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Chemical Structure| 24584-09-6 Chemical Structure| 24584-09-6
Chemical Structure| 24584-09-6

*Storage: Inert atmosphere,Room Temperature.

Dexrazoxane

CAS No.: 24584-09-6

Dexrazoxane is both an antimitotic agent with immunosuppressive properties and a cardioprotective agent.

Synonyms: ICRF-187;ADR-529;Zinecard. Foreign brand names: Cardioxane Savene.

4.5 *For Research Use Only !

Cat. No.: A170417 Purity: 98%

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Product Details of [ Dexrazoxane ]

CAS No. :24584-09-6
Formula : C11H16N4O4
M.W : 268.27
SMILES Code : C[C@@H](CN1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1
Synonyms :
ICRF-187;ADR-529;Zinecard. Foreign brand names: Cardioxane Savene.
MDL No. :MFCD00866449
InChI Key :BMKDZUISNHGIBY-ZETCQYMHSA-N
Pubchem ID :71384

Safety of [ Dexrazoxane ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Biological Activity

Target
  • Topo II

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02786719 Neuroblastoma Not Applicable Recruiting June 2019 United States, California ... More >> Rady Children's Hospital Recruiting San Diego, California, United States, 92123 Contact: Laura Conner    858-966-5983    LConner@rchsd.org    Principal Investigator: Peter Zage, MD          United States, Texas Texas Children's Hospital Recruiting Houston, Texas, United States, 77030 Contact: Sarah Whittle, MD, BA    832-822-4242    sbwhittl@txch.org Less <<
NCT00077285 Sarcoma Phase 2 Active, not recruiting October 2019 United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Less <<
NCT00400946 Drug/Agent Toxicity by Tissue/... More >>Organ Leukemia Less << Phase 3 Active, not recruiting June 2019 United States, Massachusetts ... More >> Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, New York Albert Einstein Cancer Center at Albert Einstein College of Medicine Bronx, New York, United States, 10461 Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center New York, New York, United States, 10032 James P. Wilmot Cancer Center at University of Rochester Medical Center Rochester, New York, United States, 14642 United States, Rhode Island Hasbro Children's Hospital Providence, Rhode Island, United States, 02903 United States, Virginia INOVA Fairfax Hospital Fairfax, Virginia, United States, 22031 Canada, Ontario McMaster Children's Hospital at Hamilton Health Sciences Hamilton, Ontario, Canada, L8N 3Z5 Canada, Quebec Hopital Sainte Justine Montreal, Quebec, Canada, H3T 1C5 Centre de Recherche du Centre Hospitalier de l'Universite Laval Sainte Foy, Quebec, Canada, GIV 4G2 Puerto Rico San Jorge Children's Hospital Santurce, Puerto Rico, 00912 Less <<
NCT03063983 Osteosarcoma Phase 2 Recruiting January 31, 2022 Brazil ... More >> Grupo de Apoio ao Adolescente e a Criança com Câncer Recruiting Sao Paulo, Brazil, 04039001 Contact: Antonio S Petrilli    +55 (11) 5080-8400    sergiopetrilli@graacc.org.br    Contact: Andreza A Senerchia    +55 (11) 5080-8400    andrezasenerchia@graacc.org.br Less <<
NCT00019864 Cardiac Toxicity ... More >> Sarcoma Less << Phase 2 Terminated - United States, Maryland ... More >> Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office Bethesda, Maryland, United States, 20892-1182 United States, Oklahoma Oklahoma University Cancer Institute Oklahoma City, Oklahoma, United States, 73104 United States, Texas Cook Children's Medical Center - Fort Worth Fort Worth, Texas, United States, 76104 Texas Children's Cancer Center and Hematology Service at Texas Children's Hospital Houston, Texas, United States, 77030-2399 Less <<
NCT00334867 Sarcoma Phase 3 Withdrawn(withdrawn) - -
