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[ CAS No. 56287-72-0 ] 2-(2-Fluoroacetamido)-5-nitro-N-(o-tolyl)benzamide

Cat. No.: A200451
Chemical Structure| 56287-72-0
Chemical Structure| 56287-72-0
Structure of 56287-72-0 * Storage: Sealed in dry,2-8°C

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Product Details of [ 56287-72-0 ]

CAS No. :56287-72-0 MDL No. :MFCD11977266
Formula : C16H14FN3O4 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 331.30 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 56287-72-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 56287-72-0 ]

[ 56287-72-0 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 56287-72-0 ]
  • [ 56287-73-1 ]
YieldReaction ConditionsOperation in experiment
98.7% With acetic anhydride In acetic acid 16.5 g(0.05 mol) of N-(2-fluoroacetamido-5-nitrobenzoyl)-o-toluidine and 25.5 g(0.25 mol) of acetic acid anhydride are dissolved in 250 ml of glacial acetic acid.
The solution is refluxed for 2 hours under heating.
Then, the reaction solution is evaporated to remove solvent.
The residue thus obtained is poured into ice-water, and the aqueous mixture is adjusted to pH 9 with potassium carbonate.
The crystalline precipitate is collected by filtration. 15.5 g of 2-fluoromethyl-3-(o-tolyl)-6-nitro-4(3H)-quinazolinone are obtained.
Yield: 98.7 percent; M.p. 155°-158°C(recrystallized from ethanol).
Infrared absorption spectrum: νmax.liquid paraffin (cm-1): 1705, 1610, 1588,
Nuclear magnetic resonance spectrum: δ in CDCl3: 2.14(s, 3H), 4.96(d, 2H, J, = 47 HZ), 7.05-9.20(m, 7H)
Reference: [1] Patent: US3966731, 1976, A,
[2] Patent: US3966731, 1976, A,
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