[ CAS No. 56-95-1 ] Chlorhexidine Diacetate

Cat. No.: A178012

2D 3D

Structure of 56-95-1 * Storage: Sealed in dry,Room Temperature

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Quality Control of [ 56-95-1 ]

COA NMR CNMR HPLC LC-MS

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Specification

Alternatived Products of [ 56-95-1 ]

Product Details of [ 56-95-1 ]

CAS No. :	56-95-1	MDL No. :	MFCD00012532
Formula :	C₂₆H₃₈Cl₂N₁₀O₄	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	WDRFFJWBUDTUCA-UHFFFAOYSA-N
M.W :	625.55	Pubchem ID :	9562059
Synonyms :	Hibitane diacetate	Chemical Name :	1,1'-Hexamethylenebis[5-(p-chlorophenyl)biguanide] diacetate

Safety of [ 56-95-1 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 56-95-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 56-95-1 ]

[ 56-95-1 ] Synthesis Path-Downstream 1~19

2
[ 56-95-1 ]
chlorhexidine dihydrate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium hydroxide; In water; at 50℃;pH 11.0;Product distribution / selectivity;	Chlorhexidine (C22H30N10Cl2), obtained commercially, was reacted with sodium hydroxide to form chlorhexidine dihydrate (C22H30N10Cl2.1.3H2O). Approximately 100 g of a starting material <strong>[56-95-1]chlorhexidine diacetate</strong> was dissolved in 1300 mL of warm deionized water at approximately 50 C. 6 M potassium hydroxide (KOH) was added drop-wise with stirring. A precipitate formed immediately and continued to form upon addition of base until the solution reached a pH of 11. The precipitate was filtered and washed six times with warm, 50 C., deionized water, and then dried in an oven at 60 C. to produce approximately 78 g of chlorhexidine dihydrate. These compounds were analyzed using energy dispersive x-ray spectroscopy (EDX), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and proton nuclear magnetic resonance (1H NMR),EDXChlorhexidine and chlorhexidine dihydrate were analyzed using EDX, a technique well known to those of skill in the art. Table 1 provides both the theoretical and actual elemental composition of chlorhexidine and chlorhexidine dihydrate obtained from the EDX analysis.; FTIRFTIR was used to compare the characteristic peaks of different functional groups in chlorhexidine dihydrate and chlorhexidine. Chlorhexidine had peaks at 3513, 3473, 3410, 3371 cm-1, characteristic of N-H stretching, and peaks at 1635 and 1595 cm-1, characteristic of aromatic and aliphatic guanidine absorptions (ArNHC(N-H)NHAr) and ((CH3)2NC(N-H)C(CH3)2). The chlorhexidine dihydrate spectrum of FIG. 3 had peaks at 3458 and 3406 cm-1, characteristic of N-H stretching. The decreased frequencies likely were attributable to hydrogen bonding. The chlorhexidine dihydrate spectrum also had a broad band between 3300-2850 cm-1 that was characteristic of an intermolecular OH hydrogen-bonded bridge (typically appearing between 3405 and 2936 cm-1). Chlorhexidine dihydrate also had the aromatic guanadine peak at 1605 cm-1. The decreased frequency, again, likely was attributable to hydrogen bonding.TGATGA was used to determine the moisture content of chlorhexidine base (FIG. 4) and chlorhexidine dehydrate (FIG. 5). As shown by the derivative weight loss curve of FIG. 5, there was a loss of a small molecule (presumably water) at 100 C. and a mass decrease of 4.700% at 120.07 C. for chlorhexidine dihydrate. The mass loss likely corresponded to the 3.98% water present in the chlorhexidine dihydrate.1H NMRProton nuclear magnetic resonance (1H NMR) spectroscopy was used to analyze the structure of chlorhexidine dihydrate. The 1H NMR spectrum of chlorhexidine (FIG. 6) had peaks at 8.5, 7.25, 7.0, 3.3, 3.15, 1.9, 1.6, 1.4, and 1.25 ppm. The 1H NMR spectrum of chlorhexidine dihydrate (FIG. 7) had peaks at 8.5, 7.2, 6.9, 3.3, 3.15, 1.85, 1.6, 1.35, and 1.25 ppm, similar to that of chlorhexidine. The intensities, however, were different. Specifically, the peak at 8.5 ppm was significantly less intense in the chlorhexidine dihydrate spectrum. The peaks at 8.5, 1.85, and 1.35 ppm showed no spin-spin coupling and were therefore in rapid equilibrium in the deuterated methanol solvent (tautomerization). The water appeared to preferentially stabilize some of the tautomers of chlorhexidine.

