Chemistry Heterocyclic Building Blocks Indoles 1-methyl-1H-indole

1-methyl-1H-indole

These compounds have the same murcko framework: 1-methyl-1H-indole

Electrophilic Aromatic Substitution (EAS): Indoles are known for their reactivity in EAS reactions. The electron-rich nature of the aromatic ring makes them susceptible to electrophilic attack. The reaction typically occurs at the 2- or 3-position of the indole ring due to the presence of a nitrogen lone pair.
Nucleophilic Substitution: The nitrogen atom in the indole ring can act as a nucleophile, participating in nucleophilic substitution reactions with electrophiles.
Alkylation and Acylation: The nitrogen atom in the indole ring can be alkylated or acylated under appropriate conditions, leading to the formation of N-alkyl or N-acyl indole derivatives.
Friedel-Crafts Reactions: Indoles can undergo Friedel-Crafts acylation or alkylation reactions when treated with appropriate acylating or alkylating agents in the presence of a Lewis acid catalyst.
Reduction: The double bond in the 1-methyl-1H-indole could potentially undergo reduction, depending on the reaction conditions. This could yield a saturated derivative of the indole ring.
Oxidation: Indoles can be oxidized under certain conditions, leading to the formation of oxindoles or other oxidized products.
Mannich Reaction: The nitrogen in the indole ring can participate in the Mannich reaction, where it reacts with formaldehyde and a secondary amine to form a β-amino carbonyl compound.
Hofmann Rearrangement: Under specific conditions, the nitrogen in the indole ring can undergo Hofmann rearrangement, resulting in the migration of the nitrogen to a different position in the ring.

