Chemistry Heterocyclic Building Blocks Pyridines 6-chloronicotinaldehyde
Nucleophilic Substitution: The chlorine atom can undergo nucleophilic substitution reactions with nucleophiles such as amines, thiols, or cyanide ions to form corresponding substitution products.
Reduction: The aldehyde group of 6-chloronicotinaldehyde can be reduced to an alcohol group using reducing agents such as sodium borohydride or lithium aluminum hydride.
Aromatic Substitution: The aromatic ring of 6-chloronicotinaldehyde can undergo electrophilic aromatic substitution reactions with strong electrophiles, such as nitration, sulfonation, or Friedel-Crafts acylation/alkylation.
Oxidation: The aldehyde group can be oxidized to a carboxylic acid group using mild oxidizing agents such as chromic acid or potassium permanganate.
Condensation Reactions: 6-Chloronicotinaldehyde can undergo condensation reactions with various nucleophiles, such as primary amines or hydrazine, to form Schiff bases or hydrazones.
Cross-Coupling Reactions: In the presence of appropriate catalysts, 6-chloronicotinaldehyde can undergo cross-coupling reactions with organometallic reagents like Grignard reagents or organozinc compounds to form carbon-carbon bonds.
Heterocyclic Synthesis: 6-Chloronicotinaldehyde can participate in various heterocyclic synthesis reactions, such as the Hantzsch synthesis, to form heterocyclic compounds.
Michael Addition: The double bond present in the molecule can undergo Michael addition reactions with nucleophiles containing active hydrogen atoms, such as enolates or thiols.
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N-(6-Chloro-3-formylpyridin-2-yl)pivalamide
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tert-Butyl 6-chloro-3-formylpyridin-2-ylcarbamate