Alternatived Products of [ 77284-32-3 ]
Product Details of [ 77284-32-3 ] CAS No. : 77284-32-3 MDL No. : MFCD00037537 Formula :
C21 H23 NO4 Boiling Point : - Linear Structure Formula : - InChI Key : VCFCFPNRQDANPN-IBGZPJMESA-N M.W :
353.41
Pubchem ID : 7009636 Synonyms :
Fmoc-L-Norleucine
Calculated chemistry of [ 77284-32-3 ] Expand+ Physicochemical Properties Num. heavy atoms : 26 Num. arom. heavy atoms : 12 Fraction Csp3 : 0.33 Num. rotatable bonds : 9 Num. H-bond acceptors : 4.0 Num. H-bond donors : 2.0 Molar Refractivity : 99.59 TPSA : 75.63 Ų
Pharmacokinetics GI absorption : High BBB permeant : Yes P-gp substrate : No CYP1A2 inhibitor : Yes CYP2C19 inhibitor : Yes CYP2C9 inhibitor : Yes CYP2D6 inhibitor : No CYP3A4 inhibitor : Yes Log Kp (skin permeation) : -5.28 cm/s
Lipophilicity Log Po/w (iLOGP) : 2.35 Log Po/w (XLOGP3) : 4.48 Log Po/w (WLOGP) : 4.17 Log Po/w (MLOGP) : 3.0 Log Po/w (SILICOS-IT) : 3.72 Consensus Log Po/w : 3.54
Druglikeness Lipinski : 0.0 Ghose : None Veber : 0.0 Egan : 0.0 Muegge : 0.0 Bioavailability Score : 0.56
Water Solubility Log S (ESOL) : -4.6 Solubility : 0.00886 mg/ml ; 0.0000251 mol/l Class : Moderately soluble Log S (Ali) : -5.79 Solubility : 0.000575 mg/ml ; 0.00000163 mol/l Class : Moderately soluble Log S (SILICOS-IT) : -6.08 Solubility : 0.000292 mg/ml ; 0.000000826 mol/l Class : Poorly soluble
Medicinal Chemistry PAINS : 0.0 alert Brenk : 0.0 alert Leadlikeness : 3.0 Synthetic accessibility : 3.86
Application In Synthesis of [ 77284-32-3 ] * All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Downstream synthetic route of [ 77284-32-3 ]
1 [ 29022-11-5 ] [ 35737-15-6 ] [ 77128-73-5 ] [ 77284-32-3 ] Fmoc-D-Asp(t-Bu)-OH, Hpa-OSu [ No CAS ] (R)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-3-{(S)-2-[(S)-2-(2-{(S)-2-[2-(4-hydroxy-phenyl)-acetylamino]-hexanoylamino}-acetylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-N-methyl-succinamic acid [ No CAS ] 2 [ 67-56-1 ] [ 122889-11-6 ] [ 77284-32-3 ] [ 708-06-5 ] Gly-Wang resin [ No CAS ] [(S)-2-((S)-3-Benzyloxy-2-[1-(2-hydroxy-naphthalen-1-yl)-meth-(E)-ylidene]-amino}-propionylamino)-hexanoylamino]-acetic acid methyl ester [ No CAS ] 3 [ 67-56-1 ] [ 96402-49-2 ] [ 77284-32-3 ] [ 708-06-5 ] Gly-Wang resin [ No CAS ] [(S)-2-((S)-2-[1-(2-Hydroxy-naphthalen-1-yl)-meth-(E)-ylidene]-amino}-3-naphthalen-1-yl-propionylamino)-hexanoylamino]-acetic acid methyl ester [ No CAS ] 4 [ 67-56-1 ] [ 139090-50-9 ] [ 77284-32-3 ] [ 708-06-5 ] Gly-Wang resin [ No CAS ] C33 H42 N6 O7 S [ No CAS ] 5 [ 71989-18-9 ] [ 132684-59-4 ] [ 77284-32-3 ] [ 135112-28-6 ] [ 125238-99-5 ] N-(9-fluorenylmethoxycarbonyl)-3-(β-naphthyl)-L-alanine [ No CAS ] [ 1349220-85-4 ] 6 [ 159610-89-6 ] [ 68858-20-8 ] [ 71989-38-3 ] [ 71989-26-9 ] [ 77284-32-3 ] [ 94744-50-0 ] N,N'-bis(tert-butyloxycarbonyl)-L-lysine dicyclohexylamine salt [ No CAS ] [ 198561-07-8 ] [ 1443329-49-4 ] 7 [ 159610-89-6 ] [ 108-24-7 ] [ 86123-10-6 ] [ 109425-51-6 ] [ 77284-32-3 ] [ 143824-78-6 ] Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine [ No CAS ] [ 198561-07-8 ] Ac-Nle-Pra-His-D-Phe-Arg-Trp-Nle(ε-N3)-NH2 [ No CAS ] 8 [ 159610-89-6 ] [ 108-24-7 ] [ 86123-10-6 ] [ 109425-51-6 ] [ 77284-32-3 ] [ 143824-78-6 ] Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine [ No CAS ] [ 198561-07-8 ] Ac-Nle-Nle(N<SUB>3</SUB>)-His-D-Phe-Arg-Trp-Pra-NH<SUB>2</SUB> [ No CAS ] 9 [ 56-45-1 ] [ 29022-11-5 ] [ 35661-60-0 ] C22 H26 N2 O3 [ No CAS ] [ 71989-31-6 ] [ 135944-05-7 ] [ 91000-69-0 ] [ 77284-32-3 ] [ 109425-56-1 ] [ 116611-64-4 ] PyrRPRLSHKGPNleP(α-Me)Phe [ No CAS ] 10 [ 35661-60-0 ] [ 35661-39-3 ] Boc-His(Trt)-Gly-Asp(tBu)-Gly-OH [ No CAS ] [ 35661-40-6 ] [ 71989-14-5 ] [ 71989-23-6 ] [ 71989-26-9 ] [ 132388-59-1 ] [ 132327-80-1 ] [ 77284-32-3 ] [ 104091-08-9 ] [ 143824-78-6 ] Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine [ No CAS ] Fmoc-Thr(Pg)-OH [ No CAS ] Fmoc-Ser(Pg)-OH [ No CAS ] C151 H232 N42 O48 [ No CAS ] 11 [ 35661-60-0 ] [ 35661-39-3 ] Boc-His(Trt)-Gly-Asp(tBu)-Gly-OH [ No CAS ] [ 35661-40-6 ] [ 71989-14-5 ] [ 71989-18-9 ] [ 71989-23-6 ] [ 71989-26-9 ] [ 132388-59-1 ] [ 132327-80-1 ] [ 96402-49-2 ] [ 77284-32-3 ] [ 143824-78-6 ] Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine [ No CAS ] Fmoc-Thr(Pg)-OH [ No CAS ] Fmoc-Ser(Pg)-OH [ No CAS ] C160 H237 N41 O47 [ No CAS ] 12 [ 35661-60-0 ] [ 35661-39-3 ] Boc-His(Trt)-Gly-Asp(tBu)-Gly-OH [ No CAS ] [ 35661-40-6 ] [ 71989-14-5 ] [ 71989-18-9 ] [ 71989-23-6 ] [ 71989-26-9 ] [ 132388-59-1 ] [ 132327-80-1 ] [ 77284-32-3 ] [ 32926-43-5 ] [ 143824-78-6 ] Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine [ No CAS ] Fmoc-Thr(Pg)-OH [ No CAS ] Fmoc-Ser(Pg)-OH [ No CAS ] C153 H233 N43 O47 [ No CAS ] 13 [ 35661-60-0 ] [ 35661-39-3 ] Boc-His(Trt)-Gly-Asp(tBu)-Gly-OH [ No CAS ] [ 35661-40-6 ] [ 71989-14-5 ] [ 71989-18-9 ] [ 71989-23-6 ] [ 71989-26-9 ] [ 132388-59-1 ] [ 132327-80-1 ] [ 77284-32-3 ] [ 32926-43-5 ] [ 143824-78-6 ] Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine [ No CAS ] Fmoc-Thr(Pg)-OH [ No CAS ] Fmoc-Ser(Pg)-OH [ No CAS ] C153 H233 N43 O47 [ No CAS ] 14 [ 35661-60-0 ] [ 35661-39-3 ] [ 35661-40-6 ] [ 71989-14-5 ] [ 71989-18-9 ] [ 71989-23-6 ] [ 71989-26-9 ] [ 35661-38-2 ] [ 132388-59-1 ] [ 132327-80-1 ] [ 77284-32-3 ] [ 32926-43-5 ] [ 143824-78-6 ] Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine [ No CAS ] Fmoc-Thr(Pg)-OH [ No CAS ] Fmoc-Ser(Pg)-OH [ No CAS ] C152 H234 N42 O48 [ No CAS ] 15 [ 29022-11-5 ] [ 35661-39-3 ] [ 35661-40-6 ] [ 71989-14-5 ] [ 71989-38-3 ] [ 77284-32-3 ] [ 104091-08-9 ] [ 143824-78-6 ] [ 137076-54-1 ] DOTA-DGlu-Ala-Tyr-Gly-Trp-Nle-Asp-Phe-NH<SUB>2</SUB>, Nle=norleucine, DOTA=1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid [ No CAS ] 16 [ 35661-39-3 ] [ 35661-38-2 ] [ 77284-32-3 ] [ 71989-31-6 ] [ 135112-28-6 ] [ 143674-78-6 ] [ 170642-27-0 ] [ 112883-41-7 ] C62 H84 N9 O13 Pol [ No CAS ] 17 [ 35661-38-2 ] [ 77284-32-3 ] [ 71989-31-6 ] [ 135112-28-6 ] [ 143674-78-6 ] [ 170642-27-0 ] [ 112883-41-7 ] C70 H99 N10 O14 Pol [ No CAS ] 18 [ 77284-32-3 ] [ 71989-31-6 ] [ 135112-28-6 ] [ 143674-78-6 ] [ 170642-27-0 ] [ 112883-41-7 ] C71 H102 N9 O13 Pol [ No CAS ] 19 [ 35661-39-3 ] C32 H34 N2 O8 [ No CAS ] [ 35661-40-6 ] [ 71989-14-5 ] [ 108-24-7 ] [ 96402-49-2 ] [ 77284-32-3 ] Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine [ No CAS ] [ 268209-75-2 ] C52 H71 N13 O12 [ No CAS ] 20 [ 3235-69-6 ] [ 159610-93-2 ] C26 H19 N2 O5 Pol [ No CAS ] [ 132684-59-4 ] [ 77284-32-3 ] Mor-Hfe-Ser(Me)-Nle-ACC [ No CAS ] 21 [ 3235-69-6 ] [ 159610-93-2 ] [ 35661-60-0 ] C26 H19 N2 O5 Pol [ No CAS ] [ 77284-32-3 ] Mor-Nle-Ser(Me)-Leu-ACC [ No CAS ]