NCT00581360 Adenoid Cystic Carcinoma Phase 2 Completed - United States, Ohio ... More >> UPMC Cancer Center - Teramana Cancer Center - Steubenville Steubenville, Ohio, United States, 43952 United States, Pennsylvania UPMC Cancer Center - Beaver Beaver, Pennsylvania, United States, 15009 UPMC Cancer Center - Clairton Clairton, Pennsylvania, United States, 15025 UPMC Cancer Center - Arnold Palmer Pavilion - Greensburg Greensburg, Pennsylvania, United States, 15601 UPMC Cancer Center - Oakbrook Commons - Greensburg Greensburg, Pennsylvania, United States, 15601 UPMC Cancer Center - Indiana Indiana, Pennsylvania, United States, 15701 UPMC Cancer Center - John P. Murtha Pavilion - Johnstown Johnstown, Pennsylvania, United States, 15901 UPMC Cancer Center - McKeesport McKeesport, Pennsylvania, United States, 15132 UPMC Cancer Center -Haymaker Rd. Monroeville, Pennsylvania, United States, 15146 UPMC Cancer Center -Mosside Blvd. Monroeville, Pennsylvania, United States, 15146 UPMC Cancer Center - Sewickley Medical Oncology/Hematology Group Moon Township, Pennsylvania, United States, 15108 UPMC Cancer Center -Mt. Pleasant Mt. Pleasant, Pennsylvania, United States, 15666 UPMC Cancer Center -New Castle New Castle, Pennsylvania, United States, 16105 UPMC Cancer Center -Delafield Rd. Pittsburgh, Pennsylvania, United States, 15215 UPMC Cancer Center - Mercy Pittsburgh, Pennsylvania, United States, 15219 University of Pittsburgh Cancer Institute-Hillman Cancer Center Pittsburgh, Pennsylvania, United States, 15232 UPMC Cancer Center - Passavant Pittsburgh, Pennsylvania, United States, 15237 UPMC Cancer Center -Drake Pittsburgh, Pennsylvania, United States, 15241 UPMC Cancer Center - Uniontown Uniontown, Pennsylvania, United States, 15401 UPMC Cancer Center - Washington Washington, Pennsylvania, United States, 15301 UPMC Cancer Center -Wexford Wexford, Pennsylvania, United States, 15090 Less <<
NCT03007147 B Acute Lymphoblastic Leukemia... More >> BCR-ABL1 Fusion Protein Expression Minimal Residual Disease Philadelphia Chromosome Positive T Acute Lymphoblastic Leukemia Untreated Adult Acute Lymphoblastic Leukemia Untreated Childhood Acute Lymphoblastic Leukemia Less << Phase 3 Recruiting June 30, 2026 -
NCT03126916 Childhood Ganglioneuroblastoma... More >> Childhood Neuroblastoma INRG Stage L2 INRG Stage M INRG Stage MS NMYC Gene Amplification Recurrent Neuroblastoma Less << Phase 3 Recruiting June 30, 2026 -
NCT00581360 - Completed - -
NCT01864109 Newly Diagnosed Ewing Sarcoma Phase 2 Recruiting May 2020 United States, New Jersey ... More >> Memoral Sloan Kettering Cancer Center Recruiting Basking Ridge, New Jersey, United States, 07920 Contact: Paul Meyers, MD    212-639-5952       Memorial Sloan Kettering Monmouth Recruiting Middletown, New Jersey, United States, 07748 Contact: Paul Meyers, MD    212-639-5952       United States, New York Memorial Sloan Kettering Commack Recruiting Commack, New York, United States, 11725 Contact: Paul Meyers, MD    212-639-5952       Memorial Sloan Kettering Westchester Recruiting Harrison, New York, United States, 10604 Contact: Paul Meyers, MD    212-639-5952       Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Paul Meyers, MD    212-639-5952       Contact: Emily Slotkin, MD    212-639-8856       Principal Investigator: Paul Meyers, MD          Memorial Sloan Kettering Rockville Centre Recruiting Rockville Centre, New York, United States, 11570 Contact: Paul Meyers, MD    212-639-5952 Less <<
