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Chemical Structure| 1173204-81-3 Chemical Structure| 1173204-81-3
Chemical Structure| 1173204-81-3

PKI-402

CAS No.: 1173204-81-3

PKI-402 is a potent dual pan-PI3K/mTOR inhibitor targeting PI3Kα/β/γ/δ and mTOR with IC50 of 2 nM/7 nM/16 nM/14 nM and 3 nM.

4.5 *For Research Use Only !

Cat. No.: A786338 Purity: 98%

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Product Details of [ PKI-402 ]

CAS No. :1173204-81-3
Formula : C29H34N10O3
M.W : 570.65
SMILES Code : O=C(NC1=CC=C(C(N2CCN(C)CC2)=O)C=C1)NC3=CC=C(C4=NC(N5CCOCC5)=C(N=NN6CC)C6=N4)C=C3
MDL No. :MFCD18251484

Safety of [ PKI-402 ]

Biological Activity

Target
  • p110γ

    PI3Kγ, IC50:16 nM

  • p110β

    PI3Kβ, IC50:7 nM

  • p110α

    PI3Kα, IC50:2 nM

  • p110δ

    PI3Kδ, IC50:14 nM

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.75mL

0.35mL

0.18mL

8.76mL

1.75mL

0.88mL

17.52mL

3.50mL

1.75mL

Dissolving Methods
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Add each solvent one by one:  50% PEG300    50% Saline
Solubility: 1.43 mg/mL (2.51 mM); Suspended solution; Need ultrasonic

References

 

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