Chemistry Heterocyclic Building Blocks Pyridines isonicotinaldehyde
Aldol condensation: Isonicotinaldehyde can undergo aldol condensation reactions with itself or with other carbonyl compounds in the presence of a base or an acid catalyst, forming β-hydroxy aldehydes or β-hydroxy ketones.
Nucleophilic addition reactions: The aldehyde group in isonicotinaldehyde can undergo nucleophilic addition reactions with various nucleophiles, such as primary and secondary amines, hydrazine derivatives, and organometallic reagents.
Oxidation reactions: Isonicotinaldehyde can be oxidized to form the corresponding carboxylic acid, using oxidizing agents such as potassium permanganate (KMnO4) or chromic acid (H2CrO4).
Reduction reactions: The aldehyde group in isonicotinaldehyde can be reduced to the corresponding alcohol using reducing agents such as sodium borohydride (NaBH4) or lithium aluminum hydride (LiAlH4).
Substitution reactions: The pyridine ring in isonicotinaldehyde can undergo substitution reactions, such as electrophilic aromatic substitution, nucleophilic aromatic substitution, or metal-catalyzed cross-coupling reactions.
Condensation reactions: Isonicotinaldehyde can participate in condensation reactions with various compounds, such as aromatic amines or hydrazine derivatives, to form Schiff bases or hydrazones.
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tert-Butyl (6-fluoro-4-formylpyridin-3-yl)carbamate
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5-Bromo-2-(trifluoromethyl)isonicotinaldehyde
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tert-Butyl (5-bromo-4-formylpyridin-2-yl)carbamate