NCT00004853 Ewing's Sarcoma ... More >> Rhabdomyosarcoma MPNST Synovial Sarcoma High-risk Sarcoma Less << Phase 1 Completed - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT03166813 Cardiotoxicity Not Applicable Recruiting December 31, 2020 Hong Kong ... More >> Queen Mary Hospital Recruiting Hong Kong, Hong Kong Contact: Yiu-fai Cheung, MD    852-22554091    xfcheung@hkucc.hku.hk    Principal Investigator: Yiu-fai Cheung, MD          Sub-Investigator: Daniel KL Cheuk, MBBS          Sub-Investigator: Vivian WY Li, PhD Less <<
NCT00084838 - Completed - -
NCT00400946 - Active, not recruiting - -
NCT03164057 Acute Myeloid Leukemia ... More >> Myelodysplastic Syndromes Less << Phase 2 Recruiting June 2027 United States, California ... More >> City of Hope Comprehensive Cancer Center Recruiting Duarte, California, United States, 91010 Contact: Weili Sun, MD,PhD    800-826-4673    weilisun@coh.org    Principal Investigator: Weili Sun, MD,PhD          Children's Hospital of Central California Recruiting Madera, California, United States, 93636 Contact: Faisal Razzaqi, MD    866-353-5437    frazzaqi@valleychildrens.org    Principal Investigator: Faisal Razzaqi, MD          Children's Hospital of Orange County Recruiting Orange, California, United States, 92968 Contact: Jamie Frediani, MD    714-509-4348    jfrediani@choc.org    Principal Investigator: Jamie Frediani, MD          Lucile Packard Children's Hospital Stanford University Recruiting Palo Alto, California, United States, 94304 Contact: Norman J. Lacayo, MD    650-497-8953    lacayon@stanford.edu    Principal Investigator: Norman J. Lacayo, MD          Rady Children's Hospital and Health Center Recruiting San Diego, California, United States, 92123 Contact: Deborah Schiff, MD    858-966-5983    dschiff@chsd.org    Principal Investigator: Deborah Schiff, MD          United States, Tennessee St. Jude Children's Research Hospital Recruiting Memphis, Tennessee, United States, 38105 Contact: Tanja A. Gruber, MD, PhD    866-278-5833    tanja.gruber@stjude.org    Contact: Referral Office    866-278-5833    referralinfo@stjude.org    Principal Investigator: Tanja A. Gruber, MD, PhD          United States, Texas Cook Children's Medical Center Recruiting Fort Worth, Texas, United States, 76104 Contact: Kenneth M. Heym, MD    682-885-4007    kenneth.heym@cookchildrens.org    Principal Investigator: Kenneth M. Heym, MD Less <<
NCT03020030 Acute Lymphoblastic Leukemia, ... More >>Pediatric Less << Phase 3 Recruiting December 2026 United States, Massachusetts ... More >> Boston Children's Hospital Recruiting Boston, Massachusetts, United States, 02115 Contact: Lewis Silverman, MD    617-632-6191    lewis_silverman@dfci.harvard.edu    Principal Investigator: Lewis Silverman, MD          Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Lewis Silverman, MD    617-632-6191    lewis_silverman@dfci.harvard.edu    Principal Investigator: Lewis Silverman, MD          United States, New York Montefiore Medical Center Recruiting Bronx, New York, United States, 104617 Contact: Lisa Gennarini, MD       lfigueir@montefiore.org    Roswell Park Cancer Institute Recruiting Buffalo, New York, United States, 14263 Contact: Kara Kelly, MD       Kara.Kelly@RoswellPark.org    Columbia University Medical Center, Morgan Stanley Children's Hospital of New York-Presbyterian Recruiting New York, New York, United States, 10032 Contact: Justine Kahn, MD       jk2034@cumc.columbia.edu    Principal Investigator: Justine Kahn, MD          United States, Rhode Island Hasbro Children's Hospital / Rhode Island Hospital Recruiting Providence, Rhode Island, United States, 02903 Contact: Jennifer Welch, MD       jwelch@lifespan.org    Canada, Quebec Hospital Sainte Justine, University of Montreal Recruiting Montreal, Quebec, Canada Contact: Jean-Marie LeClerc, MD       jean-marie.leclerc@umontreal.ca    Principal Investigator: Jean-Marie LeClerc, MD          Centre Hospitalier U. de Quebec Recruiting Quebec City, Quebec, Canada Contact: Bruno Michon, MD       bruno.michon@mail.chuq.qc.ca    Principal Investigator: Bruno Michon, MD Less <<
