Alternatived Products of [ 104870-56-6 ] Product Details of [ 104870-56-6 ]
CAS No. : | 104870-56-6 | MDL No. : | |
Formula : |
C10H18O
| Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : |
154.25
| Pubchem ID : | - |
Synonyms : | |
Safety of [ 104870-56-6 ]
Signal Word: | | Class: | |
Precautionary Statements: | | UN#: | |
Hazard Statements: | | Packing Group: | |
Application In Synthesis of [ 104870-56-6 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 104870-56-6 ]
- 1
- [ 5779-93-1 ]
- [ 104870-56-6 ]
- (2S,4aR,7S,8aS)-2-(2,3-dimethylphenyl)-7-methyl-4-methyleneoctahydro-2H-chromene [ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
58% | With boron trifluoride diethyl etherate; In dichloromethane; at 0℃; for 12h;Inert atmosphere; Cooling; | General procedure: To a solution of isopulegol [(+)-2 or (-)-2 (500 mg, 3.24 mmol)] in anhydrous dicholoromethane (15 mL), a solution of substituted benzaldehydes (1.1 equiv.) in anhydrous dichloromethane (10 mL) was added and cooledto 0°C under argon. To the resulting cold solution, BF3.Et2O (0.162 mmol) was added dropwise and continuedstirring. The progress of the reaction was monitored by TLC. After completion, the reaction mixture was quenched with saturated sodium bicarbonate (20 mL) and extracted with dichloromethane (3 x 15 mL). The combined organic layers were washed with brine, dried over anhydrous magnesium sulfate, filtered, concentratedand purified by flash column chromatography using pentane: EtOAc as solvents. The one pot ene-Prins reaction was performed by following the above procedure in which (-)-citronellal was usedinstead of isopulegol and 0.2 equivalents of BF3.Et2O to give (-)-3b, (-)-3a and (+)-5a. |
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