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Stage #1: 4-fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]isoquinoline hydrochloride With water at 80℃;
Stage #2: In water; acetone at 20℃;
80%
Stage #1: 4-fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]isoquinoline hydrochloride With water at 80℃;
Stage #2: In water; isopropyl alcohol at 20℃;
Stage #1: 4-fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]isoquinoline hydrochloride With water at 80℃;
Stage #2: In ethanol; water at 20℃;