Chemistry Heterocyclic Building Blocks Tetrazoles
Tetrazoles are a type of synthetic organic heterocyclic compound that comprises a 5-member ring containing four nitrogen atoms and one carbon atom.
Because tetrazoles are deprotonated at physiological pH and have a similar pKa value, they can serve as bioisosteres for carboxylate groups.
Losartan and candesartan are types of Angiotensin II receptor blockers, which are commonly classified as tetrazoles. An example of a well-known tetrazole is MTT (dimethyl thiazolyl diphenyl tetrazolium bromide).
The tetrazole ring is a common feature among pharmaceutical drugs with antihypertensive effects, as well as those with antibiotic and anti-allergic properties.
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Ethyl 2-methyl-2H-tetrazole-5-carboxylate
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(1H-Tetrazol-5-yl)methanamine hydrochloride