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(1-(tert-butoxycarbonyl)-1H-indol-2-yl)boronic acid (1H-indol-2-yl)boronic acid (1H-indol-2-yl)methanol (3aS,7aS)-octahydro-1H-indole (9H-fluoren-9-yl)methyl (2-(1H-indol-3-yl)ethyl)carbamate 1,2,3,4-tetrahydrocyclopenta[b]indole 1,2-dimethyl-1H-indole 1-(1H-indol-1-yl)ethan-1-one 1-(1H-indol-3-yl)ethan-1-one 1-(phenylsulfonyl)-1H-indole 1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine 1-benzyl-1H-indole 1-ethyl-1H-indole 1-methyl-1H-indole 1-methyl-1H-indole-2-carboxylic acid 1-methyl-1H-indole-3-carbaldehyde 1-methyl-1H-pyrrolo[2,3-b]pyridine 1-phenyl-1H-indole 1H-indol-3-ol 1H-indol-3-yl acetate 1H-indol-4-amine 1H-indol-4-ol 1H-indol-5-ol 1H-indol-6-amine 1H-indol-6-ol 1H-indol-7-amine 1H-indole-2-carbaldehyde 1H-indole-2-carbonitrile 1H-indole-3-carbonitrile 1H-indole-3-carboxylic acid 1H-indole-4-carboxylic acid 1H-indole-5-carbonitrile 1H-indole-5-carboxylic acid 1H-indole-6-carbonitrile 1H-indole-6-carboxylic acid 1H-indole-7-carbonitrile 1H-indole-7-carboxylic acid 1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole 2,3-dimethyl-1H-indole 2-(1,3,2-dioxaborolan-2-yl)-1-methyl-1H-indole 2-(1H-indol-1-yl)acetic acid 2-(1H-indol-3-yl)acetic acid 2-(1H-indol-3-yl)ethan-1-amine 2-(1H-indol-3-yl)ethan-1-ol 2-(2-methyl-1H-indol-3-yl)acetic acid 2-(4-fluorophenyl)-1H-indole 2-methyl-1H-indole-3-carbaldehyde 2-methyl-1H-pyrrolo[2,3-b]pyridine 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione 3-(1H-indol-3-yl)propanoic acid 3-(piperidin-4-yl)-1H-indole 3-iodo-1H-pyrrolo[2,3-b]pyridine 3-methyl-1H-indole 3H-indole 4-bromo-1H-indole 4-chloro-1H-indole 4-fluoro-1H-indole 4-fluoro-1H-pyrrolo[2,3-b]pyridine 4-fluoroindoline-2,3-dione 4-methoxy-1H-indole 4-methyl-1H-indole 4-nitro-1H-indole 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 5-(benzyloxy)-1H-indole 5-bromo-1-methyl-1H-indole 5-chloro-1H-indole 5-chloro-1H-indole-2-carboxylic acid 5-chloro-1H-pyrrolo[2,3-b]pyridine 5-fluoro-1H-indole 5-fluoro-1H-pyrrolo[2,3-b]pyridine 5-fluoroindolin-2-one 5-methoxy-1H-indole 5-methoxy-2-methyl-1H-indole 5-methyl-1H-indole 5-nitro-1H-indole 6-(trifluoromethyl)-1H-indole 6-bromo-1-methyl-1H-indole 6-bromo-1H-indole 6-bromo-1H-pyrrolo[2,3-b]pyridine 6-chloro-1H-indole 6-chloro-1H-pyrrolo[2,3-b]pyridine 6-fluoro-1H-indole 6-methoxy-1H-indole 6-methyl-1H-indole 6-methyl-1H-pyrrolo[2,3-b]pyridine 6-nitro-1H-indole 7-bromo-1H-indole 7-bromoindoline-2,3-dione 7-chloro-1H-indole 7-fluoro-1H-indole 7-fluoro-1H-indole-2-carboxylic acid 7-methoxy-1H-indole 7-methyl-1H-indole 7-nitro-1H-indole 9H-pyrido[3,4-b]indole benzo[cd]indol-2(1H)-one ethyl 1H-indole-3-carboxylate ethyl 5-chloro-1H-indole-2-carboxylate ethyl 5-fluoro-1H-indole-2-carboxylate ethyl 6-chloro-1H-indole-2-carboxylate ethyl 7-chloro-1H-indole-2-carboxylate methyl 1H-indole-3-carboxylate methyl 1H-indole-4-carboxylate methyl 1H-indole-5-carboxylate methyl 1H-indole-6-carboxylate methyl 1H-indole-7-carboxylate methyl 2-(1H-indol-3-yl)acetate N-(2-(1H-indol-3-yl)ethyl)acetamide spiro[indoline-3,4'-piperidin]-2-one tert-butyl 1H-indole-1-carboxylate tert-butyl 1H-pyrrolo[2,3-b]pyridine-1-carboxylate tert-butyl 2-(1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate tert-butyl 3-(hydroxymethyl)-1H-indole-1-carboxylate tert-butyl 3-bromo-1H-indole-1-carboxylate tert-butyl 3-iodo-1H-indole-1-carboxylate tert-butyl 5-methoxy-1H-indole-1-carboxylate tryptophan

By Key Group+−

aminoindole azaindole benzoindole benzyloxyindole biindolinylidene bromo-indole-carboxylate bromo-indole-carboxylic acid bromo-indole-carboxylic-acid bromo-methyl-indole bromoindole chlorindole-carboxylic-acid chloro-indole-carboxylate chloro-methyl indole chloroindole cyanoindole dihydroindolo dimethyl-indole dioxaborolan-indole dioxaborolan-indole-carboxylate fluorindole-carboxylic acid fluorindole-carboxylic-acid fluoro-indole-carboxylate fluoroindole fluoromethyl-indole formyl-indole-carboxylate formylindole hydroxyindole hydroxyisoindoline hydroxymethy-indole-carboxylate indol-amine indol-methanamine indol-methanol indol-one indole-boronic acid indole-boronic acid/ester indole-boronic-acid indole-carbonitrile indole-ethanol indole-ethylamine indole-hydrochloride indole-hydroxyl indolecarboxylate indolecarboxylic iodo-indole isoindole methoxy-indole-carboxylate methoxy-methyl-indole methoxyindole methyl-indole-carboxylic-acid methyl-nitro-indole methylindole nitro-indole-carboxylate nitroindole phenyl-indole piperidine-indole pyridinoindole pyrimido-indole trifluoromethyl-indole

