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[ CAS No. 88235-25-0 ] {[proInfo.proName]}

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
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Chemical Structure| 88235-25-0
Chemical Structure| 88235-25-0
Structure of 88235-25-0 * Storage: {[proInfo.prStorage]}
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Product Details of [ 88235-25-0 ]

CAS No. :88235-25-0 MDL No. :MFCD00057884
Formula : C12H14N4O5 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 294.26 Pubchem ID :-
Synonyms :
C-6 NBD;​6-(7-Nitrobenzofurazan-4-ylamino)hexanoic Acid;NBD-X;NBD Hexanoic Acid

Safety of [ 88235-25-0 ]

Signal Word:Danger Class:6.1
Precautionary Statements:P261-P280-P305+P351+P338-P311 UN#:2811
Hazard Statements:H301+H311+H331-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 88235-25-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 88235-25-0 ]

[ 88235-25-0 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 10199-89-0 ]
  • [ 60-32-2 ]
  • [ 88235-25-0 ]
YieldReaction ConditionsOperation in experiment
100% With sodium hydrogencarbonate In methanol at 0 - 50℃; for 3.5h; full text could not be excerpted from SI
91% With sodium hydrogencarbonate In water; acetonitrile at 65℃; for 2h;
87% With sodium hydrogencarbonate In methanol at 0 - 50℃; for 3.5h; Inert atmosphere;
77% With sodium hydrogencarbonate
63% With sodium hydrogencarbonate In methanol at 0 - 50℃; for 3.5h;
61% With sodium hydrogencarbonate In methanol; water at 0 - 50℃; for 3h;
57% With N-ethyl-N,N-diisopropylamine In methanol at 20℃;
55% With sodium hydrogencarbonate In methanol at 50℃; for 3h;
35% With sodium hydrogencarbonate In methanol; water at 20℃; for 24h;
With sodium hydrogencarbonate In water; acetonitrile at 55℃;
With sodium hydrogencarbonate In water at 20 - 50℃; for 13.5h; Cooling with ice; The synthesis method of compound II is as follows (taking R=(CH2)5 as an example): One equivalent of 6-aminocaproic acid, 3 equivalents of NaHCO 3 dissolved in water, and one equivalent of NBD-Cl are added dropwise on an ice bath.After stirring for 1.5 hours at room temperature, the reaction was carried out at 50°C for 12 hours.After the reaction is complete, the solid precipitates out of aqueous HCl solution.After filtration and drying, compound II was obtained.

Reference: [1]Greco, Graziella; D'Antona, Nicola; Gambera, Giovanni; Nicolosi, Giovanni [Synlett, 2014, vol. 25, # 15, p. 2111 - 2114]
[2]Woodland, John G.; Hunter, Roger; Smith, Peter J.; Egan, Timothy J. [Organic and Biomolecular Chemistry, 2017, vol. 15, # 3, p. 589 - 597]
[3]Storz, Michael P.; Allegretta, Giuseppe; Kirsch, Benjamin; Empting, Martin; Hartmann, Rolf W. [Organic and Biomolecular Chemistry, 2014, vol. 12, # 32, p. 6094 - 6104]
[4]Jida, Mouhamad; Sanchez, Cecilia P.; Urgin, Karène; Ehrhardt, Katharina; Mounien, Saravanan; Geyer, Aurelia; Elhabiri, Mourad; Lanzer, Michael; Davioud-Charvet, Elisabeth [ACS Infectious Diseases, 2017, vol. 3, # 2, p. 119 - 131]
[5]Novotný, Jakub; Pospěchová, Kateřina; Hrabálek, Alexandr; Čáp, Robert; Vávrová, Kateřina [Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 24, p. 6975 - 6977]
[6]Huang, Chusen; Yin, Qin; Meng, Jiangjiang; Zhu, Weiping; Yang, Yi; Qian, Xuhong; Xu, Yufang [Chemistry - A European Journal, 2013, vol. 19, # 24, p. 7739 - 7747]
[7]Ludolph, Bjoern; Waldmann, Herbert [Chemistry - A European Journal, 2003, vol. 9, # 15, p. 3683 - 3691]
[8]Wenskowsky, Lea; Schreuder, Herman; Derdau, Volker; Matter, Hans; Volkmar, Julia; Nazaré, Marc; Opatz, Till; Petry, Stefan [Angewandte Chemie - International Edition, 2018, vol. 57, # 4, p. 1044 - 1048][Angew. Chem., 2018, vol. 130, p. 1056 - 1060,5]
[9]Kopečná, Monika; Kováčik, Andrej; Kučera, Ondřej; Macháček, Miloslav; Sochorová, Michaela; Audrlická, Pavla; Vávrová, Kateřina [Molecular Pharmaceutics, 2019, vol. 16, # 2, p. 886 - 897]
[10]Haldar, Saikat; Kumar, Santosh; Kolet, Swati P.; Patil, Harshal S.; Kumar, Dhiraj; Kundu, Gopal C.; Thulasiram, Hirekodathakallu V. [Journal of Organic Chemistry, 2013, vol. 78, # 20, p. 10192 - 10202]
[11]Current Patent Assignee: ZHEJIANG UNIVERSITY - CN105295896, 2017, B Location in patent: Paragraph 0053; 0054
  • 2
  • [ 73724-43-3 ]
  • [ 111061-56-4 ]
  • [ 88235-25-0 ]
  • [ 438620-68-9 ]
  • NBDAca-Ser(Trt)-Cys(SS-t-Bu)-Lys(Aloc)-Cys(farnesyl) [ No CAS ]
  • 3
  • [ 1196-92-5 ]
  • [ 88235-25-0 ]
  • C20H23N5O6 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 24h; 1 Example 1: Take 1 equivalent of compound I and 1 equivalent of R=(CH2)5 compound II,Soluble in DMF,Add 1 equivalent of HOBT,1 equivalent DCC, 0.1 equivalent DMAP,Stir at room temperature for 24 hours. Remove organic solvents,Column chromatography,Elution with dichloromethane:methanol = 10:1,The corresponding compound III is obtained.
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