There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
*Storage: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C.
*Shipping:
Tunicamycin is a homologous nucleoside antibiotic mixture that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase (GPT), causing ER stress by accumulating unfolded proteins in the endoplasmic reticulum. It induces G1 phase cell cycle arrest, inhibits gram-positive bacteria, yeasts, fungi, and viruses, and has anticancer activity. Additionally, tunicamycin increases exosome release in cervical cancer cells.
Synonyms: Tunicamycin Mixture
4.5
*For Research Use Only !
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 11089-65-9 |
Formula : | C37H60N4O16 |
M.W : | 816.89 |
SMILES Code : | NONE |
Synonyms : |
Tunicamycin Mixture
|
MDL No. : | MFCD00065709 |
GHS Pictogram: | ![]() |
Signal Word: | Danger |
Hazard Statements: | H300 |
Precautionary Statements: | P264-P301+P310 |
Class: | 6.1 |
UN#: | 3462 |
Packing Group: | Ⅱ |
In Vitro:
Cell Line
| Concentration | Treated Time | Description | Reference |
HEK-293T cells | 1 µM | 24 h | To detect abnormal N-glycosylation, it was found that inhibition of N-glycosylation stabilized the localization of Halo protein in the ER | PMC7810369 |
A549 cells | 1 µM | 24 h | Induction of Halo1N fluorescence by inhibition of N-glycosylation validated Halo1N as a reliable indicator of abnormal N-glycosylation | PMC7810369 |
MC38 epithelial cells | 1μM | 4 h | Induce ER stress and promote AIEC MSL1 replication | PMC9805753 |
SH-SY5Y neuroblastoma cells | 1 μg/ml | 48 h | To investigate the effect of Tunicamycin on ER stress-induced cell death in SH-SY5Y cells and found that flurbiprofen significantly inhibited this cell death. | PMC3958308 |
NIT-1 pancreatic β-cells | 0.05 μg/mL | 24 h | To investigate the effect of Tunicamycin on the viability of NIT-1 pancreatic β-cells, the results showed that Tunicamycin significantly decreased cell viability in a dose-dependent manner. | PMC8229938 |
HepG2 cells | 12 μM | 6 h | Induction of ER stress, suppression of CYP7A1 expression, and increased expression of ABCB11 and ABCC3 | PMC5331781 |
CHO cells | 500nM | 24 h | To validate the function of the NLG reporter, showing increased bioluminescence in CHO cells after Tunicamycin treatment | PMC3413408 |
293T cells | 500nM | To validate the design of the NLG reporter, showing altered glycosylation status of Luc protein in 293T cells after Tunicamycin treatment | PMC3413408 | |
Huh7shCON and Huh7shXBP1 cells | 5 μg/ml | 6 h | To induce ER stress and investigate the role of XBP1 in ER stress-induced FGF21 expression. Results showed that despite XBP1 knockdown, Huh7shXBP1 cells could still induce FGF21 expression normally under ER stress. | PMC5699917 |
MEF cells | 3 μg/ml | 48 h | To investigate the change of EVA1A expression under ER stress, the results showed a significant increase of EVA1A protein level in the wild type (WT) cells, but not in Chop knockout cells upon tunicamycin treatment. | PMC9887066 |
HEK293 cells | 3 μg/ml | 48 h | To investigate the interaction between EVA1A and MCL1, the results showed a significant interaction of EVA1A with MCL1 in cells after tunicamycin treatment. | PMC9887066 |
LSK cells | 3 μg/ml | 36 h | To investigate the change of EVA1A expression under ER stress, the results showed an enhanced EVA1A mRNA level in the LSK cells from the mice treated with tunicamycin. | PMC9887066 |
Caco-2 cells | 2 µg/ml | 5 or 7 h | To study the effect of ER stress on HMGCS2 expression, results showed that TM significantly decreased HMGCS2 transcription | PMC10348483 |
HT29 cells | 2 µg/ml | 5 or 7 h | To study the effect of ER stress on HMGCS2 expression, results showed that TM significantly decreased HMGCS2 transcription | PMC10348483 |
In Vivo:
Species
| Animal Model
| Administration | Dosage | Frequency | Description | Reference |
C57BL/6J mice | ER stress model | Intraperitoneal injection | 0.5 mg/kg (acute), 0.1 mg/kg (chronic) | Single injection (acute), daily injections for 5 days (chronic) | Induction of ER stress, suppression of Cyp7a1 expression, increased expression of Abcb11 and Abcc3, and reduced hepatic bile acid content | PMC5331781 |
Nude mice | D54 glioma xenograft model | Intraperitoneal injection | 0.75mg/kg | Single dose, lasting several days | To evaluate the effect of Tunicamycin on NLG inhibition in vivo, showing that Tunicamycin significantly reduces EGFR and Met protein levels in D54 tumors and enhances tumor radiosensitivity | PMC3413408 |
mice | hepatocyte-specific Xbp1 knockout mice (Xbp1LKO) | intraperitoneal injection | 0.5 mg/kg | single injection, sacrificed 6 hours post-injection | To investigate the induction of FGF21 in hepatocyte-specific Xbp1 knockout mice under pharmacologic ER stress. Results showed that Xbp1LKO mice could still induce FGF21 expression normally under ER stress, indicating that Xbp1 is not required for ER stress-induced FGF21 expression. | PMC5699917 |
mice | WT and Eva1aF/F,Vav-Cre mice | intraperitoneal injection | 0.5 mg/kg | every 3 days for 7 days | To investigate the change of EVA1A expression under ER stress and its effect on HSPCs, the results showed that Eva1a deficient mice had more LSK, LT-HSC, ST-HSC, MPP3, MPP4, CMP, and GMP cells in BM than that in WT mice after tunicamycin treatment. | PMC9887066 |
C57BL/6 mice | Wild type and Xbp1DIEC mice | Intraperitoneal injection | 10 µg/gr | Single injection, sacrificed at 24 hours | To study the effect of ER stress on HMGCS2 expression, results showed that TM significantly decreased HMGCS2 expression | PMC10348483 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT01754441 | - | Unknown | December 2017 | United States, Delaware ... More >> Alfred I. duPont Hospital for Children Wilmington, Delaware, United States, 19803 United States, Florida Nemours Children's Specialty Care, Jacksonville Jacksonville, Florida, United States, 32207 Nemours Children's Hospital Orlando, Florida, United States, 32827 Less << |
Tags: 11089-65-9 synthesis path| 11089-65-9 SDS| 11089-65-9 COA| 11089-65-9 purity| 11089-65-9 application| 11089-65-9 NMR| 11089-65-9 COA| 11089-65-9 structure
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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