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With semicarbazide hydrochloride; potassium acetate In water at 20℃; Large scale;
1.4 Synthesis of adrenal hydrazone
Add hydrogenation mother liquor to 3000L kettle, add filtered potassium ferricyanide 266kg+sodium bicarbonate 125Kg+950kg aqueous solution at 0-5, stir for 15min, then add filtered semicarbazide hydrochloride 60kg+potassium acetate 52kg+283kg aqueous solution, room temperature Stir for 23h, let stand for 5 hours, centrifuge, take out the solids and make a slurry with water, centrifuge, take out the solids and add them to the kettle, stir and wash with 10 times the amount of water at 70 for 1 hour, centrifuge and spin dry the resulting product, the color of the product is orange , Sticky.
Multi-step reaction with 5 steps
1.1: aluminum (III) chloride / dichloromethane / 0 - 30 °C / Large scale
2.1: ethanol / 10 - 45 °C / Large scale
2.2: 5 h / 0 - 10 °C / Large scale
3.1: sodium tetrahydroborate; pyrographite / water / 25 °C / Large scale
4.1: potassium hexacyanoferrate(III); sodium hydrogencarbonate / water / 0.25 h / 0 - 5 °C / Large scale
5.1: semicarbazide hydrochloride; potassium acetate / water / 20 °C / Large scale
Multi-step reaction with 4 steps
1.1: ethanol / 10 - 45 °C / Large scale
1.2: 5 h / 0 - 10 °C / Large scale
2.1: sodium tetrahydroborate; pyrographite / water / 25 °C / Large scale
3.1: potassium hexacyanoferrate(III); sodium hydrogencarbonate / water / 0.25 h / 0 - 5 °C / Large scale
4.1: semicarbazide hydrochloride; potassium acetate / water / 20 °C / Large scale
Multi-step reaction with 3 steps
1: sodium tetrahydroborate; pyrographite / water / 25 °C / Large scale
2: potassium hexacyanoferrate(III); sodium hydrogencarbonate / water / 0.25 h / 0 - 5 °C / Large scale
3: semicarbazide hydrochloride; potassium acetate / water / 20 °C / Large scale