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Chemical Structure| 171596-36-4 Chemical Structure| 171596-36-4
Chemical Structure| 171596-36-4

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Nortadalafil

CAS No.: 171596-36-4

Nortadalafil is demethyl tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) and pulmonary arterial hypertension.

Synonyms: Demethyl Tadalafil

4.5 *For Research Use Only !

Cat. No.: A215860 Purity: 98%

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Product Details of [ Nortadalafil ]

CAS No. :171596-36-4
Formula : C21H17N3O4
M.W : 375.38
SMILES Code : O=C([C@@]1([H])CC2=C([C@@H](C3=CC=C(OCO4)C4=C3)N15)NC6=C2C=CC=C6)NCC5=O
Synonyms :
Demethyl Tadalafil
MDL No. :MFCD19443817
InChI Key :XHDLVMPUSXRZOS-FOIQADDNSA-N
Pubchem ID :9820973

Safety of [ Nortadalafil ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

ALK Isoform Comparison

Name PDE PDE1 PDE10A PDE2 PDE3 PDE4 PDE5 PDE6 Purity
Deltarasin +++

PDEδ , Kd: 38 nM

96%
7-(2,3-Dihydroxypropyl)theophylline 98%
Aminophylline +

PDE, IC50: 0.12 mM

98+%
Anagrelide HCl 99%
Irsogladine 99%
PF-8380 +++

Autotaxin, IC50: 2.8 nM

99%
Dipyridamole 98%
Balipodect ++++

PDE10A, IC50: 0.3 nM

98+%
PF-2545920 ++++

PDE10A, IC50: 0.37 nM

97%
Milrinone ++

PDE2, IC50: 5.2 μM

++

PDE3, IC50: 2.1 μM

99%
Pimobendan ++

PDE3, IC50: 0.32 μM

98%
Cilostazol ++

PDE3, IC50: 0.2 μM

98%
(S)-(+)-Rolipram ++

PDE4, IC50: 0.75 μM

99% (HPLC)
Luteolin +

PDE1, Ki: 15.0 μM

++

PDE2, Ki: 6.4 μM

+

PDE3, Ki: 13.9 μM

+

PDE4, Ki: 11.1 μM

+

PDE5, Ki: 9.5 μM

98%
Apremilast +++

PDE4, IC50: 74 nM

98%
GSK256066 ++++

PDE4B, IC50: 3.2 pM

98+%
Roflumilast ++++

PDE4A1, IC50: 0.7 nM

PDE4A4, IC50: 4.3 nM

99%
Rolipram +++

PDE4B, IC50: 130 nM

98%
Cilomilast +++

HPDE4, IC50: 120 nM

LPDE4, IC50: 100 nM

99%
Fenspiride HCl +

PDE3, pIC50: 3.44

+

PDE4, pIC50: 4.16

99% (HPLC)
Avanafil ++++

PDE5, IC50: 1 nM

98%
Vardenafil HCl Trihydrate ++++

PDE5, IC50: 0.7 nM

98%
Tadalafil ++++

PDE5, IC50: 1.8 nM

98%
Icariin ++

PDE5, IC50: 0.432 μM

98%

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.66mL

0.53mL

0.27mL

13.32mL

2.66mL

1.33mL

26.64mL

5.33mL

2.66mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline
Solubility: ≥ 2.5 mg/mL (6.66 mM); Clear solution
Protocol 2
Add each solvent one by one:  10% DMSO    90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.66 mM); Clear solution

References

 

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