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(S)-2,2,2-trifluoro-1-(methyl)ethylamine hydrochloride[ No CAS ]
[ 98-88-4 ]
[ 881426-13-7 ]
Yield
Reaction Conditions
Operation in experiment
With pyridine
6
The total yield of the first purified crystals, the second purified crystals, and the third crude crystals was 90%. Enantiomer excess (e. e.) was determined by chiral gas chromatography, after the salt of optically active 1-alkyl-substituted 2,2,2-trifluoroethylamine was converted into a benzamide derivative using excessive benzoyl chloride and pyridine. 1H-NMR spectrum and 19F-NMR spectrum are shown in the following. 1H-NMR (standard substance: TMS, solvent: DMSO-d6), δ ppm: 1.37(d,7.2Hz,3H), 4.24(septet,7.2Hz,1H), 9.24(br,3H). 19F-NMR(standard substance:C6F6, solvent:DMSO-d6), δ ppm: 88.03(d,7.2Hz,3F).