NCT00980460 Alpha Fetoprotein Increased ... More >> PRETEXT Stage 1 Hepatoblastoma PRETEXT Stage 2 Hepatoblastoma PRETEXT Stage 3 Hepatoblastoma PRETEXT Stage 4 Hepatoblastoma Less << Phase 3 Active, not recruiting December 31, 2018 -
NCT02953184 Antineoplastic Combined Chemot... More >>herapy Protocols Less << Phase 2 Recruiting November 2020 China, Jilin ... More >> First Hospital of Jilin University Recruiting Changchun, Jilin, China, 130021 Contact: Aiping Shi, Doctor    0086-13364308696    13364308696@163.com    Contact: Zhimin Fan, Doctor    0086-13756661286    fanzhimn@163.com    Sub-Investigator: Di Wu, Doctor          Sub-Investigator: Hongyao Jia, Master          Sub-Investigator: Xin Guan, Master          Principal Investigator: Zhimin Fan, Doctor          Principal Investigator: Haibo Wang, Doctor          Sub-Investigator: Gang Nie, Doctor Less <<
NCT00084838 Central Nervous System Tumor, ... More >>Pediatric Less << Phase 2 Completed - United States, California ... More >> Stanford Cancer Center Stanford, California, United States, 94305-5826 United States, Connecticut Yale Cancer Center New Haven, Connecticut, United States, 06520-8028 United States, Georgia AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish Rite Campus Atlanta, Georgia, United States, 30342 United States, Illinois Children's Memorial Hospital - Chicago Chicago, Illinois, United States, 60614 United States, Maryland Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21231-2410 United States, Massachusetts Children's Hospital Boston Boston, Massachusetts, United States, 02115 Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, Minnesota Children's Hospitals and Clinics of Minnesota - Minneapolis Minneapolis, Minnesota, United States, 55404 United States, Nevada Sunrise Hospital and Medical Center Las Vegas, Nevada, United States, 89109 United States, Ohio Cleveland Clinic Taussig Cancer Center Cleveland, Ohio, United States, 44195 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 United States, Texas Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas Dallas, Texas, United States, 75390 Less <<
NCT00165087 Acute Lymphoblastic Leukemia Phase 3 Terminated(Terminated by IRB f... More >>or continuing review) Less << - United States, Louisiana ... More >> Ochsner Clinic New Orleans, Louisiana, United States, 70121 United States, Maine Maine Medical Center Lewiston, Maine, United States, 04240 United States, Massachusetts Children's Hospital Boston Boston, Massachusetts, United States, 02115 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, New York Mt. Sinai Medical Center New York, New York, United States, 10029 University of Rochester Rochester, New York, United States, 14627 Canada, Ontario McMaster University Hamilton, Ontario, Canada Canada, Quebec Laval University Montreal, Quebec, Canada Sainte Justine Hosptial Montreal, Quebec, Canada Puerto Rico San Jorge Children's Hospital Santurce, Puerto Rico, 00912 Less <<
NCT01871766 Rhabdomyosarcoma Phase 2 Recruiting June 2024 United States, Florida ... More >> University of Florida Proton Therapy Institute Active, not recruiting Jacksonville, Florida, United States, 32206 Nemours Children's Clinic Active, not recruiting Jacksonville, Florida, United States, 32207 United States, Tennessee St. Jude Children's Research Hospital Recruiting Memphis, Tennessee, United States, 38105 Contact: Matthew J. Krasin, MD    866-278-5833    referralInfo@stjude.org    Principal Investigator: Matthew J. Krasin, MD          United States, Texas Cook Children's Medical Center Recruiting Fort Worth, Texas, United States, 76104 Contact: Karen Albritton, MD    682-885-2103    karen.albritton@cookchildrens.org    Principal Investigator: Karen Albritton, MD Less <<
