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Chemical Structure| 166168-16-7 Chemical Structure| 166168-16-7
Chemical Structure| 166168-16-7

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tert-Butyl ((trans-4-(aminomethyl)cyclohexyl)methyl)carbamate

CAS No.: 166168-16-7

4.5 *For Research Use Only !

Cat. No.: A838743 Purity: 98%

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Product Details of [ 166168-16-7 ]

CAS No. :166168-16-7
Formula : C13H26N2O2
M.W : 242.36
SMILES Code : O=C(OC(C)(C)C)NC[C@H]1CC[C@H](CN)CC1
MDL No. :MFCD04112680

Safety of [ 166168-16-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis [ 166168-16-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 166168-16-7 ]

[ 166168-16-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5467-57-2 ]
  • [ 166168-16-7 ]
  • [ 1165797-46-5 ]
YieldReaction ConditionsOperation in experiment
57% With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 2-methyltetrahydrofuran; water; at 20℃; for 96h;Inert atmosphere; N-Methyl morpholine (5.9 mL, 54 mmol) and 4 (6.7 g, 28 mmol) were added to a solution of <strong>[5467-57-2]2-chloroquinoline-4-carboxylic acid</strong> (5.6 g, 27 mmol) in a mixture of 2-MeTHF (50 mL) and H2O (34 mL) at rt. An aqueous solution (9 mL) of HOBt (20percent w/w) and N-methyl morpholine (15percent w/w) was added to the stirred solution followed by the addition of EDC (6.7 g, 35 mmol). The reaction mixture was stirred vigorously at rt for 4 days. The mixture was filtered and the collected solid was washed with water containing 10percent MeOH to leave the title compound as an off-white solid (6.6 g, 57percent): 1H NMR (400 MHz, DMSO-d6) delta 8.81 (t, J = 5.7 Hz, 1H), 8.07 (d, J = 8.4 Hz, 1H), 7.99 (d, J = 8.4 Hz, 1H), 7.89-7.81 (m, 1H), 7.73-7.66 (m, 1H), 7.59 (s, 1H), 6.77 (t, J = 5.6 Hz, 1H), 3.21-3.12 (m, 2H), 2.79-2.72 (m, 2H), 1.83-1.74 (m, 2H), 1.72-1.64 (m, 2H), 1.56-1.43 (m, 1H), 1.35 (s, 9H), 1.33-1.24 (m, 1H), 0.90-0.75 (m, 4H); HRMS (ESI) m/z calcd for C23H31ClN3O3 [M+H]+ 432.2054; found 432.2072.
 

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