Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 109425-51-6 | MDL No. : | MFCD00043332 |
Formula : | C40H33N3O4 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | XXMYDXUIZKNHDT-QNGWXLTQSA-N |
M.W : | 619.71 | Pubchem ID : | 11422193 |
Synonyms : |
|
Num. heavy atoms : | 47 |
Num. arom. heavy atoms : | 35 |
Fraction Csp3 : | 0.12 |
Num. rotatable bonds : | 12 |
Num. H-bond acceptors : | 5.0 |
Num. H-bond donors : | 2.0 |
Molar Refractivity : | 180.05 |
TPSA : | 93.45 Ų |
GI absorption : | Low |
BBB permeant : | No |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -4.73 cm/s |
Log Po/w (iLOGP) : | 4.08 |
Log Po/w (XLOGP3) : | 7.54 |
Log Po/w (WLOGP) : | 7.26 |
Log Po/w (MLOGP) : | 4.65 |
Log Po/w (SILICOS-IT) : | 6.48 |
Consensus Log Po/w : | 6.0 |
Lipinski : | 2.0 |
Ghose : | None |
Veber : | 1.0 |
Egan : | 1.0 |
Muegge : | 2.0 |
Bioavailability Score : | 0.17 |
Log S (ESOL) : | -8.19 |
Solubility : | 0.00000399 mg/ml ; 0.0000000064 mol/l |
Class : | Poorly soluble |
Log S (Ali) : | -9.34 |
Solubility : | 0.000000285 mg/ml ; 0.0000000005 mol/l |
Class : | Poorly soluble |
Log S (SILICOS-IT) : | -12.73 |
Solubility : | 0.0000000001 mg/ml ; 0.0 mol/l |
Class : | Insoluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 3.0 |
Synthetic accessibility : | 4.93 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
83% | With piperidine In tetrahydrofuran for 2 h; | Fmoc-His(Trt)-OH 100 g 0.161 mol 1 Eq Piperidine 140 g 1.614 mol 10 EqTHF 2000 ml lOOg Fmoc-His(Trt)-OH are dissolved in 2000 mL THF and treated with 140 g piperidine for 2 h under stirring with a mechanical stirrer blade. TLC indicated complete FMOC removal after that period.Water (approximately 4 L) was added and stirred for another 30 minutes. The precipitate was filtered with suction. The clear filtrate was concentrated to remove all TFfF. The pH was adjusted to 2.5 with dilute HCl and the mixture stirred overnight. Filtration yielded 53 g colorless crystals (83 percent), which were dried in the air overnight. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
General procedure: The solid phase peptide syntheses were performed on a Prelude Peptide Synthesizer (Protein Technologies Inc) using standard Fmoc chemistry and HBTU/DIPEA activation. DMF was used as the solvent. Deprotection: 20percent piperidine/DMF for 2×2.5 min. Washes: 7×DMF. Coupling 2:5:10 200 mM AA/500 mM HBTU/2M DIPEA in DMF 2× for 20 min. Washes: 5×DMF. In cases where a Lys-side-chain was modified, Fmoc-L-Lys(ivDde)-OH was used in the corresponding position. After completion of the synthesis, the ivDde group was removed according to a literature procedure (S. R. Chhabra et al., Tetrahedron Lett. 39, (1998), 1603). The following acylations were carried out by treating the resin with the N-hydroxy succinimide esters of the desired acid or using coupling reagents like HBTU/DIPEA or HOBt/DIC. (0270) All the peptides that had been synthesized were cleaved from the resin with King's cleavage cocktail consisting of 82.5percent TFA, 5percent phenol, 5percent water, 5percent thioanisole, 2.5percent EDT. The crude peptides were then precipitated in diethyl or diisopropyl ether, centrifuged, and lyophilized. Peptides were analyzed by analytical HPLC and checked by ESI mass spectrometry. Crude peptides were purified by a conventional preparative HPLC purification procedure. Example 1 The solid phase synthesis was carried out on Rink-resin with a loading of 0.38 mmol/g, 75-150 mum from the company Agilent Technologies. The Fmoc-synthesis strategy was applied with HBTU/DIPEA-activation. The peptide was cleaved from the resin with King's cocktail (D. S. King, C. G. Fields, G. B. Fields, Int. J. Peptide Protein Res. 36, 1990, 255-266). The crude product was purified via preparative HPLC on a Waters column (XBridge, BEH130, Prep C18, 5 muM) using an acetonitrile/water gradient (both buffers with 0.1percent TFA). (0296) Finally, the molecular mass of the purified peptide was confirmed by LC-MS. M.W. (calculated)=4188.5 g/mol; M.W. (found)=4188.6 g/mol. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Single-Coupling Procedure To the reaction vessel containing resin from the previous step was added piperidine:DMF (20:80 v/v, 2.0mL). The mixture was periodically agitated for 3 minutes and then the solution was drained through the frit.To the reaction vessel was added piperidine:DMF (20:80 v/v, 2.0 mL). The mixture was periodically agitatedfor 3 minutes and then the solution was drained through the frit. The resin washed successively six times asfollows: for each wash, DMF (2.0 mL) was added to top of the vessel (not through the bottom frit) and theresulting mixture was periodically agitated for 30 seconds before the solution was drained through the frit. Tothe reaction vessel was added the amino acid (0.2M in DMF, 1.0 mL, 2 eq), then HATU (0.2M in DMF, 1.0mL, 2 eq), and finally DIPEA (0.4M in DMF, 1.0 mL, 4 eq). The mixture was periodically agitated for 15minutes, then the reaction solution was drained through the frit. The resin washed successively four times asfollows: for each wash, DMF (2.0 mL) was added to top of the vessel (not through the bottom frit) and theresulting mixture was periodically agitated for 30 seconds before the solution was drained through the frit. Tothe reaction vessel was added acetic anhydride (2.0 mL). The mixture was periodically agitated for 10minutes, then the solution was drained through the frit. The resin washed successively four times as follows:for each wash, DMF (2.0 mL) was added to top of the vessel (not through the bottom frit) and the resultingmixture was periodically agitated for 90 seconds before the solution was drained through the frit. Theresulting resin was used directly in the next step. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | The taltirelrin was synthesized by using a core-cell (CS) skillsthat can provide amine function in C-terminal and using CS-Rink Amide MBHA. here using a quantitative method it was measured and 0.8 mmol / g loaded resin was used. The synthesis proceeded on 0.1M scale. Synthesis was performed using the fully automated peptidesynthesizer manufactured by SONATA XT a PTI Company. The removal of Fmoc protector of resin. Fmoc protected core-shell (CS) type Rink Amide MBHA Resin(100mmol, 125g, 0.8 mmol / g, beadTechpvt. ltd.) is inserted in a fully automatic peptide synthesizer SONATA XT 3.2L reaction vessel and thendimethylformamide (DMF ) was added and then inserted into the filtered reactorand and was dilated for 30 minutes.after filtration and removal of DMF, then 20% piperidine (in DMF) was put infiltration reactor and then reacted for 10 minutes and filtered, and again 20%piperidine (in DMF) is put and for reacted for 5 minutes and filtered and Fmocremoved rink Amide MBHA resin was prepared. Filtered and the filtrate discarded and the resin remaining inreactor was washed in the following procedure and then filtered: DMF x 2 times(each 5 min), Dichloromethane x 2 times (each 5 min), DMF x 2 times (each 5min) Fmoc-Pro-OH coupling After the Fmoc-Pro-OH 3equivalents was dissolved in DMF, then matching the amino acid equivalent DIC(N, N'-Diisopropylcarbodiimide) and HOBt Cl- (1-Hydroxy-6-Chlorobenzotriazole)is inserted and for about 5 minutes it is activated and inserted in a Fmocprotector removed CS-Rink Amide MBHA resin inserted filteration reactor andthen reacted for 3 hours. After the reaction was completed the reaction solution wasfiltered and the remaining Fmoc-Pro-CS-Rink Amide MBHA resin in the filtrationreactor was washed in the following order: DMF x 2 times (each 5 min),dichloromethane x 2 times ( each 5 min), DMF x 2 times (each 5 min).The reaction termination was confirmed by the color reaction(Kaiser Test). Removal of the Fmoc protector of Fmoc-Pro-CS-Rink Amide Resin In a washed Fmoc-Pro-Rink Amide MBHA resin inserted reactor 20%piperidine (in DMF) is inserted and reacted for 20 minutes and filtered, andagain 20% piperidine (in DMF) is put and for10 minutes It was reacted and then filtered to prepare Fmoc removed H-Pro-CS-Rink Amide MBHA resin. After filtration H-Pro-CS-Rink Amide MBHA resin remaining in thereactor is then washed in following order and then filtered: DMF x 2 times(each 5 min), Dichloromethane x 2 times (each 5 min), DMF x 2 times (each 5min) Fmoc-His (Trt) -OH coupling Fmoc-His (Trt) -OH 3 equivalent after dissolved in DMF, inquantity equivalent of the amino acid DIC and HOBt-Cl is put in and for about 5minutes it is actively refluxed and, then placed in a H-Pro-Rink Amide