NCT00742924 Sarcoma Phase 1 Completed - -
NCT00410488 Sarcoma Nause... More >>a Vomiting Less << Not Applicable Completed - United States, Texas ... More >> UT MD Anderson Cancer Center Houston, Texas, United States, 77030 Less <<
NCT00410488 - Completed - -
NCT00673179 Osteosarcoma Not Applicable Terminated(Low accrual.) - United States, Texas ... More >> UT MD Anderson Cancer Center Houston, Texas, United States, 77030 Less <<
NCT00673179 - Terminated(Low accrual.) - -
NCT00098839 Recurrent Childhood Acute Lymp... More >>hoblastic Leukemia Less << Phase 1 Phase 2 Completed - -
NCT00001335 Ewing's Sarcoma ... More >> Neuroblastoma Rhabdomyosarcoma Less << Phase 2 Completed - United States, Maryland ... More >> National Cancer Institute (NCI) Bethesda, Maryland, United States, 20892 Less <<
NCT00165178 Acute Lymphoblastic Leukemia Phase 3 Completed - United States, Massachusetts ... More >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Less <<
NCT00098839 - Completed - -
NCT01258634 Osteosarcoma ... More >>Lung Metastases Less << Phase 1 Terminated(PI no longer affili... More >>ated with institution; only 2 subjects enrolled) Less << - United States, Illinois ... More >> University of Chicago Department of Pediatrics Hematology/Oncology Chicago, Illinois, United States, 60637 Less <<
NCT01606878 Recurrent Childhood Anaplastic... More >> Large Cell Lymphoma Recurrent Neuroblastoma Unspecified Childhood Solid Tumor, Protocol Specific Less << Phase 1 Active, not recruiting - -
NCT03698227 Advanced Soft Tissue Sarcoma Phase 2 Not yet recruiting December 31, 2019 Germany ... More >> Helios Klinikum Bad Saarow Not yet recruiting Bad Saarow, Germany, 15526 Contact: Daniel Pink, MD Less <<
NCT00003667 Sarcoma Phase 2 Completed - United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 United States, Texas University of Texas - MD Anderson Cancer Center Houston, Texas, United States, 77030 Less <<
NCT01523977 Acute Lymphoblastic Leukemia Phase 1 Active, not recruiting November 2018 United States, California ... More >> UCSF San Francisco, California, United States, 94143 United States, Colorado Children's Hospital Colorado Aurora, Colorado, United States, 80045 United States, Georgia Children's Healthcare of Atlanta Atlanta, Georgia, United States, 30322 United States, Illinois Ann & Robert H. Lurie Children's Hospital of Chicago Chicago, Illinois, United States, 60611 United States, Massachusetts Boston Children's Hospital Boston, Massachusetts, United States, 02115 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, New York Columbia University Medical Center New York, New York, United States, 12549 United States, Washington Seattle Children's Hospital Seattle, Washington, United States, 98105 Less <<
NCT01230983 Cardiac Toxicity ... More >> Leukemia Lymphoma Less << Phase 3 Completed - -
NCT00544778 Sarcoma Phase 2 Terminated(The study was termi... More >>nated prematurely due to withdrawal of support by the sponsor.) Less << - -
NCT01696669 Ewing's Sarcoma Phase 2 Completed - Spain ... More >> Hospital Clínic de Barcelona Barcelona, Spain Hospital de la Santa Creu i Sant Pau Barcelona, Spain Hospital Vall d'Hebron Barcelona, Spain Hospital Sant Joan de Déu Esplugues de Llobregat, Spain Institut Català d'Oncologia l'Hospitalet Hospitalet de Llobregat, Spain Hospital Universitario de Canarias La Laguna, Spain Hospital Ramón y Cajal Madrid, Spain, 28034 Hospital Son Espases Palma de Mallorca, Spain Hospital Universitario Miguel Servet Zaragoza, Spain Less <<