Reference： [1]Patent: US2008/26025,2008,A1 .Location in patent: Page/Page column 8

3
[ 56-95-1 ]
[ 55-56-1 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium hydroxide; In water; at 50℃;pH 11.0;	Commercially obtained chlorhexidine (C22H30N10Cl2), obtained commercially, was reacted with sodium hydroxide to form chlorhexidine hydrate. Approximately 100 g of a starting material <strong>[56-95-1]chlorhexidine diacetate</strong> was dissolved in 1300 ml of warm deionized water at approximately 50 C. 6 M potassium hydroxide (KOH) was added drop-wise with stirring. A precipitate formed immediately and continued to form upon addition of base until the solution reached a pH of 11. The precipitate was filtered and washed six times with warm, 50 C., deionized water, and then dried in an oven at 60 C. to produce approximately 78 g of chlorhexidine hydrate.The chlorhexidine hydrate has a theoretical formulation of C22H30N10Cl2.nH2O. In multiple production runs, the chlorhexidine hydrate product was determined to have an actual degree of hydration (n) of about 1.4.

Reference： [1]Patent: US2009/191250,2009,A1 .Location in patent: Page/Page column 10

4
copper(II) choride dihydrate [ No CAS ]
[ 64-17-5 ]
[ 56-95-1 ]
C₂₂H₃₀Cl₆Cu₂N₁₀*2C₂H₆O [ No CAS ]

Reference： [1]Journal of Thermal Analysis and Calorimetry,2013,vol. 111,p. 1189 - 1195

5
[ 64-17-5 ]
[ 56-95-1 ]
[ 7789-45-9 ]
C₂₂H₃₀Br₄Cl₂Cu₂N₁₀*2C₂H₆O [ No CAS ]

Reference： [1]Journal of Thermal Analysis and Calorimetry,2013,vol. 111,p. 1189 - 1195

6
[ 64-17-5 ]
[ 6046-93-1 ]
[ 56-95-1 ]
C₂₂H₃₀Cl₂CuN₁₀⁽²⁺⁾*2C₂H₃O₂^(1-)*C₂H₆O [ No CAS ]

Reference： [1]Journal of Thermal Analysis and Calorimetry,2013,vol. 111,p. 1189 - 1195

7
[ 64-17-5 ]
[ 6046-93-1 ]
[ 56-95-1 ]
C₂₆H₃₆Cl₂Cu₂N₁₀O₄⁽²⁺⁾*2C₂H₃O₂^(1-)*2C₂H₆O [ No CAS ]

Reference： [1]Journal of Thermal Analysis and Calorimetry,2013,vol. 111,p. 1189 - 1195

8
copper(II) choride dihydrate [ No CAS ]
[ 56-95-1 ]
C₂₂H₃₀Cl₄CuN₁₀*2H₂O [ No CAS ]

Reference： [1]Journal of Thermal Analysis and Calorimetry,2013,vol. 111,p. 1189 - 1195

9
[ 56-95-1 ]
[ 7789-45-9 ]
C₂₂H₃₀Br₂Cl₂CuN₁₀*1.5H₂O [ No CAS ]

Reference： [1]Journal of Thermal Analysis and Calorimetry,2013,vol. 111,p. 1189 - 1195

10
[ 56-95-1 ]
[ 4800-94-6 ]
chlorhexidine carbenicillin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
93%	In water; butan-1-ol; at 20℃; for 48.0h;	General procedure: The synthesis and physical characterization of four beta-lactam-based chlorhexidine GUMBOS, namely chlorhexidine di-ampicillin, chlorhexidine carbenicillin, chlorhexidine di-cephalothin and chlorhexidinedi-oxacillin, were performed using methods previously reported by Cole et al. (2013) [24], but with slight modification. Briefly, stoichiometric amounts of <strong>[56-95-1]chlorhexidine diacetate</strong> and beta-lactam antibiotic, with the latter in slight excess, was stirred for 48 h at room temperature in a butanol:water (1:1) mixture to ensure the complete formation of the beta-lactam-based chlorhexidine GUMBOS. After removing butanol from the GUMBOS products, they were purified by washing several times with cold deionized water and dried overnight with a high vacuum. The structures of chlorhexidine di-ampicillin, chlorhexidine carbenicillin, chlorhexidine di-oxacillin and chlorhexidine di-cephalothin (Figure 1) were mainly confirmed by NMR, mass spectrometry and elemental analysis, among other spectroscopic data.

