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Benzenamine, 4-[(2-chloro-4-pyridinyl)oxy]-2,5-difluoro-
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[ CAS No. 1225278-65-8 ] Benzenamine, 4-[(2-chloro-4-pyridinyl)oxy]-2,5-difluoro-

Cat. No.: A989405
Chemical Structure| 1225278-65-8
Chemical Structure| 1225278-65-8
 Structure of 1225278-65-8
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CAS No. :1225278-65-8 MDL No. :MFCD26961015
Formula : C11H7ClF2N2O Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 256.64 Pubchem ID :-
Synonyms :

Safety of [ 1225278-65-8 ]

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Application In Synthesis of [ 1225278-65-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1225278-65-8 ]

[ 1225278-65-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1052114-81-4 ]
  • [ 1225278-65-8 ]
  • N-(2,5-difluoro-4-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)phenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide [ No CAS ]
Reference： [1]Patent: WO2014/145004,2014,A1
  • 2
  • [ 1052114-81-4 ]
  • [ 1225278-65-8 ]
  • N-(4-((2-chloropyridin-4-yl)oxy)-2,5-difluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
54% With 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20℃; Example 10: A mixture of Example A8 (0.363 g, 1.559 mmol), Example Al (0.200 g, 0.779 mmol), and TBTU (0.751 g, 2.338 mmol) in DMF (15 mL) was treated with Et3N (0.652 mL, 4.68 mmol) and stirred at RT overnight. The mixture was treated with brine, extracted with EtOAc (2x) and the combined organics were washed successively with 5% citric acid (2x), satd. NaHCO3 (ix), 5% LiC1 (ix), and brine (ix), dried over Mg504, concentrated to dryness and purified via silica gel chromatography (EtOAc/Hex). The resulting material was treated with 4:1 MeCN/H20, the solid collected via filtration and driedafford N-(4-((2-chloropyridin-4-yl)oxy)-2,5-difluorophenyl)-5 -(4-fluorophenyl)-4-oxo- 1,4- dihydropyridine-3-carboxamide (200 mg, 54%) as a white solid. ?H NMR (400 MHz, DMSO-d6): oe 13.48 (s, 1 H), 12.72 (s, 1 H), 8.60-8.58 (m, 2 H), 8.30 (d, J = 5.3 Hz, 1 H), 8.09 (s, 1 H), 7.67-7.65 (m, 3 H), 7.26-7.23 (m, 2 H), 7.17 (s, 1 H), 7.06 (s, 1 H); MS (ESI) mlz: 472.0 (M+Hj.
Reference： [1]Patent: WO2014/145004,2014,A1 .Location in patent: Paragraph 0119

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