NCT00039481 Cardiac Toxicity ... More >> Unspecified Childhood Solid Tumor, Protocol Specific Less << Phase 1 Completed - United States, California ... More >> Children's Oncology Group Arcadia, California, United States, 91006-3776 Less <<
NCT00005578 Cardiac Toxicity ... More >> Lymphoma Less << Phase 3 Completed - -
NCT00011414 Wilms' Tumor ... More >>Sarcoma Adenaocortical Carcinoma Refractory Cancer Coldrhood Cancer Less << Phase 1 Completed - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT00002827 Cardiac Toxicity ... More >> Lymphoma Less << Phase 3 Completed - -
NCT00003937 Cardiac Toxicity ... More >> Sarcoma Less << Phase 3 Completed - -
NCT00016276 Cardiac Toxicity ... More >> Inflammatory Breast Cancer Stage IIIA Breast Cancer Stage IIIB Breast Cancer Stage IV Breast Cancer Less << Phase 3 Terminated(Administratively co... More >>mplete.) Less << - United States, Illinois ... More >> Cancer and Leukemia Group B Chicago, Illinois, United States, 60606 Less <<
NCT01790152 - Recruiting - -
NCT00038142 Ewing's Sarcoma Phase 2 Terminated(Low Accrual) - United States, Texas ... More >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Less <<
NCT00548561 Anthracycline Extravasation Phase 2 Phase 3 Completed - Denmark ... More >> Aalborg Hospital South Aalborg, Denmark, 9100 Rigshospitalet Copenhagen, Denmark, 2100 Herlev County Hospital Herlev, Denmark, 2730 Herlev Hospital Hematological Department Herlev, Denmark, 2730 Herning District Hospital Herning, Denmark, 7400 Hilleroed Hospital Hilleroed, Denmark, 3400 Odense University Hospital Odense, Denmark, 5000 C Roskilde County Hospital Roskilde, Denmark, 4000 Viborg Hospital Viborg, Denmark, 8800 Less <<
NCT00550901 Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << Phase 1 Completed - -
NCT00933985 Acute Leukemias of Ambiguous L... More >>ineage Acute Undifferentiated Leukemia Angioimmunoblastic T-cell Lymphoma Blastic Phase Chronic Myelogenous Leukemia Childhood Burkitt Lymphoma Childhood Chronic Myelogenous Leukemia Childhood Diffuse Large Cell Lymphoma Childhood Immunoblastic Large Cell Lymphoma Childhood Nasal Type Extranodal NK/T-cell Lymphoma Cutaneous B-cell Non-Hodgkin Lymphoma Hepatosplenic T-cell Lymphoma Intraocular Lymphoma Noncutaneous Extranodal Lymphoma Peripheral T-cell Lymphoma Recurrent Childhood Acute Lymphoblastic Leukemia Recurrent Childhood Acute Myeloid Leukemia Recurrent Childhood Anaplastic Large Cell Lymphoma Recurrent Childhood Grade III Lymphomatoid Granulomatosis Recurrent Childhood Large Cell Lymphoma Recurrent Childhood Lymphoblastic Lymphoma Recurrent Childhood Small Noncleaved Cell Lymphoma Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma Recurrent Mycosis Fungoides/Sezary Syndrome Recurrent/Refractory Childhood Hodgkin Lymphoma Refractory Chronic Lymphocytic Leukemia Refractory Hairy Cell Leukemia Relapsing Chronic Myelogenous Leukemia Small Intestine Lymphoma Unspecified Childhood Solid Tumor, Protocol Specific Less << Phase 1 Terminated - -
NCT03589729 Acute Myeloid Leukemia ... More >> Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive Blasts 10 Percent or More of Bone Marrow Nucleated Cells High Risk Myelodysplastic Syndrome Myeloid Sarcoma Myeloproliferative Neoplasm Philadelphia Chromosome Positive Less << Phase 2 Recruiting December 31, 2020 United States, Texas ... More >> M D Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Maro Ohanian    713-792-2631       Principal Investigator: Maro Ohanian Less <<
NCT00544778 - Terminated(The study was termi... More >>nated prematurely due to withdrawal of support by the sponsor.) Less << - -
