Chemistry Heterocyclic Building Blocks Pyridines 4-(bromomethyl)pyridine
Substitution Reactions: The bromine atom in the bromomethyl group can undergo substitution reactions with various nucleophiles, such as amines or thiols, leading to the formation of substituted products.
Palladium-Catalyzed Cross-Coupling Reactions: The bromomethyl group can undergo palladium-catalyzed cross-coupling reactions with organometallic reagents, such as organoboranes or organostannanes, to form biaryl or heteroaryl compounds.
Reduction Reactions: The bromomethyl group can be reduced to a methyl group using reducing agents such as lithium aluminum hydride (LiAlH4) or hydrogen gas (H2) in the presence of a metal catalyst.
Nucleophilic Addition Reactions: The pyridine ring can undergo nucleophilic addition reactions with strong nucleophiles, such as Grignard reagents or organolithium compounds, leading to the formation of substituted pyridine derivatives.
Ring-Opening Reactions: The bromomethyl group can participate in ring-opening reactions of cyclic compounds, such as epoxides or aziridines, leading to the formation of open-chain products with an appended pyridine moiety.
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2-Bromo-4-(bromomethyl)pyridine hydrobromide
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4-(Bromomethyl)-2-(trifluoromethyl)pyridine
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4-(Bromomethyl)-2-methoxypyridine hydrobromide
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4-(Bromomethyl)-2-methylpyridine hydrobromide
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4-(Bromomethyl)-2-chloropyridine hydrobromide