Reference： [1]Molecules,2015,vol. 20,p. 6466 - 6487

11
[ 56-95-1 ]
[ 58-71-9 ]
chlorhexidine dicephalothin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
83%	In water; butan-1-ol; at 20℃; for 48.0h;	General procedure: The synthesis and physical characterization of four beta-lactam-based chlorhexidine GUMBOS, namely chlorhexidine di-ampicillin, chlorhexidine carbenicillin, chlorhexidine di-cephalothin and chlorhexidinedi-oxacillin, were performed using methods previously reported by Cole et al. (2013) [24], but with slight modification. Briefly, stoichiometric amounts of <strong>[56-95-1]chlorhexidine diacetate</strong> and beta-lactam antibiotic, with the latter in slight excess, was stirred for 48 h at room temperature in a butanol:water (1:1) mixture to ensure the complete formation of the beta-lactam-based chlorhexidine GUMBOS. After removing butanol from the GUMBOS products, they were purified by washing several times with cold deionized water and dried overnight with a high vacuum. The structures of chlorhexidine di-ampicillin, chlorhexidine carbenicillin, chlorhexidine di-oxacillin and chlorhexidine di-cephalothin (Figure 1) were mainly confirmed by NMR, mass spectrometry and elemental analysis, among other spectroscopic data.

Reference： [1]Molecules,2015,vol. 20,p. 6466 - 6487

12
[ 56-95-1 ]
[ 1173-88-2 ]
chlorhexidine dioxacillin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85%	In water; butan-1-ol; at 20℃; for 48.0h;	General procedure: The synthesis and physical characterization of four beta-lactam-based chlorhexidine GUMBOS, namely chlorhexidine di-ampicillin, chlorhexidine carbenicillin, chlorhexidine di-cephalothin and chlorhexidinedi-oxacillin, were performed using methods previously reported by Cole et al. (2013) [24], but with slight modification. Briefly, stoichiometric amounts of <strong>[56-95-1]chlorhexidine diacetate</strong> and beta-lactam antibiotic, with the latter in slight excess, was stirred for 48 h at room temperature in a butanol:water (1:1) mixture to ensure the complete formation of the beta-lactam-based chlorhexidine GUMBOS. After removing butanol from the GUMBOS products, they were purified by washing several times with cold deionized water and dried overnight with a high vacuum. The structures of chlorhexidine di-ampicillin, chlorhexidine carbenicillin, chlorhexidine di-oxacillin and chlorhexidine di-cephalothin (Figure 1) were mainly confirmed by NMR, mass spectrometry and elemental analysis, among other spectroscopic data.

Reference： [1]Molecules,2015,vol. 20,p. 6466 - 6487

13
[ 56-95-1 ]
[ 69-52-3 ]
chlorhexidine diampicillin [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
98%	In water; butan-1-ol; at 20℃; for 48.0h;	General procedure: The synthesis and physical characterization of four beta-lactam-based chlorhexidine GUMBOS, namely chlorhexidine di-ampicillin, chlorhexidine carbenicillin, chlorhexidine di-cephalothin and chlorhexidinedi-oxacillin, were performed using methods previously reported by Cole et al. (2013) [24], but with slight modification. Briefly, stoichiometric amounts of <strong>[56-95-1]chlorhexidine diacetate</strong> and beta-lactam antibiotic, with the latter in slight excess, was stirred for 48 h at room temperature in a butanol:water (1:1) mixture to ensure the complete formation of the beta-lactam-based chlorhexidine GUMBOS. After removing butanol from the GUMBOS products, they were purified by washing several times with cold deionized water and dried overnight with a high vacuum. The structures of chlorhexidine di-ampicillin, chlorhexidine carbenicillin, chlorhexidine di-oxacillin and chlorhexidine di-cephalothin (Figure 1) were mainly confirmed by NMR, mass spectrometry and elemental analysis, among other spectroscopic data. Chlorhexidine di-ampicillin. Off-White Solid, yield 98%, Water solubility: 126 mug/mL. Solubilityproduct constant (Ksp): 4.63 × 10-12 M3. 1H-NMR (400 Hz, DMSO-d6) delta 8.58-8.36 (m, 2 H) 7.21-7.50(m, 18 H), 5.08 (d, J = 2.74 Hz, 2 H), 4.96 (s, 4 H), 3.69 (d, J = 3.13 Hz, 2 H), 3.26 (s, 2 H), 3.07 (dt,J = 7.04, 6.65 Hz, 4 H), 1.85 (s, 4 H), 1.57 (s, 6 H), 1.49 (s, 4 H), 1.46 (quin, 4 H), 1.44 (s, 4 H), 1.27(quin, 4 H), 1.17 (s, 6 H), 1.15 (s, 2 H). 13C-NMR (101 MHz, DMSO) delta 180.88, 72.88, 172.36, 166.94,166.76, 139.07, 128.24, 127.01-128.43, 121.90, 76.07, 68.38, 60.80, 60.01, 58.64, 27.38, 26.76, 25.97.Anal. calcd. for C54H68Cl2N16O8S2: C, 53.86; H, 5.69; Cl, 5.89; N, 18.61; O, 10.63; S, 5.33. Found: C,53.22; H, 5.81; Cl, 5.56; N, 18.37; S, 5.16. HRMS (ESI) m/z calcd. for C54H68Cl2N16O8S2, [M+H+],1203.4424; found, 1203.4136.

