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CAS No. : | 932744-62-2 | MDL No. : | |
Formula : | C56H65ClN12O10 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 1101.64 | Pubchem ID : | - |
Synonyms : |
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Chemical Name : | (S)-1-(Chloromethyl)-3-(5-(4-((S)-2-((S)-2-((2-(4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanamido)ethyl)amino)-3-methylbutanamido)-5-ureidopentanamido)benzamido)-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-5-yl 4-methylpiperazine-1-carboxylate |
Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
51% | With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20℃; for 2h; | Compound 29: To a solution of 27 (31 mg, 0.033 mmol) in 20% DMF in dichloromethane (1 mL) were added diisopropylethylamine (22 muL, 0.13 mmol) and N-succinimidyl-4-maleimidobutyrate (14 mg, 0.049 mmol) at room temperature. The mixture thus obtained was stirred for 2 hours. The solvent was evaporated and the residue was purified by semi-preparative HPLC to give compound 29 as a white solid (32 mg, 51%). 1H NMR (CD3OD) delta 1.09 (d, 3H), 1.15 (d, 3H), 1.62 (m, 2H), 1.84 (m, 1H), 1.92 (m, 3H), 2.25 (m, 3H), 2.97 (s, 3H), 3.12-3.25 (m, 6H), 3.39-3.68 (m, 10H), 3.85 (d, 1H), 3.93 (dd, 1H), 4.08 (m, 1H), 4.50-4.67 (m, 4H), 6.80 (s, 2H), 7.03 (s, 1H), 7.34 (m, 2H), 7.44 (m, 1H), 7.50 (m, 1H), 7.72 (d, 2H), 7.77 (d, 1H), 7.90 (m, 3H), 8.04 (s, 1H), 8.25 (bs, 1H); LC-MS (ES+) 552 (M+2H/2)+. |