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Chemical Structure| 741713-40-6 Chemical Structure| 741713-40-6
Chemical Structure| 741713-40-6

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R547

CAS No.: 741713-40-6

R547 is a potent ATP-competitive CDK inhibitor with Ki values of 2 nM, 3 nM, and 1 nM for CDK1/cyclin B, CDK2/cyclin E, and CDK4/cyclin D1, respectively, exhibiting efficient cell cycle inhibition.

Synonyms: Ro 4584820

4.5 *For Research Use Only !

Cat. No.: A454118 Purity: 98%

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Product Details of [ R547 ]

CAS No. :741713-40-6
Formula : C18H21F2N5O4S
M.W : 441.45
SMILES Code : O=C(C1=CN=C(NC2CCN(S(=O)(C)=O)CC2)N=C1N)C3=C(OC)C=CC(F)=C3F
Synonyms :
Ro 4584820
MDL No. :MFCD09970629

Safety of [ R547 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of [ R547 ]

PI3K-AKT
Hedgehog

ALK Isoform Comparison

Name Cdc CDK1 CDK19 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CLK Purity
PHA-767491 HCl ++++

Cdc7, IC50: 10 nM

+

CDK1, IC50: 250 nM

+

CDK2, IC50: 240 nM

+

CDK5, IC50: 460 nM

+++

CDK9, IC50: 34 nM

99%
Purvalanol A ++++

Cdc2/CyclinB, IC50: 4 nM

+++

CDK2/CyclinA, IC50: 70 nM

CDK2/CyclinE, IC50: 35 nM

+

CDK4/CyclinD1, IC50: 850 nM

98%
XL413 HCl ++++

Cdc7, IC50: 3.4 nM

98%
(R)-Roscovitine +

Cdc2/CyclinB, IC50: 0.65 μM

+

CDK2/CyclinA, IC50: 0.7 μM

CDK2/CyclinE, IC50: 0.7 μM

++

CDK5/p35, IC50: 0.16 μM

98%
SU9516 +++

CDK1, IC50: 40 nM

+++

CDK2, IC50: 22 nM

++

CDK4, IC50: 200 nM

99% (HPLC)
RO-3306 +++

CDK1, Ki: 20 nM

98%
Kenpaullone +

CDK1/CyclinB, IC50: 0.4μM

+

CDK2/CyclinA, IC50: 0.68μM

CDK2/CyclinE, IC50: 7.5μM

+

CDK5/p35, IC50: 0.85μM

98%
R547 ++++

CDK1/CyclinB, Ki: 2 nM

++++

CDK2/CyclinE, Ki: 3 nM

++++

CDK4/CyclinD1, Ki: 1 nM

98%
Dinaciclib ++++

CDK1, IC50: 3 nM

++++

CDK2, IC50: 1 nM

++++

CDK5, IC50: 1 nM

++++

CDK9, IC50: 4 nM

98%
BMS-265246 ++++

CDK1/CyclinB, IC50: 6 nM

++++

CDK2/CyclinE, IC50: 9 nM

+

CDK4/CyclinD, IC50: 230 nM

98+%
NU6027 +

CDK1, Ki: 2.5 μM

+

CDK2, Ki: 1.3 μM

98%
AZD-5438 +++

CDK1, IC50: 16 nM

++++

CDK2, IC50: 6 nM

+++

CDK9, IC50: 20 nM

99%
LDC000067 +

CDK2, IC50: 2.441 μM

++

CDK9, IC50: 44 nM

98%
SCH900776 ++

CDK2, IC50: 0.16 μM

99%
AUZ 454 ++++

CDK2(A144C), Kd: 9.7 nM

CDK2(C118L), Kd: 18.6 nM

98+%
A-674563 HCl ++

CDK2, Ki: 46 nM

99%
AT7519 ++

CDK1/CyclinB, IC50: 210 nM

++

CDK2/CyclinA, IC50: 47 nM

+

CDK3/CyclinE, IC50: 360 nM

++

CDK4/CyclinD1, IC50: 100 nM

+++

CDK5/p35, IC50: 13 nM

++

CDK6/CyclinD3, IC50: 170 nM

++++

CDK9/CyclinT, IC50: <10 nM

98+%
JNJ-7706621 ++++

CDK1/CyclinB, IC50: 9 nM

++++

CDK2/CyclinA, IC50: 4 nM

CDK2/CyclinE, IC50: 3 nM

++

CDK3/CyclinE, IC50: 58 nM

+

CDK4/CyclinD1, IC50: 253 nM

++

CDK6/CyclinD1, IC50: 175 nM

99%
Narazaciclib ++++

CDK4/CyclinD1, IC50: 3.87 nM

++++

CDK6/CyclinD1, IC50: 9.82 nM

98%
Palbociclib ++++

CDK4/CyclinD3, IC50: 9 nM

CDK4/CyclinD1, IC50: 11 nM

+++

CDK6/CyclinD2, IC50: 15 nM

99%
Abemaciclib ++++

CDK4, IC50: 2 nM

++++

CDK6, IC50: 10 nM

99%
Ribociclib ++++

CDK4, IC50: 10 nM

+++

CDK6, IC50: 39 nM

98%
Palbociclib isethionate ++++

CDK4/CyclinD3, IC50: 9 nM

CDK4/CyclinD1, IC50: 11 nM

+++

CDK6/CyclinD2, IC50: 15 nM

98%
BS-181 HCl +++

CDK7, IC50: 21 nM

98%
PHA-793887 ++

CDK1/CyclinB, IC50: 60 nM

++++

CDK2/CyclinA, IC50: 8 nM

CDK2/CyclinE, IC50: 8 nM

++

CDK4/CyclinD1, IC50: 62 nM

++++

CDK5/p25, IC50: 5 nM

++++

CDK7/CyclinH, IC50: 10 nM

++

CDK9/CyclinT1, IC50: 138 nM

98%
Riviciclib HCl ++

CDK1/CyclinB, IC50: 79 nM

+

CDK2/CyclinA, IC50: 224 nM

CDK2/CyclinE, IC50: 2.54 μM

++

CDK4/CyclinD1, IC50: 63 nM

+

CDK6/CyclinD3, IC50: 396 nM

+

CDK7/CyclinH, IC50: 2.87 μM

+++

CDK9/CyclinT1, IC50: 20 nM

98%
Flavopiridol +++

CDK1, IC50: 40 nM

+++

CDK2, IC50: 40 nM

+++

CDK4, IC50: 40 nM

+++

CDK6, IC50: 40 nM

+

CDK7, IC50: 300 nM

+++

CDK9, IC50: 20 nM

98%
Milciclib +

CDK1/CyclinB, IC50: 398 nM

++

CDK2/CyclinA, IC50: 45 nM

CDK2/CyclinE, IC50: 363 nM

++

CDK4/CyclinD1, IC50: 160 nM

+

CDK5/p35, IC50: 265 nM

++

CDK7/CyclinH, IC50: 150 nM

98+%
SNS-032 +++

CDK2/CyclinA, IC50: 38 nM

CDK2/CyclinE, IC50: 48 nM

+

CDK5/p35, IC50: 340 nM

++

CDK7/CyclinH, IC50: 62 nM

++++

CDK9/CyclinT, IC50: 4 nM

99%
LY2857785 +

CDK7, IC50: 0.246 μM

+++

CDK8, IC50: 0.016 μM

+++

CDK9, IC50: 0.011 μM

98%
(E/Z)-THZ1 2HCl ++++

CDK7, IC50: 3.2 nM

98%
LDC4297 ++++

CDK7, IC50: 0.13 nM

98+%
MSC2530818 ++++

CDK8, IC50: 2.6 nM

99%
Wogonin 98%
ML167 ++

Dyrk1B , IC50: 1648 nM

CLK4, IC50: 136 nM

98%
(E/Z)-TG003 +++

mCLK1, IC50: 200 nM

mCLK4, IC50: 15 nM

99+%
Name GSK-3 GSK-3α GSK-3β Purity
AZD2858 +

GSK-3, IC50: 68 nM

99%
Bikinin 98%
GSK 3 Inhibitor IX ++++

GSK-3, IC50: 5 nM

98%
TDZD-8 +

GSK-3β, IC50: 2 μM

98%
AZD1080 +++

GSK-3α, IC50: 6.9 nM

++

GSK-3β, IC50: 31 nM

98+%
BIO-acetoxime +++

GSK-3α, IC50: 10 nM

+++

GSK-3β, IC50: 10 nM

95%
SB-216763 ++

GSK-3α, IC50: 34.3 nM

++

GSK-3β, IC50: ~34.3 nM

98%
Indirubin +

GSK-3β, IC50: 0.6 μM

98%
SB 415286 +

GSK-3α, IC50: 78 nM

+

GSK-3β, IC50: ~78 nM

99%
IM-12 ++

GSK-3β, IC50: 53 nM

98%
CHIR-98014 ++++

GSK-3α, IC50: 0.65 nM

++++

GSK-3β, IC50: 0.58 nM

98%
LY2090314 ++++

GSK-3α, IC50: 1.5 nM

++++

GSK-3β, IC50: 0.9 nM

99%
CHIR 99021 +++

GSK-3α, IC50: 10 nM

++++

GSK-3β, IC50: 6.7 nM

98%
TWS119 ++

GSK-3β, IC50: 30 nM

99%
1-Azakenpaullone +++

GSK-3β, IC50: 18 nM

98%
AR-A014418 ++

GSK-3β, Ki: 38 nM

99%
Tideglusib +

GSK-3β, IC50: 60 nM

98%

Biological Activity

Target
  • CDK4

    CDK4/CyclinD1, Ki:1 nM

  • CDK2

    CDK2/CyclinE, Ki:3 nM

  • CDK1

    CDK1/CyclinB, Ki:2 nM

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.27mL

0.45mL

0.23mL

11.33mL

2.27mL

1.13mL

22.65mL

4.53mL

2.27mL

References

 

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