  • [ 1300713-55-6 ]
YieldReaction ConditionsOperation in experiment
In ethanol; water; at 20 - 40℃; General procedure: 1:1 Molar Ratio. TOB-LAA10-11, TOB-LAA12-11, and TOB-LAA14-11, equimolar ion pairs between TOB and the LAA bearing a side alkyl chain of 7, 9, or 11 carbon atoms, respectively (Fig. 1) were prepared by co-evaporation of a co-solution of the two components. TOB base (0.3 mmol) was dissolved in water, while the appropriate LAA (0.3 mmol) was dissolved under magnetic stirring in absolute ethanol. The two solutions were mixed for about 4 h at 40 C and then at overnight room temperature. Ethanol and part of the water were removed under high vacuum at an external temperature of 40 C. Residual water was finally removed by freeze-drying (Edward Modulyo). The resulting fluffy, white powders were stored in tight closed glass vials at 4 +/- 1 C until use.1:3 Molar Ratio. TOB-LAA10-13 and TOB-LAA12-13 were obtained in a similar manner, starting from 0.3 mmol TOB and 0.9 mmol of the chosen LAA.1:5 Molar Ratio. TOB-LAA10-15 and TOB-LAA12-15 were obtained in a similar manner, starting from 0.2 mmol TOB and 1 mmol of the chosen LAA.
  • 3
  • [ 32986-56-4 ]
  • [ 35237-37-7 ]
  • 3C12H25NO2*C18H37N5O9 [ No CAS ]
YieldReaction ConditionsOperation in experiment
In ethanol; water; at 20 - 40℃; General procedure: 1:1 Molar Ratio. TOB-LAA10-11, TOB-LAA12-11, and TOB-LAA14-11, equimolar ion pairs between TOB and the LAA bearing a side alkyl chain of 7, 9, or 11 carbon atoms, respectively (Fig. 1) were prepared by co-evaporation of a co-solution of the two components. TOB base (0.3 mmol) was dissolved in water, while the appropriate LAA (0.3 mmol) was dissolved under magnetic stirring in absolute ethanol. The two solutions were mixed for about 4 h at 40 C and then at overnight room temperature. Ethanol and part of the water were removed under high vacuum at an external temperature of 40 C. Residual water was finally removed by freeze-drying (Edward Modulyo). The resulting fluffy, white powders were stored in tight closed glass vials at 4 +/- 1 C until use.1:3 Molar Ratio. TOB-LAA10-13 and TOB-LAA12-13 were obtained in a similar manner, starting from 0.3 mmol TOB and 0.9 mmol of the chosen LAA.1:5 Molar Ratio. TOB-LAA10-15 and TOB-LAA12-15 were obtained in a similar manner, starting from 0.2 mmol TOB and 1 mmol of the chosen LAA.
  • 4
  • [ 32986-56-4 ]
  • [ 81-13-0 ]
  • tobramycin penta-dexpanthenol [ No CAS ]
YieldReaction ConditionsOperation in experiment
In methanol; Example 7 Preparation of Tobramycin Penta-Dexpanthenol (0079) 2.2 g dexpanthenol were dissolved in 75 mL methanol and then 1 g of tobramycin (see Example 5 as the free base) was added to the solution. Subsequently, the solution was evaporated to dryness
 

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