2,2'-bithiophene-Thiophenes| Ambeed

: Acylation: The piperidine nitrogen can be acylated with various acyl chlorides or anhydrides to introduce new substituents on the amide nitrogen. Friedel-Crafts Acylation: If you have an appropriate aromatic compound, you can perform a Friedel-Crafts acylation reaction to attach an acyl group to the phenyl ring. This can be done using Lewis acids like aluminum chloride (AlCl₃) as a catalyst. Grignard Reaction: You can react (S)-N-phenylpiperidine-2-carboxamide with a Grignard reagent (RMgX), where R is an alkyl or aryl group. This reaction can be used to form new carbon-carbon bonds. Amide Coupling: (S)-N-phenylpiperidine-2-carboxamide can be coupled with other molecules using amide coupling agents like EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide) to form amide bonds. Nucleophilic Substitution: The piperidine ring can undergo nucleophilic substitution reactions, particularly if the piperidine nitrogen is activated. For example, it can react with alkyl halides to form N-alkylated products. Reductive Amination: By reacting with an appropriate aldehyde or ketone in the presence of reducing agents like sodium cyanoborohydride (NaBH₃CN), you can perform reductive amination to introduce new substituents on the piperidine nitrogen. Hofmann Degradation: Treating the amide with sodium hypochlorite (NaOCl) and sodium hydroxide (NaOH) can result in the Hofmann degradation, leading to the formation of the corresponding primary amine.

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