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Reparixin is a non-competitive allosteric inhibitor of CXCR1 and CXCR2 activation, with IC50s of 1 nM and 100 nM, respectively.
Synonyms: Repertaxin;DF 1681Y
4.5
*For Research Use Only !
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 266359-83-5 |
Formula : | C14H21NO3S |
M.W : | 283.39 |
SMILES Code : | O=C(NS(=O)(C)=O)[C@H](C)C1=CC=C(CC(C)C)C=C1 |
Synonyms : |
Repertaxin;DF 1681Y
|
MDL No. : | MFCD18633292 |
InChI Key : | KQDRVXQXKZXMHP-LLVKDONJSA-N |
Pubchem ID : | 9838712 |
GHS Pictogram: | ![]() |
Signal Word: | Warning |
Hazard Statements: | H302 |
Precautionary Statements: | P280-P305+P351+P338 |
Target |
|
In Vitro:
Cell Line
| Concentration | Treated Time | Description | Reference |
Mouse osteoclasts | 1 μg/mL | 4 days | To investigate the effect of ACPA on CXCL1 release from mouse osteoclasts, results showed that ACPA significantly increased CXCL1 release. | PMC4819624 |
mouse hepatocytes | 20 ng/ml | 3 hours | To evaluate whether TNF α upregulates CXCR1 expression, results showed that hepatocytes from CXCR2-/- mice had marked expression of CXCR1 after 24 hours of recovery from TNF α stimulation. | PMC3058860 |
mouse hepatocytes | 0-10,000 ng/ml | 24 hours | To evaluate the effects of CXCR1 signaling on hepatocyte cell death and proliferation, results showed that IL-8 stimulated marked hepatocyte proliferation at doses as low as 10 ng/ml and induced modest toxicity at the highest dose (10,000 ng/ml). | PMC3058860 |
Neutrophils | 10^-6 M | 20 minutes | Inhibited neutrophil chemotaxis induced by the ILT luminal layer by 50% | PMC2682614 |
SUM159 cells | 100 nM | 3 days | A 5-fold reduction in the proportion of ALDEFLUOR+ cells was observed, indicating that Reparixin selectively reduced the breast cancer stem cell (CSC) population. | PMC2810075 |
SUM159 cells | 100 nM | 5 days | A massive decrease in cell viability was observed, with only 3% of cells remaining viable, indicating that Reparixin induced massive apoptosis. | PMC2810075 |
HCC1954 cells | 100 nM | 5 days | A significant decrease in cell viability was observed, indicating that Reparixin had a similar cytotoxic effect on HCC1954 cells. | PMC2810075 |
human PMN | 1 µM | 4 hours | To evaluate the effect of Reparixin on CXCL8-induced gene expression, results showed that Reparixin inhibited CXCL8-induced gene expression. | PMC511013 |
L1.2 transfectants | 1 µM | To evaluate the effect of Reparixin on CXCL8-induced cell migration, results showed that Reparixin inhibited CXCL8-induced cell migration. | PMC511013 | |
Human donor neutrophils | 250 mg/ml | Reparixin inhibited NET formation induced by septic patient plasma, reducing NET formation and fibrin deposition in the lungs | PMC8792833 |
In Vivo:
Species
| Animal Model
| Administration | Dosage | Frequency | Description | Reference |
Mice | Balb/c mice | Subcutaneous injection | 15 mg/kg | every 3 days for 14 consecutive days | Reparixin completely reversed the bone loss induced by ACPA. | PMC4819614 |
Mice | ACPA-induced pain model | Subcutaneous injection | 10 mg/kg | Daily for 14 consecutive days | To investigate the effect of Reparixin on ACPA-induced pain-like behavior, results showed that Reparixin partially reversed ACPA-induced mechanical hypersensitivity. | PMC4819624 |
mice | hepatic ischemia/reperfusion injury model | intraperitoneal injection | 30 mg/kg/day | Twice daily for 6 days | To evaluate the role of CXCR1 in liver recovery after hepatic ischemia/reperfusion injury, results showed that Reparixin treatment delayed liver recovery and increased hepatocellular necrosis. | PMC3058860 |
Mice | SPARC-null mouse model | Intraperitoneal injection | 30 mg/kg/day | Twice daily for 6 days | Chronic inhibition with reparixin alleviated low back pain behaviors and attenuated disc inflammation in SPARC-null mice. | PMC6558025 |
Mice | Prostate tumor model | Subcutaneous injection | 30 mg/kg | started 24 hours after reperfusion, every 12 hours | Improve the antitumor efficacy of the TRT→ADT combination by blocking CXCR2 | PMC11043705 |
NOD/SCID mice | human breast cancer xenografts | subcutaneous injection | 20 or 30 mg/kg | 3 times per week for 8 weeks | Reparixin treatment alone or in combination with docetaxel significantly reduced the ALDEFLUOR+ population and retarded tumor growth, reducing metastasis. | PMC2810075 |
mice | Cecal Ligation and Puncture (CLP) model | subcutaneous injection | 5 mg/kg | Thrice a week for 3 weeks | To evaluate the inhibitory effect of Reparixin on PMN recruitment in the CLP model, results showed that Reparixin significantly reduced PMN recruitment. | PMC511013 |
C57BL/6 male mice | Sepsis model induced by caecal ligation and puncture (CLP) or intraperitoneal injection of Escherichia coli K12 strain | Subcutaneous injection | 15 mg/kg | twice daily for 28 days | Reparixin reduced NET formation, multi-organ injury, and mortality in septic mice without impairing bacterial clearance | PMC8792833 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT01220856 | Pancreatic Islet Transplantati... More >>on in Type 1 Diabetes Mellitus Less << | PHASE2 | COMPLETED | 2013-04-30 | University Hospital Carl Gusta... More >>v Carus Dresden, Dresden, 01307, Germany|Ospedale San Raffaele, Milan, 20132, Italy Less << |
NCT01861054 | Breast Cancer | PHASE2 | TERMINATED | 2016-03-01 | Indiana University Simon Cance... More >>r Center, Indianapolis, Indiana, 46202-5289, United States|University of Kansas Cancer Center, 4350 Shawnee Mission Pkwy, Suite 1500, Mailstop 6004, Fairway, Kansas, 66205, United States|The Cancer Institute of New Jersey, New Brunswick, New Jersey, 08903, United States|Montefiore Medical Center, MMC Medical Park at Eastchester, Bronx, New York, 10461, United States|Weill Cornell Medical College, New York, New York, 10065, United States|Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111, United States|Magee-Womens Hospital, Pittsburgh, Pennsylvania, 15213, United States|Sara Cannon Research Institute, Nashville, Tennessee, 37203, United States|The Methodist Hospital Research Institute, Houston, Texas, 77030, United States Less << |
Tags: 266359-83-5 synthesis path| 266359-83-5 SDS| 266359-83-5 COA| 266359-83-5 purity| 266359-83-5 application| 266359-83-5 NMR| 266359-83-5 COA| 266359-83-5 structure
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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