Reference： [1]Molecules,2015,vol. 20,p. 6466 - 6487

14
nickel(II) chloride hexahydrate [ No CAS ]
[ 56-95-1 ]
[Ni(chlorhexidine)]Cl₂*2H₂O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In ethanol; for 2.0h;Heating;	General procedure: The nickel(II) complexes, chlorhexidinenickel(II) chloride dihydrate (complex 1), chlorhexidinenickel(II) bromide dihydrate (complex 2) and chlorhexidinenickel(II) acetate ethanolate(complex 3), were prepared by the following general method. <strong>[56-95-1]Chlorhexidine diacetate</strong>monohydrate, 0.6435 g (1 mmol), was dissolved in 30 mL ethanol, under slight heating. Therequired solid metal salt, i.e., NiCl2·6H2O (0.2377 g, 1.0 mmol for complex 1), NiBr2·(0.2185g, 1.0 mmol for complex 2) and Ni(CH3COO)2·4H2O (0.2486 g, 1.0 mmol for complex 3),was added slowly under stirring, keeping the temperature below 40 C. The color of thesolutions became orange after a few minutes. The precipitate began to form after 2 h of stirringwith heating. The mixture was left overnight and then the orange precipitate was filteredoff, washed with ethanol and dried under air.

Reference： [1]Journal of the Serbian Chemical Society,2018,vol. 83,p. 271 - 284

15
[ 56-95-1 ]
nickel dibromide [ No CAS ]
[Ni(chlorhexidine)]Br₂*2H₂O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In ethanol; for 2.0h;Heating;	General procedure: The nickel(II) complexes, chlorhexidinenickel(II) chloride dihydrate (complex 1), chlorhexidinenickel(II) bromide dihydrate (complex 2) and chlorhexidinenickel(II) acetate ethanolate(complex 3), were prepared by the following general method. <strong>[56-95-1]Chlorhexidine diacetate</strong>monohydrate, 0.6435 g (1 mmol), was dissolved in 30 mL ethanol, under slight heating. Therequired solid metal salt, i.e., NiCl2·6H2O (0.2377 g, 1.0 mmol for complex 1), NiBr2·(0.2185g, 1.0 mmol for complex 2) and Ni(CH3COO)2·4H2O (0.2486 g, 1.0 mmol for complex 3),was added slowly under stirring, keeping the temperature below 40 C. The color of thesolutions became orange after a few minutes. The precipitate began to form after 2 h of stirringwith heating. The mixture was left overnight and then the orange precipitate was filteredoff, washed with ethanol and dried under air.

Reference： [1]Journal of the Serbian Chemical Society,2018,vol. 83,p. 271 - 284

16
[ 64-17-5 ]
[ 6018-89-9 ]
[ 56-95-1 ]
[Ni(chlorhexidine)](CH₃COO)₂*C₂H₅OH [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	for 2.0h;Heating;	General procedure: The nickel(II) complexes, chlorhexidinenickel(II) chloride dihydrate (complex 1), chlorhexidinenickel(II) bromide dihydrate (complex 2) and chlorhexidinenickel(II) acetate ethanolate(complex 3), were prepared by the following general method. <strong>[56-95-1]Chlorhexidine diacetate</strong>monohydrate, 0.6435 g (1 mmol), was dissolved in 30 mL ethanol, under slight heating. Therequired solid metal salt, i.e., NiCl2·6H2O (0.2377 g, 1.0 mmol for complex 1), NiBr2·(0.2185g, 1.0 mmol for complex 2) and Ni(CH3COO)2·4H2O (0.2486 g, 1.0 mmol for complex 3),was added slowly under stirring, keeping the temperature below 40 C. The color of thesolutions became orange after a few minutes. The precipitate began to form after 2 h of stirringwith heating. The mixture was left overnight and then the orange precipitate was filteredoff, washed with ethanol and dried under air.