resininserted filtration reactor and reaction was carried out for 3 hours. After the reaction was completed the reaction solution wasfiltered and the remaining Fmoc-Pro-CS-Rink Amide MBHA resin in the filtrationreactor was washed in the following order: DMF x 2 times (each 5 min),dichloromethane x 2 times ( each 5 min), DMF x 2 times (each 5 min). The reaction termination was confirmed by the color reaction(Kaiser Test). Separation of the peptides from the resin In a Well-dried 1-methyl-4,5-dihydro-orotic acid -His (Trt)-Pro-CS-Rink Amide Resin inserted filtration reactor 10 times volume of resincutting solution (95% TFA, 2.5% TIS,2.5% H2O) is carefully added and reaction was carried out for 3 hours. After completion ethanol10 times the volume of the reaction filtrate is poured and the peptide isextracted. The peptide extracted to remove ethanol is precipitated using acentrifugal separator, and then using two more times ethanol and from the TFAresidue amino acid side chain protectoron removing of residue matter it is dried to yield 36.5g title compound (90%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75% | Fmoc strategy based solid phase peptide synthesis procedure was employed for preparing the non-targeting control SNEHPSDK-lipopeptide 2 as depicted schematically in Scheme 2. 500 mg of H-Eys(l3oc)-2-ClTrt resin-i (M-Soc-Eysine pre-loaded 2-chioro trityl resin, 0.77-0.79 mmol/g loading) was first swelled in 10 mE DMF for 3 hand then coupled with Fmoc-Asp(O-tert-butyl) (2 equiv) using HETU (2 equiv) and DIPEA (4 equiv) in 10 mE DMF at room temperature for 1 .5 h to afford intermediate 2 (Scheme 2). The resin was washed with 10 mE DMF and the Fmoc group was removed with a solution of piperidine:DMF (1:4, v/v, 10 mE, 5 mi 2x) at room temperature. Following the same Fmoc strategy, sequential couplings of Fmoc-Ser(Otert-butyl)-OH, Fmoc-Pro-OH, Fmoc-His(Trt)-OH, FmocEcu-OH, Fmoc-Asn(Trt)-OH and l3oc-Ser(O-tert-butyl)-OH (2 equiv each) using HETU (2 equiv) and DIPEA (4 equiv) in DMF at room temperature for 1 .5 h for each amino acid afforded the resin associated octapeptide intermediate 3 (Scheme 2). The resin-bound octapeptide intermediate 3 (Scheme 2) was taken out of the reaction vessel in 10 mE DCM, washed thoroughly with DCM (5x10 mE) and dried well. The resulting dried resin bound intermediate 3 (Scheme 2) was treated with TFA:DCM (5:95, v/v, 100 mE) for 2 hat 0° C. to obtain a protected octapeptide intermediate 4 (0.37 g, 75percent yield). N, N-di-n-octadecyl-N-2-aminoeth- ylamine (0.08 g, 0.15 mmol) was then dissolved in 3 mE dry DCM and the solution was added to an ice cold reaction mixture which has been under stirring for 30 mm containing EDCI (0.043 g, 0.23 mmol), HOST (0.034 g, 0.23 mmol), DIPEA (131 pL, 0.75 mmol) and the protected octapeptide intermediate 4 (0.33 g, 0.19 mmol) in dry DCM (5 mE). The resulting solution was lefi under stirring at room temperature for 12 h. The solvent was then evaporated in the rotary evaporator at 30° C. and the residue was dried completely under high vacuum. The dried intermediate was treated with TFA:DCM:TIS (90:5:5 v/v, 2 mE) for 3 h at 0° C. and washed with TFA:DCM (1:9, v/v, 10 mE). The acid washings were concentrated to about 1 mE and 14 mE acetone was added until a white precipitate separated. Same precipitation process was repeated five times with 14 mE acetone each time and the final precipitate was washed two times with 14 mE of dietheylether each time. The precipitate upon chloride ion exchange chromatography over 5 g Amberlyst IRA-400 resin followed by purification with reversed phase HPEC afforded the pure SNEHPSDK-lipopeptide 2 as a white, solid (188 mg, 47percent yield based on octapeptide intermediate 4 shown in Scheme 2). The purified SNEHPSDK-lipopeptide 2 was characterized by the molecular ion peak in ESIMS and purity was confirmed by reversed phase analytical HPEC using two different mobile phases. ESIMS: mlz=1444 [M+1]+ |
Tags: 109425-51-6 synthesis path| 109425-51-6 SDS| 109425-51-6 COA| 109425-51-6 purity| 109425-51-6 application| 109425-51-6 NMR| 109425-51-6 COA| 109425-51-6 structure
[ 135610-90-1 ]
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanoic acid
Similarity: 1.00
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :