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Chemical Structure| 478336-92-4 Chemical Structure| 478336-92-4
Chemical Structure| 478336-92-4

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ISO-1

CAS No.: 478336-92-4

ISO-1 is an inhibitor of macrophage migration inhibitory factor (MIF) with an IC50 of 7 μM. By suppressing the keto-enol tautomerase activity of MIF, it blocks signaling pathways related to inflammation and cancer, exhibiting potential anti-inflammatory and anticancer effects.

Synonyms: MIF Antagonist;Macrophage Migration Inhibitory Factor

4.5 *For Research Use Only !

Cat. No.: A128540 Purity: 98%

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Product Details of [ ISO-1 ]

CAS No. :478336-92-4
Formula : C12H13NO4
M.W : 235.24
SMILES Code : O=C(OC)CC1CC(C2=CC=C(O)C=C2)=NO1
Synonyms :
MIF Antagonist;Macrophage Migration Inhibitory Factor
MDL No. :MFCD22376813
InChI Key :AIXMJTYHQHQJLU-UHFFFAOYSA-N
Pubchem ID :4633677

Safety of [ ISO-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P280-P305+P351+P338

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02204202 - Recruiting May 2019 United States, Missouri ... More >> Washington University School of Medicine / Barnes-Jewish Hospital Recruiting Saint Louis, Missouri, United States, 63110 Contact: Delphine L Chen, MD    314-362-7029    chend@mir.wustl.edu    Principal Investigator: Delphine L Chen, MD Less <<
NCT03057743 - Recruiting April 5, 2020 United States, Pennsylvania ... More >> Abramson Cancer Center of the University of Pennsylvania Recruiting Philadelphia, Pennsylvania, United States, 19004 Contact: Elizabeth McDonald, MD, Ph.D    855-216-0098    PennCancerTrials@emergingmed.com Less <<
NCT00968656 Breast Cancer ... More >> Head and Neck Cancer Diffuse Large B-cell Lymphoma Less << Phase 1 Completed - United States, Missouri ... More >> Washington University / Barnes Jewish Hospital Saint Louis, Missouri, United States, 63110 Less <<
NCT02284919 Breast Cancer ... More >> Breast Neoplasm Less << Phase 1 Active, not recruiting November 2019 United States, Pennsylvania ... More >> University of Pennsylvania Hospital Philadelphia, Pennsylvania, United States, 19104 Less <<

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Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.25mL

0.85mL

0.43mL

21.26mL

4.25mL

2.13mL

42.51mL

8.50mL

4.25mL

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