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    By Configuration+−

    2,2,2-Trifluoro-1-(1-methyl-1H-indol-3-yl)ethan-1-ol

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    A248488116757-91-695+%

    2,2,2-Trifluoro-1-(1-methyl-1H-indol-3-yl)ethan-1-ol

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    1-Methylindole-7-boronic acid

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    1-Methylindole-7-boronic acid

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    1-Methyl-1H-indol-2-ol

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    1-Methyl-1H-indol-2-ol

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    (1-Methyl-1H-indol-2-yl)methanamine

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    (1-Methyl-1H-indol-2-yl)methanamine

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    N-Methyl-1-(1-methyl-1H-indol-2-yl)methanamine

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    N-Methyl-1-(1-methyl-1H-indol-2-yl)methanamine

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    Potassium trifluoro(1-methylindol-2-yl)borate

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    Potassium trifluoro(1-methylindol-2-yl)borate

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    1-Methyl-1H-indole-4-carbaldehyde

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    A214069133994-99-795%

    1-Methyl-1H-indole-4-carbaldehyde

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    (1-Methyl-1H-indol-4-yl)boronic acid

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    (1-Methyl-1H-indol-4-yl)boronic acid

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    1-Methyl-1H-indole-7-carbaldehyde

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    A36583069047-36-597%

    1-Methyl-1H-indole-7-carbaldehyde

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    1-Methylindole

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    A276445603-76-998%

    1-Methylindole

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    5-Amino-1-N-methylindole

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    5-Amino-1-N-methylindole

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    1-Methyl-1H-indole-5-carboxaldehyde

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    1-Methyl-1H-indole-5-carboxaldehyde

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    (1-Methyl-1H-indol-5-yl)methanamine

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    (1-Methyl-1H-indol-5-yl)methanamine

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    1-Methylindole-5-boronic acid

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    1-Methylindole-5-boronic acid

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    1-Methyl-5-(trifluoromethyl)-1H-indole

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    A1181351264670-41-897%

    1-Methyl-5-(trifluoromethyl)-1H-indole

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    1-Methyl-1H-indole-6-carbaldehyde

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    1-Methyl-1H-indole-6-carbaldehyde

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    (1-Methyl-1H-indol-6-yl)methanol

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    (1-Methyl-1H-indol-6-yl)methanol

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    Ethyl 1-methyl-1H-indole-6-carboxylate

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    Ethyl 1-methyl-1H-indole-6-carboxylate

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    1-Methyl-1H-indole-4-sulfonyl chloride

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    1-Methyl-1H-indole-4-sulfonyl chloride

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    1-Methyl-3-nitro-1H-indole

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    1-Methyl-3-nitro-1H-indole

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    (1-Methyl-1H-indol-2-yl)boronic acid

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    (1-Methyl-1H-indol-2-yl)boronic acid

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    6-Amino-1-methylindole

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    6-Amino-1-methylindole

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    1-Methyl-1H-indole-7-carboxylic acid

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    A864816167479-16-598%

    1-Methyl-1H-indole-7-carboxylic acid

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    6-Methoxy-1-methyl-1H-indole-3-carbaldehyde

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    A252103202807-44-198%

    6-Methoxy-1-methyl-1H-indole-3-carbaldehyde

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    1-Methyl-1H-indole-5-carbonitrile

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    1-Methyl-1H-indole-5-carbonitrile

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    5-Bromo-1,3-dimethyl-1H-indole

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    A16740010075-49-797%

    5-Bromo-1,3-dimethyl-1H-indole

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    1,2-Dimethyl-1H-indol-5-amine

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    1,2-Dimethyl-1H-indol-5-amine

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    1,5-Dimethyl-1H-indole-2-carbaldehyde

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    A138667883526-76-995%

    1,5-Dimethyl-1H-indole-2-carbaldehyde

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