NCT01596088 Extravasations of Anthracyclin... More >>e Anti-cancer Agents Less << Phase 1 Phase 2 Completed - Japan ... More >> Japan Tokyo and Other Japanese City, Japan Less <<
NCT01596088 - Completed - -
NCT00955890 Breast Cancer Phase 2 Terminated(Enrolled too slow) - China, Shanghai ... More >> Fudan University Cancer Hospital Shanghai, Shanghai, China, 200032 Less <<
NCT01627938 Multiple Sclerosis Phase 2 Unknown April 2016 Germany ... More >> Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum Bochum, Germany, 44791 Less <<
NCT00548704 Extravasation Phase 2 Phase 3 Completed - Denmark ... More >> Aalborg Hospital South Aalborg, Denmark, 9100 Aarhus County Hospital Aarhus, Denmark, 8000 C Aarhus Municipality Hospital Aarhus, Denmark, 8000 C Rigshospitalet, Haematology Department Copenhagen, Denmark, 2100 Rigshospitalet, Oncology Department Copenhagen, Denmark, 2100 Esbjerg District Hospital Esbjerg, Denmark, 6700 Herlev County Hospital, Haematology Department Herlev, Denmark, 2730 Herlev County Hospital, Oncology Department Herlev, Denmark, 2730 Hilleroed Hospital Hilleroed, Denmark, 3400 Naestved District Hospital Naestved, Denmark, 4700 Odense University Hospital Odense, Denmark, 5000 C Roskilde County Hospital Roskilde, Denmark, 4000 Soenderborg Hospital Soenderborg, Denmark, 6400 Vejle Hospital Vejle, Denmark, 7100 Viborg Hospital Viborg, Denmark, 8800 Germany Evangelisches Bethesda Krankenhaus Essen Borbak Statt, Germany, 45355 Klinik für Gynäkologie und Geburtshilfe Frankfurt am Main, Germany, 60590 Klinik und Poliklinik für Innere Medizin Hamburg, Germany, 20246 Medizinische Hochschule Hannover Hannover, Germany, 30659 Universitäts Frauenklinik Kiel, Germany, 24105 Universitäts Medizinische Klinik Kiel, Germany, 24105 Frauenklinik com Roten Kreuz Munich, Germany, 80637 Universitäts Frauenklinik Rostock, Germany, 18057 Klinik für Gynäkologie und Gynäkologische Onkologie Wiesbaden, Germany, 65199 Italy Ospedale G.B. Morgagni L. Pierantoni Forli, Italy, 47100 Presidio Ospedaliero di Ravenna Ravenna, Italy, 48100 Ospedale degli Infermi Rimini, Italy, 47037 Ospedali Riuniti Trieste, Italy, 34100 Netherlands Netherland Cancer Institute Amsterdam, Netherlands, 1066 CX University Hospital Groningen, Netherlands, 9700 RB Willem Alexander Hospital Hertogenbosch, Netherlands, 5223 GV Poland Centre of Oncology - Krakow Division Krakow, Poland, 31-115 Maria Sklodowska-Curie Memorial Cancer Center Warsaw, Poland, 02-781 Dolnoslaski Centrum Onkologii oddzial Chemoterapii Wroclaw, Poland, 53-413 Less <<
NCT02519335 Heart Defects, Congenital Phase 1 Terminated(PI no longer at thi... More >>s facility) Less << - United States, Texas ... More >> Medical City Children's Hospital Dallas, Texas, United States, 75230 Less <<
NCT00742924 - Completed - -
NCT02584309 Sarcoma, Soft Tissue ... More >> Soft Tissue Sarcoma Undifferentiated Pleomorphic Sarcoma Leiomyosarcoma Liposarcoma Synovial Sarcoma Myxofibrosarcoma Angiosarcoma Fibrosarcoma Malignant Peripheral Nerve Sheath Tumor Epithelioid Sarcoma Less << Phase 2 Recruiting October 31, 2023 United States, Missouri ... More >> Washington University School of Medicine Recruiting Saint Louis, Missouri, United States, 63110 Contact: Brian A Van Tine, M.D., Ph.D.    314-747-8475    bvantine@wustl.edu    Principal Investigator: Brian A Van Tine, M.D., Ph.D.          Sub-Investigator: Ashley E Frith, M.D.          Sub-Investigator: Douglas R Adkins, M.D.          Sub-Investigator: Ronald J Krone, M.D.          Sub-Investigator: Justin Vader, M.D.          Sub-Investigator: George Heberton, M.D.          Sub-Investigator: Peter Oppelt, M.D.          Sub-Investigator: Caron Rigden, M.D.          Sub-Investigator: Angela Hirbe, M.D. Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.73mL