Reference： [1]Journal of the Serbian Chemical Society,2018,vol. 83,p. 271 - 284

17
[ 56-95-1 ]
palladium dichloride [ No CAS ]
chlorhexidinepalladium(II) tetrachloridopalladate(II) dihydrate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In ethanol; acetonitrile; at 20℃; for 2.0h;	General procedure: The palladium(II) complexes, chlorhexidinepalladium(II) tetrachloridopalladate(II) dihydrate(complex 4) and chlorhexidinepalladium(II) acetate (complex 5), were obtained by mixinga solution of PdCl2 dissolved in acetonitrile with a solution of chlorhexidine dissolved inethanol, using a 2:1 metal:ligand mole ratio for complex 4 and a 1:1 mole ratio for complex 5.Complex 4 was prepared by adding an ethanolic solution of <strong>[56-95-1]chlorhexidine diacetate</strong> monohydrate(0.6435 g, 1.0 mmol, in 30 mL ethanol) to a refluxing solution containing 0.3546 g(2.0 mmol) of PdCl2 dissolved in acetonitrile. The resulting suspension that was immediatelyformed was stirred at room temperature for 2 h and then filtered under vacuum. The orangeprecipitate was washed with ethanol and dried under air. Complex 5, orange, was obtained inthe same way as complex 4, but using a 1:1 metal:ligand mole ratio, by mixing 0.6435 g (1.0mmol) of ligand dissolved in 30 mL ethanol and 0.1773 g (1.0 mmol) of PdCl2 in acetonitrile.

Reference： [1]Journal of the Serbian Chemical Society,2018,vol. 83,p. 271 - 284

18
[ 56-95-1 ]
palladium dichloride [ No CAS ]
[Pd(chlorhexidine)](CH₃COO)₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In ethanol; acetonitrile; at 20℃; for 2.0h;	General procedure: The palladium(II) complexes, chlorhexidinepalladium(II) tetrachloridopalladate(II) dihydrate(complex 4) and chlorhexidinepalladium(II) acetate (complex 5), were obtained by mixinga solution of PdCl2 dissolved in acetonitrile with a solution of chlorhexidine dissolved inethanol, using a 2:1 metal:ligand mole ratio for complex 4 and a 1:1 mole ratio for complex 5.Complex 4 was prepared by adding an ethanolic solution of <strong>[56-95-1]chlorhexidine diacetate</strong> monohydrate(0.6435 g, 1.0 mmol, in 30 mL ethanol) to a refluxing solution containing 0.3546 g(2.0 mmol) of PdCl2 dissolved in acetonitrile. The resulting suspension that was immediatelyformed was stirred at room temperature for 2 h and then filtered under vacuum. The orangeprecipitate was washed with ethanol and dried under air. Complex 5, orange, was obtained inthe same way as complex 4, but using a 1:1 metal:ligand mole ratio, by mixing 0.6435 g (1.0mmol) of ligand dissolved in 30 mL ethanol and 0.1773 g (1.0 mmol) of PdCl2 in acetonitrile.

Reference： [1]Journal of the Serbian Chemical Society,2018,vol. 83,p. 271 - 284

19
chromium(III) chloride hexahydrate [ No CAS ]
[ 56-95-1 ]
dichloridochlorhexidinechromium(III) acetate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In ethanol; at 40 - 50℃; for 1.0h;	General procedure: The chromium(III) complex, dichloridochlorhexidinechromium(III) acetate (complex 6)was prepared by adding a solution of CrCl36H2O (0.266 g, 1.0 mmol) in ethanol to a solutionof chlorhexidine ligand in ethanol (0.6435 g, 1.0 mmol) and the reaction mixture was heatedat 40-50 C, under constant stirring, for 1 h. The light blue precipitate obtained was separatedby filtration under vacuum, washed with ethanol and dried under air.

Reference： [1]Journal of the Serbian Chemical Society,2018,vol. 83,p. 271 - 284

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P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 56-95-1 ] Chlorhexidine Diacetate

Quality Control of [ 56-95-1 ]

Related Doc. of [ 56-95-1 ]

Product Details of [ 56-95-1 ]

Safety of [ 56-95-1 ]

Application In Synthesis of [ 56-95-1 ]

[ 56-95-1 ] Synthesis Path-Downstream 1~19

Technical Information

Related Functional Groups of [ 56-95-1 ]

Aryls

Chlorides

Amines

Related Parent Nucleus of [ 56-95-1 ]

Guanidines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 56-95-1 ]

Related Parent Nucleus of
[ 56-95-1 ]