Purity | Size | Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity |
95+% | 1g | $158.00 | Inquiry | Inquiry |
CAS No. : | 56287-72-0 | MDL No. : | MFCD11977266 |
Formula : | C16H14FN3O4 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 331.30 | Pubchem ID : | - |
Synonyms : |
Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98.7% | With acetic anhydride In acetic acid | 16.5 g(0.05 mol) of N-(2-fluoroacetamido-5-nitrobenzoyl)-o-toluidine and 25.5 g(0.25 mol) of acetic acid anhydride are dissolved in 250 ml of glacial acetic acid. The solution is refluxed for 2 hours under heating. Then, the reaction solution is evaporated to remove solvent. The residue thus obtained is poured into ice-water, and the aqueous mixture is adjusted to pH 9 with potassium carbonate. The crystalline precipitate is collected by filtration. 15.5 g of 2-fluoromethyl-3-(o-tolyl)-6-nitro-4(3H)-quinazolinone are obtained. Yield: 98.7 percent; M.p. 155°-158°C(recrystallized from ethanol). Infrared absorption spectrum: νmax.liquid paraffin (cm-1): 1705, 1610, 1588, Nuclear magnetic resonance spectrum: δ in CDCl3: 2.14(s, 3H), 4.96(d, 2H, J, = 47 HZ), 7.05-9.20(m, 7H) |