There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 88235-25-0 | MDL No. : | MFCD00057884 |
Formula : | C12H14N4O5 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 294.26 | Pubchem ID : | - |
Synonyms : |
C-6 NBD;6-(7-Nitrobenzofurazan-4-ylamino)hexanoic Acid;NBD-X;NBD Hexanoic Acid
|
Signal Word: | Danger | Class: | 6.1 |
Precautionary Statements: | P261-P280-P305+P351+P338-P311 | UN#: | 2811 |
Hazard Statements: | H301+H311+H331-H315-H319-H335 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With sodium hydrogencarbonate In methanol at 0 - 50℃; for 3.5h; | full text could not be excerpted from SI |
91% | With sodium hydrogencarbonate In water; acetonitrile at 65℃; for 2h; | |
87% | With sodium hydrogencarbonate In methanol at 0 - 50℃; for 3.5h; Inert atmosphere; |
77% | With sodium hydrogencarbonate | |
63% | With sodium hydrogencarbonate In methanol at 0 - 50℃; for 3.5h; | |
61% | With sodium hydrogencarbonate In methanol; water at 0 - 50℃; for 3h; | |
57% | With N-ethyl-N,N-diisopropylamine In methanol at 20℃; | |
55% | With sodium hydrogencarbonate In methanol at 50℃; for 3h; | |
35% | With sodium hydrogencarbonate In methanol; water at 20℃; for 24h; | |
With sodium hydrogencarbonate In water; acetonitrile at 55℃; | ||
With sodium hydrogencarbonate In water at 20 - 50℃; for 13.5h; Cooling with ice; | The synthesis method of compound II is as follows (taking R=(CH2)5 as an example): One equivalent of 6-aminocaproic acid, 3 equivalents of NaHCO 3 dissolved in water, and one equivalent of NBD-Cl are added dropwise on an ice bath.After stirring for 1.5 hours at room temperature, the reaction was carried out at 50°C for 12 hours.After the reaction is complete, the solid precipitates out of aqueous HCl solution.After filtration and drying, compound II was obtained. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 24h; | 1 Example 1: Take 1 equivalent of compound I and 1 equivalent of R=(CH2)5 compound II,Soluble in DMF,Add 1 equivalent of HOBT,1 equivalent DCC, 0.1 equivalent DMAP,Stir at room temperature for 24 hours. Remove organic solvents,Column chromatography,Elution with dichloromethane:methanol = 10:1,The corresponding compound III is obtained. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / methanol / 12.33 h / 20 - 25 °C 2: trifluoroacetic acid / dichloromethane / 2 h / 0 - 25 °C / Inert atmosphere |