0.75mL

0.37mL

18.64mL

3.73mL

1.86mL

37.28mL

7.46mL

3.73mL

References

[1]Shaikh F, Dupuis LL, et al. Cardioprotection and Second Malignant Neoplasms Associated With Dexrazoxane in Children Receiving Anthracycline Chemotherapy: A Systematic Review and Meta-Analysis. J Natl Cancer Inst. 2015 Nov 23;108(4). pii: djv357.

[2]Jones, R.L. Utility of dexrazoxane for the reduction of anthracycline-induced cardiotoxicity. Expert Rev Cardiovasc Ther, 2008. 6(10): p. 1311-7.

[3]Jones RL. Utility of dexrazoxane for the reduction of anthracycline-induced cardiotoxicity. Expert Rev Cardiovasc Ther. 2008 Nov;6(10):1311-7

[4]Loyevsky M, Sacci JB Jr, Boehme P, Weglicki W, John C, Gordeuk VR. Plasmodium falciparum and Plasmodium yoelii: effect of the iron chelation prodrug dexrazoxane on in vitro cultures. Exp Parasitol. 1999 Feb;91(2):105-14

[5]Getz KD, Sung L, Alonzo TA, Leger KJ, Gerbing RB, Pollard JA, Cooper T, Kolb EA, Gamis AS, Ky B, Aplenc R. Effect of Dexrazoxane on Left Ventricular Systolic Function and Treatment Outcomes in Patients With Acute Myeloid Leukemia: A Report From the Children's Oncology Group. J Clin Oncol. 2020 Jul 20;38(21):2398-2406

[6]Yu X, Ruan Y, Shen T, Qiu Q, Yan M, Sun S, Dou L, Huang X, Wang Q, Zhang X, Man Y, Tang W, Jin Z, Li J. Dexrazoxane Protects Cardiomyocyte from Doxorubicin-Induced Apoptosis by Modulating miR-17-5p. Biomed Res Int. 2020 Mar 1;2020:5107193

[7]Li L, Nie X, Zhang P, Huang Y, Ma L, Li F, Yi M, Qin W, Yuan X. Dexrazoxane ameliorates radiation-induced heart disease in a rat model. Aging (Albany NY). 2021 Jan 2;13(3):3699-3711

 

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