CAS No. : | 54718-39-7 | MDL No. : | MFCD02070018 |
Formula : | C6H2Cl3NO2 | Boiling Point : | No data available |
Linear Structure Formula : | - | InChI Key : | XMJRZCYSCMZVJQ-UHFFFAOYSA-N |
M.W : | 226.44 | Pubchem ID : | 4190038 |
Synonyms : |
Signal Word: | Warning | Class: | |
Precautionary Statements: | P261-P280-P305+P351+P338 | UN#: | |
Hazard Statements: | H302-H315-H319-H332-H335 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
To a solution of <strong>[135124-71-9]5-(hydroxymethyl)nicotinonitrile</strong> (1.51 g, 9.7 mmol, 1 equiv) in THF (10 mL) at0 C was added NaH (292 mg, 12.2 mmol, 1.25 equiv). After an additional 20 minutes of stirring theslurry was added to a stirred solution of 2,5,6-trichloronicotinic acid (2.2 g, 9.7 mmol, 1 equiv) in THF at0 C. The solution was slowly allowed to warm to room temperature and stirred for 1 hour. The reactionmixture was then acidified with 1 M HC1 and the precipitated 5,6-dichloro-2-((5-cyanopyridin-3-yl)methoxy)nicotinic acid was collected by vacuum filtration. |
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