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Chemical Structure| 1648863-90-4 Chemical Structure| 1648863-90-4
Chemical Structure| 1648863-90-4

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G-5555

CAS No.: 1648863-90-4

G-5555 is a selective PAK1 inhibitor with a Ki value of 3.7 nM, used for studying PAK-related disease mechanisms.

4.5 *For research use only!

Cat. No.: A102618 Purity: 99%

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Product Details of [ G-5555 ]

CAS No. :1648863-90-4
Formula : C25H25ClN6O3
M.W : 492.96
MDL No. :MFCD28506227

Safety of [ G-5555 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of [ G-5555 ]

cytoskeleton

ALK Isoform Comparison

Name PAK PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 Purity
PF-3758309 ++++

PAK6, Ki: 17.1 nM

PAK3, IC50: 190 nM

++++

PAK1, Ki: 13.7 nM

+

PAK2, IC50: 190 nM

++

PAK3, IC50: 99 nM

+++

PAK4, Ki: 18.7 nM

+++

PAK5, Ki: 18.1 nM

+++

PAK6, Ki: 17.1 nM

98+%
FRAX486 +++

PAK4, IC50: 39 nM

PAK1, IC50: 14 nM

+++

PAK1, IC50: 14 nM

++

PAK2, IC50: 33 nM

++

PAK3, IC50: 39 nM

+

PAK4, IC50: 575 nM

98+%
FRAX1036 ++

PAK2, Ki: 72.4 nM

PAK4, Ki: 23.3 nM

++

PAK1, Ki: 23.3 nM

++

PAK2, Ki: 72.4 nM

+

PAK4, Ki: 2.4 μM

98+%
IPA-3 +

PAK1, IC50: 2.5 μM

+

PAK1, IC50: 2.5 μM

98%
FRAX597 ++++

PAK2, IC50: 13 nM

PAK3, IC50: 13 nM

++++

PAK1, IC50: 8 nM

++++

PAK2, IC50: 13 nM

+++

PAK3, IC50: 19 nM

98+%

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.03mL

0.41mL

0.20mL

10.14mL

2.03mL

1.01mL

20.29mL

4.06mL

2.03mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

Reference

 

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